Dr. Kozloff is an Associate Professor of Orthopaedic Surgery at the University of Michigan. Dr. Kozloff performed his undergraduate studies in Materials Science and Engineering at the University of Michigan, followed by doctoral training in Biomedical Engineering. After receiving his PhD from the University of Michigan, Dr. Kozloff completed a post-doctoral fellowship at the Center for Molecular Imaging Research at Massachusetts General Hospital and Harvard Medical School in Boston, followed by additional post-doctoral training in the Bone Cell Biology Laboratory of the Department of Orthopaedic Surgery at Boston Children’s Hospital. In 2007, Dr. Kozloff returned to Ann Arbor and joined the faculty of the Department of Orthopaedic Surgery as part of the Orthopaedic Research Laboratories. Dr. Kozloff’s research focuses on the regulation and measurement of bone mass and quality as it relates to diseases of genetic, hormonal, or mechanical origin. The role of traditional and novel bone therapeutics in the modulation of bone quality is of particular interest due to the emergence of potential complications attributed to skeletal-drug interactions. Pediatric diseases such as osteogenesis imperfecta pose unique challenges given the complex interplay between skeletal growth and bone fragility. The use of molecular imaging techniques are combined with engineering methods to provide visualization of bone cell function and skeletal drug delivery in the context of local mechanical cues. Ultimately, these studies will help develop strategies to reduce fracture risk and improve response to injury across a wide variety of patient populations. Dr. Kozloff has been recognized with young investigator awards from the Society for Molecular Imaging, the Orthopaedic Research Society, and the American Society for Bone and Mineral Research. His trainees have also received honors from the Sun Valley Workshop on Skeletal Tissue Biology, the International Society of Biomechanics, the American Society for Bone and Mineral Research, the Endocrine Fellows Foundation, and the European Connective Tissue Society. Dr. Kozloff holds an additional appointment in the Department of Biomedical Engineering and lectures to students and residents on topics related to biomechanics and skeletal physiology.
Areas of Interest
Non-invasive imaging of bone metabolism. Effects of anti-resorptive agents on bone. Cellular response of bone to damage. Collagen influence on mechanical and structural properties of bone. Role of bone microenvironment in predilection of cancer metastases to bone. Dr. Kozloff's Lab: www.umich.edu/~skeleton
Education and Credentialing
Degree Ph.D., 2005, University of Michigan Fellowships Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School. 2005-2007 Department of Orthopaedic Surgery, Children’s Hospital Boston, Harvard Medical School. 2007