The primary purpose of sequencing genomes is to identify the underlying genetic variation between individuals and to explore what role those changes have on human phenotypes. My research laboratory develops and implements methods to precisely identify and resolve diverse types of genomic variation. Our goal is to integrate this information with other forms of biologically and medically relevant data to improve our overall understanding of human health and disease. My current research is focused on developing methods to resolve variation in complex and repetitive regions of the genome both independently and also through participation in the Human Genome Structural Variation Consortium. We recently joined the Integrating Genome Variation with Function Consortium to explore the functional impact of these and other variants. I have also studied the impact of somatic structural genomic variation in neuropsychiatric diseases as part of the Brain Somatic Mosaicism Network, where we analyzed low frequency mosaic variation in human brain tissue with state-of-the-art technologies, and I am now a funded member of the Somatic Mosaicism across Human Tissues (SMaHT) Consortium. In summary, I have a demonstrated record of accomplished and productive research projects in an area of relevance to high throughput genomic analysis and have contributed to many of the common genomic reference sets in use by the biomedical community today.