Molecular mediators of stress and anxiety; regulation and role of CRH, the CRH receptors and CRH-binding protein in stress; mechanisms of transcriptional regulation; transgenic mice.
Our lab studies mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development.
The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer.
MORE Mentor Training, Implicit Bias Training, Change It Up!, Intercultural Training, Bystander Training, Gender Bias or Discrimination Training
Research Interests:
Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.
MORE Mentor Training, Implicit Bias Training, Anti-Racism Training, Gender Bias or Discrimination Training, member, DEI recruitment and retention committee, Neurology
Research Interests:
Nucleotide Repeat expansions; protein translation; neurodegeneration; RNA biology; ALS/FTD; Ataxia.
Our laboratory is interested in elucidating the molecular mechanisms underlying chromatin modifications that regulate gene expression and other chromatin-associated functions.
The aims of our research are to understand the core mechanisms that drive brain cancers such as diffuse intrinsic pontine gliomas( DIPG) and ependymomas in children, as well as gliomas in adults.
We seek to understand essential cellular processes — using cultured neurons, cell lines and yeast — in order to shed new light on neurodegeneration, cancer and other diseases.
Normal as well as neoplastic cell populations remodel the extracellular matrix by regulating the expression of complex gene programs that control cell motility, proteolytic activity, proliferation.
The mechanisms by which multi-nucleated osteoclasts stimulate osteoblastic bone formation in order to identify therapeutic targets to promote bone formation in aging and cancer-induced bone disease.