February 29, 2024

CPOD Faculty Publication Spotlight - Squarize Lab

Yujra VQ, Dantas da Silveira EJ, Ribeiro DA, Castilho RM, Squarize CH. Journal of Cellular Biochemistry. 2024 Feb;125(2):e30513. Clock gene Per2 modulates epidermal tissue repair in vivo.
"The circadian clock is an internal time-keeping system conserved across species. We found that knockout mice for the circadian gene PER2 exhibit substantially accelerated wound healing through rapid re-epithelialization, attributing to the increased proliferation of skin cells and angiogenesis happening both in and around the wound site. The study also found enhanced maturation of collagen fibers and tissue remodeling. The collective findings from this research highlight the integral role of the PER2 gene in the skin's healing process and hint at exciting new therapeutic possibilities that harness circadian gene modulation to improve tissue regeneration."
Pictured left to right: Dr. Veronica Q. Yujra, D.D.S., M.S. (PhD Student, Periodontics and Oral Medicine, University of Michigan) and Dr. Cristiane H. Squarize, D.D.S, M.S. Ph.D. (Professor, Periodontics and Oral Medicine, University of Michigan)