March 21, 2024

CPOD Faculty Publication Spotlight - Jenkins Lab

Nelson AD, Catalfio AM, Gupta JP, Min L, Caballero-Florán RN, Dean KP, Elvira CC, Derderian KD, Kyoung H, Sahagun A, Sanders SJ, Bender KJ, Jenkins PM. Neuron. 29 January 2024. Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites. 
"In this manuscript, we show that ankyrin-B (Ank2) is essential for scaffolding NaV1.2 (Scn2a) to the dendritic membrane of mouse neocortical neurons, and that haploinsufficiency of Ank2 phenocopies intrinsic dendritic excitability and synaptic deficits observed in Scn2a+/-conditions. These results establish a direct, convergent link between two major autism spectrum disorder risk genes and reinforce an emerging framework suggesting that neocortical pyramidal cell dendritic dysfunction can contribute to neurodevelopmental disorder pathophysiology."


Pictured: Dr. Paul Jenkins, Ph.D. (Assistant Professor, Pharmacology and Psychiatry, University of Michigan) with members of his lab.