I graduated from The Ohio State University in 2021 with a B.S. in Molecular Genetics. During my time at Ohio State, I investigated the role of commensal gut microbiome disruption in mediating stress-induced immune and neurodevelopmental changes during pregnancy. In the Pasca di Magliano lab, I use my previous experiences in immunology and genetics to inform my research into developmental pathways that program the tumor-immune microenvironment in pancreatic cancer.
I study the role of evolutionarily conserved developmental pathways in dictating fibroblast phenotypes in the pancreatic tumor microenvironment. Beyond their role in embryonic development, pathways such as Notch and Wnt signaling play critical roles in regulating cell fate throughout our lifespan. By modulating these pathways in vivo, I hope to elucidate ways to reprogram cancer-associated fibroblasts to adopt tumor-restricting phenotypes in the context of pancreatic ductal adenocarcinoma.
Single-cell RNA-sequencing, mouse modeling, immunofluorescence, cell culture
2023-Present DK094775, Training in Basic and Translational Digestive Sciences T32
2023 Rackham Candidate Research Grant
2022-2023 Rogel Cancer Center Scholarship Fund, University of Michigan
2022 Rackham Pre-Candidate Research Grant
2021 Benard L. Maas Fellowship, University of Michigan
2021 BS, Summa Cum Laude, The Ohio State University
2021 Honors Diploma with Research Distinction, The Ohio State University
Bischoff A. Zhang Y., Yan W., Brown K., Du, W. Pasca di Magliano M. WT1+ cancer-associated fibroblasts promote pancreatic cancer growth, CSHL Biology of Cancer: Microenvironment & Metastasis, September 2023
Bischoff A. Zhang Y., Yan W., Brown K., Du, W. Pasca di Magliano M. WT1+ cancer-associated fibroblasts promote pancreatic cancer growth, AACR Special Conference: Pancreatic Cancer, September 2022