Matthias Kretzler, MD

Matthias Kretzler, MD

Warner-Lambert/Parke-Davis Professor, Internal Medicine-Nephrology
Professor, Computational Medicine & Bioinformatics
Internal Medicine-Nephrology
1570A Medical Science Research Building II
Ann Arbor, Michigan 48109
Diabetic Kidney Disease

Integrating and interpreting large-scale data to develop treatments for kidney diseases

The overarching goal of Dr. Kretzler's research is to define chronic kidney disease in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal he and his team have developed a translational research pipeline centered on integrated systems biology analysis of renal disease.

Dr. Kretzler has 25 years of experience on interdisciplinary data integration of large-scale data sets in international multi-disciplinary research networks in the United States, Europe, China, and sub-Saharan Africa. These studies enable precision medicine across the genotype-phenotype continuum using carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological biopsy archive and prospective clinical disease characterization. The molecular mechanisms identified have resulted in new disease predictors, new drug development and successful clinical trials of novel therapeutic modalities in chronic kidney disease.


  • Undergraduate, University of Heidelberg, Newcastle upon Tyne (U.K.)
  • MD, University of Michigan and Michigan (USA), 1992
  • MD/PhD, Graduiertenkolleg Niere, University of Heidelberg, 1993
  • Research Fellowship, Department of Physiology and Nephrology, University of Michigan, 1994
  • Intern/Resident, Internal Medicine, Medical Policlinic, University of Munich, 1999
  • Fellowship, Nephrology Center, University of Munich, 2002

Honors & Awards

  • German academic exchange Scholarship, University of Newcastle, 1990
  • German research foundation post-doctoral fellowship, 1993
  • Nephrology Forum Award, 1995
  • University of Hannover, Jan Brod Award, 1998
  • German Nephrology Association, Janssen-Cilag-Award, 1999
  • German Nephrology Association, Carl Ludwig Young Investigator Award, 2001
  • University of Michigan, Clinical Science Scholar Award, 2005
  • Honorary member of the Australian-New Zealand Society of Nephrology, 2006
  • Alliance for Lupus Research, Leadership Circle Investigator, 2007
  • Juvenile Diabetes Research Foundation, Mary Jane Kugel Award, 2009
  • American Society of Nephrology, Young Investigator Award, 2009
  • Election in the American Society of Clinical Investigation, 2011
  • Distinguished Fellow of the European Renal Association, 2014
  • Washington University, Research Exemplar Award, 2017
  • Inducted as Member of American Academy of Physicians, 2018
  • Michigan Institute for Clinical & Health Research Distinguished Clinical and Translational Research Mentor Award, 2019