Sarah Elzinga, PhD, photo

Sarah Elzinga, PhD

Edith Briskin Emerging Scholar
Postdoctoral Fellow
Department of Neurology
5017 BSRB
Ann Arbor MI 48109-2200

Diabetes and obesity injure the brain and peripheral nerves

Dr. Sarah Elzinga’s goal is to understand how immune system pathways respond to damage at the cellular level to promote inflammation and injure the nervous system, and she is utilizing multiple models to examine nervous system injury and cognitive decline. One model includes a novel 3D culture system, developed in collaboration with the University of Michigan’s bioengineering department, that is increasing our understanding of how the different cell types in the nervous system interact. Additionally, work in other model systems has begun to uncover the underlying mechanisms and present possible treatment options for brain and nerve injury secondary to diabetes and obesity.

Credentials

  • BS, Equine Science, Saint Mary-of-the-Woods College, 2005
  • MS, Animal Science, Michigan State University, 2011
  • PhD, Veterinary Science/Immunology & Endocrinology, University of Kentucky, 2017

Honors & Awards

  • Michigan Alzheimer’s Disease Research Center’s Early Career Investigator Mentorship Program
  • T32 trainee, University of Michigan National Institutes of Health Multidisciplinary Postdoctoral Training Program in Basic Diabetes Research and Endocrinology Fellowship Training Program
  • Biointerface Institute Challenge Grant
  • Young Investigator Award, American Quarter Horse Association Foundation
  • External review committee member, Gluck Center for Equine Research

Top Publications

Kim B., Elzinga S.*, et al. “The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in vitro and in vivo models of Alzheimer's disease” Neurobiology of disease 132 (2019):104541.
*co-first authorship

Elzinga, Sarah E.*, et al. "Sex differences in insulin resistance but not peripheral neuropathy in a diet-induced prediabetes mouse model." Disease models & mechanisms 14.4 (2021).
*co-first authorship 

Elzinga, Sarah E.*, et al. "Sex differences in insulin resistance but not peripheral neuropathy in a diet-induced prediabetes mouse model." Disease models & mechanisms 14.4 (2021).
*co-first authorship 

Guo K., Eid S.A., Elzinga S.,* Pacut C., Feldman E.L., Hur J. “Genome-Wide Profiling of DNA Methylation and Gene Expression Identifies Candidate Genes for Human Diabetic Neuropathy.” Clinical Epigenetics 12 no. 1 (2020):1-16. 
*co-first authorship.

Guo K., Elzinga S.,* Eid S., et al. “Genome-wide DNA methylation profiling of human diabetic peripheral neuropathy in subjects with type 2 diabetes mellitus” Epigenetics 14.8 (2019):766-779. 
*co-first authorship