Discovering genetic and environmental risk factors for amyotrophic lateral sclerosis
Dr. Stephen Goutman’s clinical and research expertise is focused on Amyotrophic lateral sclerosis (ALS), a progressive, fatal neurodegenerative disease with limited treatment options. Dr. Goutman is the Director of the University of Michigan Pranger ALS Clinic, an ALS Association Certified Center of Excellence, where a team of providers deliver comprehensive and compassionate care to persons with ALS and their families.
Inspired by his patients, Dr. Goutman’s research focuses on identifying new mechanisms and therapies for ALS. His research expertise is focused on understanding the genetic and environmental interactions that alter susceptibility to ALS, especially in the State of Michigan which has some of the highest rate of ALS in the country. With funding from the National Institutes of Health, the Centers for Disease Control and Prevention, and the ALS Association, he is discovering environmental risk factors associated with the onset and progression of ALS by collecting epidemiologic exposure surveys and biofluids from individuals with and without ALS. His research shows a link between ALS and pesticides, and his recent article on this work received widespread attention, as this important finding may help solve the mystery of ALS. Dr. Goutman also collaborates with teams of scientists to identify the immune system’s role in ALS and find new drugs that can address these changes in the immune system.
Dr. Goutman serves as site principal investigator of several multi-site clinical trials focused on identifying new ALS treatments. He is an active participant with the Northeast ALS Consortium (NEALS) and has close to a decade of experience leading ALS clinical trials at University of Michigan.
- BS, Neuroscience, Johns Hopkins University, 2002
- MD, University of Chicago Pritzker School of Medicine, 2007
- Neurology Residency & Neuromuscular Fellowship, Cleveland Clinic, 2011-12
- MS, Clinical Research Design and Statistical Analysis, University of Michigan, 2015
Honors & Awards
- Young Investigator Award, World Federation of Neurology Research Group on Motor Neuron Diseases
A multidisciplinary group of University of Michigan researchers will investigate environmental exposures, chosen as one of the first projects in a new National Institutes of Health amyotrophic lateral sclerosis initiative.
Deanna Lites speaks to Dr. Goutman about why it's important to look at environmental factors in ALS, which will be part of the new ALS medical moonshot thanks to a $3.6 million grant from the NIH.
A CDC-funded multidisciplinary effort at U-M will investigate air pollution as a major and modifiable risk factor for ALS and seek to identify therapy targets.
The National ALS Registry, managed by the Center for Disease Control (CDC) is one of the most important weapons in the fight against Amyotrophic Lateral Sclerosis (ALS). At the Annual Surveillance Meeting, Pranger ALS Clinic Director Dr. Stephen Goutman presented an update of important findings funded by the CDC.
This marks the first time that Drs. Stephen Goutman and Benjamin Murdock have been awarded an R01 grant by the NIH.