Subramanium Pennathur, MD

Subramaniam Pennathur, MD

Chief and Norman Radin Professor, Internal Medicine-Nephrology
Associate Professor, Molecular and Integrative Physiology
Director, Molecular Phenotyping and Metabolomics Core
Brehm Center
1000 Wall Street
Ann Arbor, Michigan 48105

Understanding molecular mechanisms involved in diabetic complications

Dr. Pennathur's interest is to define the role of oxidative stress on disease pathogenesis and complications, including diabetic complications, chronic kidney disease, autoimmune disease and cardiovascular disease. He has utilized mass spectrometry to identify key protein and metabolite alterations in disease states and tested the hypothesis whether these alterations predict complications in animal models and humans. The strategy has been to develop analytical techniques in animal models and validate these markers in humans and then investigating the animal model for biological pathway relevance. Recent extensions of this work have included targeted as well as untargetted metabolomic and proteomic profiling.


  • MD, Tirunelveli Medical College, 1991 
  • Residency, Barnes West County Hospital, Internal Medicine, 1996

  • Fellowship, Internal Medicine Nephrology, Washington University School of Medicine, 2001

  • Fellowship, Endocrinology, Washington University School of Medicine, 1999



Honors & Awards

  • National Institutes of Health Medical Resident Research Award, 1994
  • Oxygen Society, Young Investigator Award, 1997
  • Endocrine Society Research Award, 1998
  • Oxygen Society, Young Investigator Award, 1999
  • Merck Atherosclerosis Young Investigator Award, 2000
  • National Institutes of Health, Physician Scientist Award, 2003
  • Doris Duke Foundation, Clinical Scientist Development Award, 2007
  • Jerome W. Conn Award for Research Excellence, 2012
  • House Officer Research Mentoring and Teaching Award, 2017