Chad M. Brummett, M.D.

Bert N. LaDu Professor of Anesthesiology
Senior Associate Chair for Research
Professor, Anesthesiology
Co-Director, Michigan Opioid Prescribing Engagement Network


Dr. Brummett is the Director of the Division of Pain Research and, more broadly, is the Director of Clinical Research in the Department of Anesthesiology. His interests include predictors of chronic post-surgical pain as well as failure to derive benefit from interventions and surgeries done primarily for pain. In particular, Dr. Brummett is interested in the impact of a fibromyalgia-like or centralized pain phenotype on surgical outcomes and prediction of response to interventions for chronic pain (e.g. Epidural steroid and facet injections). He also leads an institution-wide initiative to create a biorepository for research of genetic factors associated with the development of disease and response to treatment. In addition, Dr. Brummett was the first to describe the use of peripheral perineural dexmedetomidine, and his early research focused on the efficacy, safety and mechanisms of dexmedetomidine added to local anesthetics for peripheral nerve blocks. He has since translated that work to humans. Please see his recent publications.

Areas of Interest

  • Phenotypic and genotypic predictors of acute and chronic post-surgical pain: Clinical research following surgical patients longitudinally to determine genotypic and phenotypic predictors of acute pain sensitivity and chronic post-surgical pain. Research particularly focused on the role of central pain processing and centralized pain on acute and chronic pain outcomes. Future goals are to develop point-of-care testing for any genetic predictors and patient-report outcomes measures found in the first phases to allow for studies of acute analgesic interventions to attenuate acute pain and potentially prevent chronic post-surgical pain.Impact of central pain on responsiveness to minimally-invasive pain interventions: Clinical research designed to assess phenotypic measures of central pain and assess the impact of centralized pain on the response to the various injections and minimally-invasive interventions commonly performed in pain medicine, in particular facet interventions. Long-term goals are to create better predictive models of success and failure to personalize analgesic regimens. 
  • Additives to local anesthetics to enhance the duration of postoperative analgesia after peripheral nerve blockade: Laboratory and clinical research focused on the development of drug combinations to enhance the duration of analgesia and improve safety following peripheral nerve blocks. Work primarily focused on the use of dexmedetomidine as an additive to local anesthetics.
  • Peripheral nerve injury: Studies focus on risk factors and predictors of perioperative peripheral nerve injury as a means to better identify patients at risk and implement preventative measures.

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