Obesity, prediabetes and diabetes underlie nerve damage
Dr. Callaghan’s research is focused on the metabolic factors that are associated with neuropathy. He has completed four observational studies that have demonstrated that hyperglycemia, obesity, and the number of metabolic syndrome components (increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol levels), but not hypertension or dyslipidemia, are associated with neuropathy. This has led to a proposed interventional study of surgical weight loss and/or high intensity interval training to determine if either intervention can prevent nerve injury. If successful, either intervention would be the first disease modifying therapy for neuropathy. In February 2018, he published “Diabetes and Obesity Are the Main Metabolic of Peripheral Neuropathy,” in the Annals of Clinical and Translational Neurology.
Dr. Callaghan has investigated ways to improve the efficiencies of healthcare delivery within neurology with a focus on peripheral neuropathy. Additionally, he has studied the utilization and costs associated with neurologic testing, prescriptions, and neurologic visits with implications for payment reform.
- BS, Cellular and Molecular Biology, University of Michigan, 2004
- MD & Neurology Residency, University of Pennsylvania, 2008
- Neurology Fellowship, University of Michigan, 2009
- Masters in Clinical Research Design and Statistical Analysis, University of Michigan, 2011
- Center for Health and Research Transformation Policy Fellowship, University of Michigan, 2016
Honors & Awards
- Inaugural Fovette E. Dush Early Career Professor in Neurology
- American Academy of Neurology AB Baker Teacher Recognition Award
- Status Pedagogicus Award presented by University of Michigan Neurology Residents in recognition of teaching excellence
Dr. Brian Callaghan discussed his recent drug cost research on Michigan Radio's Stateside program. His research investigated the sharp rise in drug costs to patients suffering from neurologic diseases.