Friday, November 15, 2019

Neurology/Neuroscience Research Seminar - Presented by Dr. Kristy Townsend, Associate Professor, Neurobiology at the University of Maine - Friday, November 15th, 2019

12:00 PM to 1:00 PM

Biomedical Science Research Building (BSRB), Room 5515, 109 Zina Pitcher Place, Ann Arbor, MI 48109

The Regulation of Energy Balance Through Brain-Adipose Neural Communication

Proper innervation of adipose tissues is required for the maintenance of energy balance, and nerves in adipose are able to modulate processes such as lipolysis, adipogenesis, and thermogenesis. Surgical and chemical denervation studies have clearly demonstrated the importance of adipose innervation, but the diversity of adipose nerves, the roles of nerve products beyond norepinephrine in adipose function, and the neuroimmune control of adipose innervation are poorly understood. Recent advances in whole adipose depot imaging of the nerve supply and estimations of adipose nerve density have revealed changes that include adipose neuropathy (or loss of nerve supply; with aging, obesity, diabetes) and adipose nerve plasticity (or increase in nerve supply; with cold, exercise). We have also identified a subpopulation of monocyte/macrophages that hone to adipose upon cold exposure and express brain-derived neurotrophic factor (BDNF). Deletion of BDNF from the myeloid lineage led to a ‘genetic denervation’ of subcutaneous white adipose tissue, with lack of cold-induced UCP1 and an exacerbated response to a high-fat, high-sugar Diet. Our current work is exploring how adipose tissue lipid metabolites stimulate TRP-channel calcium uptake in adipose sensory nerves, as a potential fuel sensor to the brain.

Accreditation and Credit Designation:

The University of Michigan Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The University of Michigan Medical School designates this live activity for a maximum of 1.00 AMA PRA Category 1 Credit(s) ™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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Dr. Kristy Townsend

Kristy Townsend, PhD

Associate Professor, Neurobiology at the University of Maine