Areas of Interest
During cell division, cells divide their duplicated chromosomes equally between the two daughter cells by building a complex protein machine known as the kinetochore. How does this machine work at the molecular and biophysical level? What is the effect of defective kinetochore design and function in cancer cell biology? What are the operational and evolutionary constraints that shape its design? Can we build/reverse engineer a kinetochore-like machine that drives the equal division of synthetic chromosomes? Such a reverse engineered kinetochore can provide the transformative technology that will facilitate gene therapy.
Associated Grad Programs
- University of North Carolina-Chapel Hill, Postdoctoral Fellow, 12/2010
University of Michigan, Ph.D., 06/2004
University of Pune, BEng, 06/1999