Areas of Interest
The central nervous system is a highly intricate structure, composed of diverse subtypes of neurons and glia. Despite their crucial importance, neurons are highly vulnerable to damage and disease, which can lead to devastating neurodegenerative disorders.
Our lab research focuses on investigating cell type specification during the neurodevelopment and regeneration of neurons. Specifically, we study the molecular mechanisms regulating gene expression and how changes in gene expression drive cell fates during neurodevelopment and adult neurogenesis in the brain and retina. With high-throughput omic approaches and genetic tools, we are targeting genes at the top of gene networks to generate the desired cell types. Our goal is to develop cell-based therapies for neurodegenerative diseases.
Another lab research topic is to investigate the complex interactions between cell types, particularly between neurons and glia, during injuries and in neurodegeneration. We are interested in modulating these interactions to protect neurons and promote the regeneration of lost neurons.