Gilbert S. Omenn, M.D., Ph.D.

Gilbert Omenn, M.D., Ph.D.

Professor of Computational Medicine & Bioinformatics
Professor of Human Genetics
Professor of Molecular Medicine & Genetics
Professor of Public Health, School of Public Health
Harold T. Shapiro Distinguished University Professor

2065 Palmer Commons
100 Washtenaw Ave.
Ann Arbor, MI 48109-2218


Administrative Contact

Areas of Interest

Omenn’s current research interests are focused on cancer proteomics, splice isoforms as potential biomarkers and therapeutic tar- gets, and isoform-level and single-cell functional networks of transcripts and proteins.

He chairs the global Human Proteome Project of the Human Proteome Organization.

Honors & Awards

  • Distinguished University Professorship, University of Michigan
  • Abraham Flexner Lecturer, Vanderbilt University

Published Articles or Reviews

1. Omenn GS, Lane L, Lundberg EK, Beavis RC, Overall CM, Deutsch EW. Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications. J Proteome Res. 2016 Nov 4;15(11):3951-3960. PMID: 27487407

2. Deutsch EW, Overall CM, Van Eyk JE, Baker MS, Paik YK, Weintraub ST, Lane L, Martens L, Vandenbrouck Y, Kusebauch U, Hancock WS, Hermjakob H, Aebersold R, Moritz RL, Omenn GS. Human Proteome Project Mass Spectrometry Data Interpretation Guidelines 2.1. J Proteome Res. 2016 Nov 4;15(11):3961-3970.
PMID: 27490519

3. Omenn GS. Advances of the HUPO Human Proteome Project with broad applications for life sciences research. Expert Rev Proteomics 2016; Dec 22:1-3. PMID: 27935328

4. Omenn GS. The proteomes of the human eye, a highly compartmentalized organ. Proteomics 2016; Nov 9. doi: 10.1002/pmic.201600340. PMID: 27860232

5. Paik YK, Overall CM, Deutsch EW, Hancock WS, Omenn GS. Progress in the Chromosome-Centric Human Proteome Project as Highlighted in the Annual Special Issue IV. J Proteome Res. 2016 Nov 4;15(11):3945-3950. PMID: 27809547

6. Van Eyk JE, Corrales FJ, Aebersold R, Cerciello F, Deutsch EW, Roncada P, Sanchez JC, Yamamoto T, Yang P, Zhang H, Omenn GS. Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016. 

J Proteome Res. 2016 Nov 4;15(11):3979-3987. PMID: 27573249

7. Omenn GS. Strategies for Genomic and Proteomic Profiling of Cancers. Stat Biosci. 2016 Jun;8(1):1-7. PMID: 27594925

8. Qin S, Zhou Y, Gray L, Kusebauch U, McEvoy L, Antoine DJ, Hampson L, Park KB, Campbell D, Caballero J, Glusman G, Yan X, Kim TK, Yuan Y, Wang K, Rowen L, Moritz RL, Omenn GS, Pirmohamed M, Hood L. Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. J Proteome Res. 2016 Oct 7;15(10):3724-3740. PMID: 27575953

9. Panwar B, Menon R, Eksi R, Li HD, Omenn GS, Guan Y. Genome-Wide Functional Annotation of Human Protein-Coding Splice Variants Using Multiple Instance Learning. J Proteome Res. 2016 Jun 3;15(6):1747-53. PMID: 27142340

10. Li HD, Menon R, Eksi R, Guerler A, Zhang Y, Omenn GS, Guan Y. A Network of Splice Isoforms for the Mouse. Sci Rep. 2016 Apr 15;6:24507. PMID: 27079421

11. Miller AM, Omenn GS, Kean MA. The Impact of Alternative Payment Models on Oncology Innovation and Patient Care. Clin Cancer Res 2016 May 15;22(10):2335-41. PMID: 27087022

12. Sarntivijai S, Zhang S, Jagannathan DG, Zaman S, Burkhart KK, Omenn GS, He Y, Athey BD, Abernethy DR. Linking MedDRA(®)-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors. Drug Saf. 2016 Jul;39(7):697-707. PMID: 27003817

13. Menon R, Panwar B, Eksi R, Kleer C, Guan Y, Omenn GS. Computational Inferences of the functions of alternative/non-canonical splice isoforms specific to HER2+/ER-/PR- breast cancers, a Chromosome 17 C-HPP study. J Proteome Res 2015;14:3519-29. PMID: 26147891.

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