August 31, 2023

The Cheng lab publishes a research article in Nature Immunology

Molecular basis for potent B cell responses to antigen displayed on particles of viral size

Schematic of the library of liposomes engineered to display virus-like antigens (Ag) in a specific orientation and at a programmable density.

To understand how B cells signal in response to antigen display on viruses, researchers in the laboratory of Wei Cheng and their collaborators at UCSF engineered a set of virus-sized liposomes to display affinity mutants of the model antigen hen egg lysozyme (HEL), in the absence of nucleic acid cargo. Their studies of B cell responses to these synthetic particles led them to propose a novel signal transduction mechanism employed by B cells for recognition of virus-like antigens.

Research article in Nature Immunology