Greg Tall

Gregory Tall, PhD

Pharmacology
Research Interests:
G protein coupled receptors (GPCRs) activate heterotrimeric G proteins to control myriad signaling pathways and physiological processes.

G protein coupled receptors (GPCRs) activate heterotrimeric G proteins to control myriad signaling pathways and physiological processes. Our lab broadly studies these signaling circuits with current emphasis on delineating the function of adhesion GPCRs and Ric-8 proteins (folding chaperones for all G protein alpha subunits).  Adhesion GPCRs appear to couple extracellular shear force events to intracellular G protein signaling.  We use a wide range of approaches, including purified protein structure/function, cell culture models, GPCR drug screening, and transgenic animal models.