Areas of Interest
My research focus is to further the understanding of epigenetic mechanisms through the study of X-chromosome inactivation. X-inactivation equalizes X-linked gene expression between XY male and XX female mammals via transcriptional silencing of one of the two X-chromosomes in early female embryos. Once enacted in individual cells, X-inactivation is stably transmitted, meaning that all descendant cells maintain silencing of that X-chromosome. Understanding the memory mechanisms that are involved in X-inactivation will give us insight into transcriptional regulation genome-wide. These mechanisms are important in cell fate decisions during embryogenesis, in stem cell biology, and during disease progression.