Dr. Kryczek obtained her Ph.D. in immunology from Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland. She performed postdoctoral work in immunology at INSERM U-131 in Paris, France. In 2004, she joined the Section of Hematology and Medical Oncology at the Tulane University, New Orleans, LA. In 2006 she moved to Ann Arbor, University of Michigan.
Interaction between human immune cells and cancer cells
The etiology and progress of cancer is strongly associated with inflammatory environment. People with a chronic inflammatory process have an increased risk of developing several cancers suggesting the strong immune inflammatory conditioning. Although, extrinsic mechanisms provided by the tumor microenvironment are essential for forming the stem cell niche, the involvement of host immune system in this process is not understood. We believe that immune cells can actively and directly regulate the genetic and epigenetic mechanisms involved in tumor dissemination, relapse and metastasis.
Nagarsheth N, Peng D, Kryczek I. et al. PRC2 epigenetically silences Th1-type chemokines to suppress effector T cell trafficking in colon cancer. Cancer Res. 2015 Nov 13. doi:pii: canres.1938.2015.
Zhao E, Maj T, Kryczek I. et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat Immunol. 2015 Nov 2. doi: 10.1038/ni.3313.
Peng D, Kryczek I, Nagarsheth N. et al. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature 2015 Nov 12;527(7577):249-53.
Wan S, Kuo N, Kryczek I. et al. Myeloid cells in hepatocellular carcinoma. Hepatology. 2015 Oct;62(4):1304-12. doi: 10.1002/hep.27867.
Kryczek I, Lin Y, Nagarsheth N. et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 2014 May 15;40(5):772-84.
Wan S, Zhao E, Kryczek I et. al Tumor-associated macrophages produce interleukin 6 and signal via STAT3 to promote expansion of human hepatocellular carcinoma stem cells. Gastroenterology. 2014 Dec;147(6):1393-404. doi: 10.1053/j.gastro. 2014.08.039.
Mazur G, Butrym A, Kryczek I et. Al. Decreased expression of CXCR4 chemokine receptor in bone marrow after chemotherapy in patients with non-Hodgkin lymphomas is a good prognostic factor. PLoS One. 2014;9(5):e98194.
Cui TX, Kryczek I, Zhao L. et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity 2013 Sep 19;39(3):611-21.