Research in the Singer Lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease. Current projects in the laboratory focus on
- sexually dimorphic inflammatory responses to high fat diet and
- Mechanisms driving hematopoietic stem cell myeloid differentiation after high fat diet exposure. This work in mouse models uses bone marrow transplantation, stem-cell analysis techniques, and metabolic profiling. Understanding the immune physiology after high fat diet exposure in mice and translating these findings to pediatric obesity will lead to future therapeutic and dietary interventions.
Research Opportunities for Rotating Students
- Investigating sex differences in diet induced myelopoiesis.
- Understanding the dietary and metabolic ligands responsible for activating hematopoietic stem cells.
- Investigating the non-metabolic inflammatory sequlae of diet induced hematopoiesis.