Dan Beard

Daniel Beard, PhD

Carl J. Wiggers Collegiate Professor of Cardiovascular Physiology

NCRC 10-A122
2800 Plymouth Rd.
Ann Arbor, MI  48105

734-763-8040

Biography

Dr. Beard is a Professor in the Department of Molecular and Integrative Physiology and holds affiliate appointments in Biomedical Engineering and Emergency Medicine. His laboratory is focused on systems engineering approaches to understanding the biophysical and biochemical operation of physiological systems. Dr. Beard is the Director of the Virtual Physiological Rat (VPR) project, supported as an NIH National Center for Systems Biology, working to analyze, interpret, simulate, and ultimately predict physiological function in health and disease.

Dr. Beard earned an MS in Applied Mathematics and PhD in Bioengineering in 1997 under the supervision of Dr. James Bassingthwaighte at the University of Washington. After completing his PhD he conducted postdoctoral research at the Courant Institute of New York University, and as a Howard Hughes Medical Institute Postdoctoral Fellow. Before joining the University of Michigan, he was Professor of Physiology at the Medical College of Wisconsin.

Areas of Interest

Dr. Beard’s research interests center on: 

(1) Cardiac energy metabolism. One of the Beard lab’s significant contributions is the discovery of the primary pathway regulating mitochondrial ATP synthesis in the heart in vivo. In demonstrating that inorganic phosphate acts as the key feedback signal controlling the rate of oxidative phosphorylation in the heart, the group has disproved the entrenched theory that oxidative phosphorylation and cellular energetic state in the heart are maintained in the absence of a feedback mechanism. Current work focuses on the question of how the control of energy metabolism breaks down in heart failure, how loss of specific cytoplasmic pools in heart failure disrupts the energetic state, and if/how this metabolic failure determines the loss of mechanical function in heart failure.

(2) Oxidative metabolism and energetics in skeletal muscle. We investigating how oxidative ATP synthesis, coupled to physiological glucose disposal, is regulated in skeletal muscle and how this system becomes dysfunctional in type II diabetes.

(3) Regulation of coronary blood flow. Because the left ventricle extracts approximately 90% of oxygen from the coronary arterial blood supply, changes in myocardial work rate must be matched in lockstep with changes in myocardial perfusion. Because vascular signaling mechanisms integrate a number of parallel open-loop and feedback signals  to determine vessel tone, and because sympathetic innervation causes different responses in vessels in different locations in the coronary network, blood flow emerges as a consequence of phenomena that occur on multiple time and space scales.

(4) Etiology and sequalae of hypertension. Despite over 100 years of research, little is understood about the mechanisms causing hypertension. We are developing theoretical/computational models representing the short- and long-term mechanisms controlling arterial pressure, and using these models to guide experiments on animal models of hypertension. Specifically, models are used to generate hypotheses regarding the underlying mechanisms, and to design experiments to rule out competing hypotheses.

Selected Publications:

Beard DA, Liang SD, Qian H. Energy balance for analysis of complex metabolic networks. Biophys J. 83:79-86, 2002.

Beard DA. A biophysical model of the mitochondrial respiratory system and oxidative phos-phorylation. PLoS Comput Biol. 1:e36, 2005.

Wu, F., F Yang, KC Vinnakota, and D. Beard, Computer modeling of mitochondrial TCA cycle, oxidative phosphorylation, metabolite transport, and electrophysiology. J Biol Chem. 282:24525-24537, 2007.

Beard DA, and H Qian. Chemical Biophysics: Quantitative Analysis of Cellular Systems. Cambridge University Press, 2008.

Wu, F, EY Zhang, J Zhang, RJ Bache, and DA Beard. Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischemic hearts. J Physiol. 586:4193-4208, 2008.

Wu, F, J. Zhang, and DA Beard. Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl. Acad. Sci. USA 106:7143-7148, 2009.

Vinnakota, KC, and DA Beard. Stimulatory effect of calcium on respiration or NADH syn-thesis in intact rat heart mitochondria utilizing physiological substrates is not sufficient to explain respiratory control in vivo. J. Biol. Chem. 286:30816-30822, 2011.

Bazil, JN, F Qi, and DA Beard. A parallel algorithm for reverse engineering of biological networks. Integrative Biology 3:1215-1223, 2011.

Bugenhagen, SM, and DA Beard. Specification, construction, and exact reduction of state transition system models of biochemical processes. J. Chem. Phys. 137:154108, 2012.

Beard DA, Tautology versus Physiology in the Etiology of Hypertension. Physiology 28:270-271,, 2013.

Beard DA. Biosimulation: Simulation of Living Systems. Cambridge University Press, 2012.

Google Scholar Author’s page: http://scholar.google.com/citations?user=HkGuhUsAAAAJ&hl=en

 

Honors & Awards

  • Barry M. Goldwater Scholar
  • Howard Hughes Postdoctoral Fellowship
  • Top-10 Cited Paper in Journal of Theoretical Biology
  • Fellow of the American Physiological Society, Cardiovascular Section

Credentials

  • BS, Biomedical Engineering, Boston University, 1993
  • MS, Applied Mathematics, University of Washington, 1997
  • PhD, Bioengineering, University of Washington, 1997

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