Assistant Professor, Microbiology and Immunology
Effective tissue immunity requires effective clearance of noxious agents coupled with timely resolution of inflammation to allow tissue repair and regeneration, ability to remember the initial transgressor, and then prompt, apt responsiveness to subsequent re-encounter. All these processes need finely regulated, intimate crosstalk between the epithelial cells, the noxious stimuli (microbes, allergens, cancer cells), innate immune cells (like macrophages, neutrophils, etc.), and adaptive immune cells (like T cells). The Shenoy Lab of Barrier Immunobiology (SLOBI) is interested in understanding the extent of- and mechanisms underlying- how this intercellular crosstalk to- and from- lung epithelial cells remodels lung immunity to optimize immune resistance (noxious stimuli clearance) while ensuring/impeding tissue resilience (lung function) during health and disease.