Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin J, Saltiel AR, Inoki K. (2013) Inhibition of AMPK catabolic action by GSK3. Mol Cell, In press
Inoki K, Kim J, Guan KL. (2012) AMPK and mTOR in cellular energy homeostasis and drug targets. Annu Rev Pharmacol Toxicol 10, 381-400.
Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K. (2011) Redox regulates mTORC1 activity by modulating the TSC1/TSC2-Rheb pathway. J BiolChem 286, 326251-60.
Inoki K*, Mori H, Wang J, Suzuki T, Hong S, Yoshida S, Blattner SM, Ikenoue T, Rüegg MA, Hall MN, Kwiatkowski DJ, Rastaldi MP, Huber TB, Kretzler M, Holzman LB, Wiggins RC, Guan KL. (2011) mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy. (*corresponding) J Clin Invest. 121, 2181-96.
Narita M, Young A, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M. (2011) Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes. Science. 332, 966-70.
Inoki K, Ouyang H, Zhu T, Lindvall C, Wang Y, Zhang X, Yang Q, Bennett C, Harada Y, Stankunas K, Wang CY, He X, MacDougald OA, You M, Williams BO, and Guan KL (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968.
Inoki K, Corradetti MN, and Guan KL. (2005). Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37, 19-24.
Corradetti MN, Inoki K*, Bardeesy N, DePinho RA, and Guan KL*. (2004). Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18, 1533-1538. (*corresponding)
Inoki K, Li Y, Xu T, and Guan KL. (2003). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17, 1829-1834.
Inoki K, Zhu T, and Guan KL. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
Inoki K, Li Y, Zhu T, Wu J, and Guan KL. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-657.