Ling Qi, PhD

Professor, Molecular & Integrative Physiology
Professor, Internal Medicine, Division of Metabolism, Endocrinology & Diabetes

5325 Brehm Tower
1000 Wall St.
Ann Arbor, MI  48105

Biography

Dr. Qi received his undergraduate degree in Microbiology from the Fudan University, China in 1997 and his Ph.D. in Immunology with Dr. Suzanne Ostrand-Rosenberg from the University of Maryland in 2002. He was a postdoc fellow at Johns Hopkins University Medical School with Dr. Carol Greider (2001-2004) and then at the Salk Institute with Dr. Marc Montminy (2004-2007) prior to joining the faculty of Cornell University in 2007 as an assistant professor.  In 2013, he was promoted to associate professor. In 2016, he moved to the University of Michigan Medical School. Using a combination of knockout mouse and cell models, his laboratory aims to explore the physiological role of stress response and immune response in the context of human health and disease including obesity, diabetes and inflammatory bowel disease.

Areas of Interest

Our laboratory aims to explore the physiological role of endoplasmic reticulum (ER) homeostasis (with a special focus on both UPR and ERAD) and inflammation in the context of human diseases. We use genetic, immunological, molecular and cellular tools and approaches to produce new insights into disease pathogenesis, and to bring a standard excellence to all that we do as an individual scientist and as a laboratory. We have made significant contribution in the fields of physiological ER homeostasis and inflammation in health and diseases. In the last 8 years, we have published over 40 papers, including several seminal discoveries published in top journals, including Nat Cell Biology, Cell Metabolism, Developmental Cell, PNAS, Cell Reports, Diabetes, Mol Biol Cell and J Biol Chem. Our past achievements have demonstrated our desire to think outside the box, take the risk and develop breakthrough science. Our diverse research experience and knowledge in several research areas (immunology, cell biology, physiology and gastroenterology), together with our determination and dedication to scientific research and discovery, have provided an exceptional opportunity to accomplish our scientific goals and to make significant contributions to the understanding of human health and disease.

In addition to research, I am a dedicated teacher and mentor. I have trained several graduate students and postdoctoral fellows over the years, many of whom are now holding industrial and academic positions. My graduate students have successfully competed for prestigious HHMI International Scholar and AHA Predoctoral Fellowships. Moreover, I strive to bring the latest development in metabolism to undergraduate and graduate students in the course “Nutrient Metabolism” with over 120 students every year at Cornell. In May of 2014, I received the SUNY Chancellor’s Award for Excellence in Teaching, a top award for the best teachers in the NY State.

Honors & Awards

  • 1995 - Monsanto Development Award, Fudan University
  • 1996 - Director Oriental Development Award, Fudan University
  • 1997 - City Honored student, Shanghai Education Ministry
  • 2002 - Postdoctoral fellowship, Leukemia and Lymphoma Society
  • 2003 - The George Santos Award, Leukemia and Lymphoma Society
  • 2005 - Postdoctoral fellowship, Juvenile Diabetes Research Foundation
  • 2008 - New Investigator Award in Alzheimer's Disease, Rosalinde and Arthur Gilbert       Foundation/American Federation for Aging Research (AFAR)
  • 2008 - Junior Faculty Award, American Diabetes Association
  • 2011 - The Bio-Serv Award, American Society of Nutrition
  • 2012 - Career Development Award, American Diabetes Association
  • 2013 - The Thomas R. Lee Award, American Diabetes Association
  • 2014 - SUNY Chancellor’s Award for Excellence in Teaching, State University of New York
  • 2014 - Elected faculty speaker, Graduation ceremony, Division of Nutritional Sciences, Cornell University

Credentials

B.S., Fudan University, 1997

Ph.D., University of Maryland, 2002

Postdoctoral Fellow, Johns Hopkins University, 2004

Research Associate, Salk Institute, 2007

Published Articles or Reviews

Sun S, Lourie R, Cohen SB, Ji Y, Goodrich JK, Poole AC, Ley RE, Denkers EY, McGuckin MA, Long Q, Duhamel GE, Simpson KW, Qi L. Epithelial Sel1L is required for the maintenance of intestinal homeostasis. Mol Biol Cell. 2016 Feb 1; 27(3):483-90. PubMed PMID: 26631554.

Sun S*, Shi G*, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates Iii JR, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015 Dec;17(12):1546-55. PubMed PMID: 26551274; PubMed Central PMCID: PMC4670240.  (* contributed equally)

Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, Péterfy M, Long Q, Qi L. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014 Sep 2;20(3):458-70. PubMed PMID: 25066055; PubMed Central PMCID: PMC4156539.

Ji Y*, Sun S*, Goodrich JK, Kim H, Poole AC, Duhamel GE, Ley RE, Qi L. Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice. Cell Rep. 2014 Jul 10;8(1):137-49. PubMed PMID: 24953658; PubMed Central PMCID: PMC4103790. (* contributed equally)

Sun S*, Shi G*, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE, Kersten S, Yates JR 3rd, Long Q, Qi L. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E582-91. PubMed PMID: 24453213; PubMed Central PMCID: PMC3918815. (* contributed equally)

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