August 25, 2020

Shedding New Light on Cancer Cells’ Varied Response to Chemotherapy

Cell Reports

Jun Hee Lee (Associate Professor of Molecular & Integrative Physiology) and his research team carried out an analysis, done in three colon cancer cell lines, is believed to be the first to profile transcriptome-level changes in response to DNA damage across individual cells. 

Using a technique called single-cell RNA sequencing, Dr Lee and his associates were able to show for the first time how individual cells within a single population of cancer cells respond differently to the DNA damage caused by chemotherapy. The responses, they found, fall into three groups: activating genes that control cell death, cell division, or stress response, according to findings published in Cell Reports. You can learn more on M Health Lab.