You Lu, PhD

Research Investigator, Molecular & Integrative Physiology

5462 Brehm Tower

1000 Wall St.

Ann Arbor, MI 48105



Dr. Lu received his Ph.D. in Plant and Microbial Biology from the University of Minnesota in 2015. During his thesis research, Dr. Lu published the first de novo assembled reference genome for Gram-positive phytopathogenic bacteria Clavibacter insidiosus and characterized the mode of actions for a family of secreted virulence factors from this bacterial genus. Dr. Lu conducted postdoctoral research at the University of Minnesota on characterizing the regulatory roles of calcium signaling-related genes in fine tuning plant immunity using genetics and system biology approaches. Dr. Lu joined the University of Michigan in 2020 working with Dr. Ling Qi to study endoplasmic reticulum-associated degradation (ERAD) in the mammalian system.

Areas of Interest

Endoplasmic reticulum-associated degradation (ERAD) is essential for quality control of secreted and cell surface proteins and for maintaining ER homeostasis through selectively recognizing and degrading misfolded proteins. Our current understanding of how ERAD achieves these roles in diverse cellular contexts is limited by the dearth of knowledge on endogenous ERAD substrates. Dr. Lu is interested in identifying endogenous ERAD substrates using high-throughput approaches, including proteomics and next-gen sequencing, and in understanding how ERAD substrate specificity is achieved in a cellular context-dependent manner. The goals of Dr. Lu’s research are to establish a complete bioinformatic analysis framework for predicting ERAD substrates using the high-throughput data, to generate a reference atlas for ERAD activity and endogenous ERAD substrates across mammalian tissues and cell types, and to elucidate how ERAD modulates intercellular crosstalk in health and diseases.

Honors & Awards

Monsanto/University of Minnesota Multifunctional Agriculture Initiative Fellow 


Ph.D., Plant and Microbial Biology, University of Minnesota

Published Articles or Reviews

Lu Y, Tsuda K. Intimate Association of PRR- and NLR-Mediated Signaling in Plant Immunity. Mol Plant Microbe Interact. 34(1):3-14, 2021. PMID: 33048599

Qiu X, Macchietto MG, Liu X, Lu Y, Ma Y, Guo H, Saqui-Salces M, Bernlohr DA, Chen C, Shen S, Chen X. Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity. Int J Obes (Lond). 45(1):143-154, 2021. PMID: 33214705

Lu Y, Truman W, Liu X, Bethke G, Zhou M, Myers CL, Katagiri F, Glazebrook J. Different Modes of Negative Regulation of Plant Immunity by Calmodulin-Related Genes. Plant Physiol. 176(4):3046-3061, 2018. PMID: 29449432

Zhou M, Lu Y, Bethke G, Harrison BT, Hatsugai N, Katagiri F, Glazebrook J. WRKY70 prevents axenic activation of plant immunity by direct repression of SARD1. New Phytol. 217(2):700-712, 2018. PMID: 29076543

Lu Y, Ishimaru CA, Glazebrook J, Samac DA. Comparative Genomic Analyses of Clavibacter michiganensis subsp. insidiosus and Pathogenicity on Medicago truncatula. Phytopathology. 108(2):172-185, 2018. PMID: 28952422

Jordan NR, Dorn KM, Smith TM, Wolf KE, Ewing PM, Fernandez AL, Runck BC, Williams A, Lu Y, Kuzma J. A cooperative governance network for crop genome editing: The success of governance networks in other areas could help to find common ground for applying genome editing in agriculture. EMBO Rep. 18(10):1683-1687, 2017. PMID: 28928139

Hatsugai N, Igarashi D, Mase K, Lu Y, Tsuda Y, Chakravarthy S, Wei HL, Foley JW, Collmer A, Glazebrook J, Katagiri F. A plant effector-triggered immunity signaling sector is inhibited by pattern-triggered immunity. EMBO J. 36(18):2758-2769, 2017. PMID: 28811287

Lu Y, Hatsugai N, Katagiri F, Ishimaru CA, Glazebrook J. Putative Serine Protease Effectors of Clavibacter michiganensis Induce a Hypersensitive Response in the Apoplast of Nicotiana Species. Mol Plant Microbe Interact. 28(11):1216-26, 2015. PMID: 26075829

Lu Y, Samac DA, Glazebrook J, Ishimaru CA. Complete Genome Sequence of Clavibacter michiganensis subsp. insidiosus R1-1 Using PacBio Single-Molecule Real-Time Technology. Genome Announc. 3(3):e00396-15, 2015. PMID: 25953184

Truman W, Sreekanta S, Lu Y, Bethke G, Tsuda K, Katagiri F, Glazebrook J. The CALMODULIN-BINDING PROTEIN60 family includes both negative and positive regulators of plant immunity. Plant Physiol. 163(4):1741-51, 2013. PMID: 24134885