November 8, 2019

Shannon Estadt (Kahlenberg Lab) honored with Student Achievement Award!

Estadt will present her abstract "Interferon alpha promotes caspase-dependent apoptosis independently of reactive oxygen species in ultraviolet B exposed keratinocytes" at the ACR annual meeting

Estadt is working to understand the cell death pathways that are activated in keratinocytes by type I interferons and ultraviolet (UV) light to gain a better understanding of why patients with lupus experience photosensitivity. She has found that priming keratinocytes with interferons prior to exposure to UV light promotes caspase-8-dependent apoptosis, suggesting that interferon-driven extrinsic apoptosis may contribute to photosensitive responses. This work will hopefully lead to new treatments for SLE patients whose disease is flared by the sun.

Learn more about the Rheumatology Research Foundation's Student Achievement Award