Areas of Interest
The Uhler laboratory studies the role of neuronal signaling in human neurologic and psychiatric disorders. They have developed a number of tools to study gene expression in neurons derived from mouse and human stem cells. They derive various neuronal populations using the expression of neurogenic transcription factors to produce excitatory and inhibitory neurons. Using these neurons, they have defined signal transduction cascades for fibroblast growth factors (FGFs) and have identified genes regulated by FGFs that alter neuronal function.
The lab is currently deriving neuronal populations from patients with major depressive disorder (MDD) to determine if FGF signaling is altered in MDD. They are also characterizing the role of novel signaling proteins in the regulation of synaptic activity of human neurons in vitro.
Dr. Uhler serves as Co-Director of Human Stem Cell and Gene Editing Core (HSCGE).
Rapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing.
Tidball AM, Dang LT, Glenn TW, Kilbane EG, Klarr DJ, Margolis JL, Uhler MD, Parent JM. Stem Cell Reports. 2017 Sep 12;9(3):725-731. doi: 10.1016/j.stemcr.2017.07.003. Epub 2017 Aug 3.
HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. Cell Metab. 2016 Mar 8;23(3):505-16. doi: 10.1016/j.cmet.2016.01.004. Epub 2016 Feb 4.
For a complete list, visit https://www.ncbi.nlm.nih.gov/pubmed/?term=Uhler+MD%5BAuthor%5D