Areas of Interest
The Moon Lab is interested in how genes are expressed via the coordinated regulation of messenger RNAs at the levels of translation, localization, and decay. We study mRNA regulation in the context of human disease and stress, with a particular interest in neurological disorders. Our research aims to reveal the underlying principles and mechanisms governing mRNA in both health and disease to elucidate new therapeutic and diagnostic strategies.
Honors & Awards
- Chan Zuckerberg Initiative Collaborative Pairs Pilot Project Award (2020)
- Brain & Behavior Research Foundation NARSAD Young Investigator (2019)
- University of Michigan Neuroscience Scholars Program (2019)
- University of Michigan Biological Sciences Scholars Program (2019)
Credentials
- Howard Hughes Medical Institute and University of Colorado-Boulder, Post-doctoral Fellow (2014-19)
- Colorado State University, Ph.D. Pathology (2014)
- Fort Lewis College, B.S. Chemistry and Biology (2008)
Published Articles or Reviews
- English AM, Green KM, Moon SL. A (dis)integrated stress response: genetic diseases of eIF2α regulators. Wiley Interdisciplinary Reviews: RNA. 2021 Aug 31;e1689.
- Moon SL, Morisaki T, Stasevich TJ, Parker R. Coupling of translation quality control and mRNA targeting to stress granules. J Cell Biol. 2020 Aug 3;219(8):e202004120.
- Burke JM, Moon SL, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019 Sep 19;75(6):1203-1217.e5.
- Moon SL, Morisaki T, Khong A, Lyon K, Parker R, Stasevich TJ. Multicolour single-molecule tracking of mRNA interactions with RNP granules. Nat Cell Biol. 2019 Feb;21(2):162-168.