Areas of Interest
Despite obvious pathological protein aggregation in Alzheimer’s disease (i.e., amyloid-β plaques and tau tangles), little is known about mislocalization of other proteins in AD pathology and how that mislocalization may be affecting neuronal function; protein mislocalization in normal aging brains has yet to be characterized. Using resilient gene candidates identified from transcriptomic studies of cognitively resilient and susceptible AD-BXD mice (polygenic mouse model of human AD), my postdoctoral research is focused on using high-resolution confocal microscopy to investigate the subcellular localization pattern of resilience-related protein targets in hippocampal and frontal cortical neural circuits of AD-BXD mice and human tissue. These data will be critical for fully elucidating cellular mechanisms of cognitive resilience and susceptibility in normal aging and Alzheimer’s disease.
Clinical Interests
Despite obvious pathological protein aggregation in Alzheimer’s disease (i.e., amyloid-β plaques and tau tangles), little is known about mislocalization of other proteins in AD pathology and how that mislocalization may be affecting neuronal function; protein mislocalization in normal aging brains has yet to be characterized. Using resilient gene candidates identified from transcriptomic studies of cognitively resilient and susceptible AD-BXD mice (polygenic mouse model of human AD), my postdoctoral research is focused on using high-resolution confocal microscopy to investigate the subcellular localization pattern of resilience-related protein targets in hippocampal and frontal cortical neural circuits of AD-BXD mice and human tissue. These data will be critical for fully elucidating cellular mechanisms of cognitive resilience and susceptibility in normal aging and Alzheimer’s disease.
Honors & Awards
- Outstanding poster, Michigan Alzheimer’s Disease Research Center’s 3rd Annual Disease Research Symposium, Grand Rapids, MI (2019)
- Nominated for the Outstanding Graduate Student Instructor Award, Rackham Graduate School, University of Michigan, Ann Arbor, MI (2017)
- Finalist for the Program in Biomedical Science’s Graduate Student Award for Excellence in Teaching, University of Michigan, Ann Arbor, MI (2016)
- Outstanding poster, XIVth Molecular and Cellular Biology of Plasminogen Activation International Workshop, Notre Dame, IN (2013)
Credentials
- B.A., History, University of Michigan (2008)
- Ph.D., Molecular and Integrative Physiology, University of Michigan (2018)
Published Articles or Reviews
- Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA. Identification of a neurovascular signaling pathway regulating seizures in mice. Annals of Clinical and Translational Neurology. 2015;2(7):722-738.
- Stevenson TK and Lawrence DA. Characterization of tissue plasminogen activator expression and trafficking in the adult murine brain. eNeuro. 2018;5(4).
- Rodriguez G, Moore SJ, Neff RC, Glass ED, Stevenson TK, Stinnett GS, Seasholtz AF, Murphy GG, Cazares VA. Deficits across multiple behavioral domains align with susceptibility to stress in 129S1/SvImJ mice. Neurobiol Stress. 2020;13:100262.
- Stevenson TK, Moore SJ, Murphy GG, Lawrence DA. Tissue plasminogen activator in central nervous system physiology and pathology: from synaptic plasticity to Alzheimer’s disease. Semin Thromb Hemost. 2022;48(3):288-300.