Areas of Interest
1) Tri-glial maladaptation in neurodevelopmental disorders and epilepsy
2) Molecular, cellular, and circuit mechanisms of epileptogenesis and hyperexcitablity in the brain.
3) Sudden unexpected death in epilepsy and mTOR hyperactivation
Clinical Interests
Dr. Wang’s primary clinical interests involve the medical and surgical treatment of refractory epilepsy, MRI-negative epilepsy, and the pharmacology of anti-seizure medications. He believes the ultimate goal of epileptologists is to improve a patient’s quality of life and restore their self-confidence, which is accomplished by knowledge and theory in epilepsy on the one hand and practical wisdom on the other.
Published Articles or Reviews
- Manent JB, Wang Y, Chang Y, Paramasivam M, LoTurco JJ: Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nat Med 15(1):84-90, 2009. PM19098909/PMC2715867
- Wang Y, Ji T, Nelson AD, Glanowska K, Murphy GG, Jenkins PM, Parent JM: Critical roles of αII spectrin in brain development and epileptic encephalopathy. J Clin Invest 128(2): 760-773, 2018. PM29337302/PMC5785268
- Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y: Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Ann Neurol 84(1): 140-146, 2018. PM30080265/PMC6119494
- Yang T, Hu ST, Chang WC, Kao HY, Wang Y: Perineuronal nets degradation and parvalbumin interneuron loss in a mouse model of DEPDC5-related epilepsy. Dev Neurosci, 2022 (accepted with minor revision).