Publications

 

2021

Research Articles

  1. Shi B, Wang W, Korman B, Kai L, Wang Q, Wei J, Bale S, Marangoni RG, Bhattacharyya S, Miller S, Xu D, Akbarpour M, Cheresh P, Proccissi D, Gursel D, Espindola-Netto JM, Chini CCS, de Oliveira GC, Gudjonsson JE, Chini EN, Varga J. Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis. iScience. 2021 January 22;24(1):101902. PubMed PMID: 33385109; PubMed Central PMCID: PMC7770554; DOI: 10.1016/j.isci.2020.101902.
  2. Prasov L, Bohnsack BL, El Husny AS, Tsoi LC, Guan B, Kahlenberg JM, Almeida E, Wang H, Cowen EW, De Jesus AA, Jani P, Billi AC, Moroi SE, Wasikowski R, Almeida I, Almeida LN, Kok F, Garnai SJ, Mian SI, Chen MY, Warner BM, Ferreira CR, Goldbach-Mansky R, Hur S, Brooks BP, Richards JE, Hufnagel RB, Gudjonsson JE. DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation. Journal of medical genetics. 2021 January 25. PubMed PMID: 33495304; DOI: 10.1136/jmedgenet-2020-107447.
  3. Simpson CL, Tokito MK, Uppala R, Sarkar MK, Gudjonsson JE, Holzbaur ELF. NIX initiate mitochondrial fragmentation via DRP1 to drive epidermal differentiation. Cell Rep. 2021 Feb 2;34(5):108689. doi:10.1016/j.celrep.2021.108689. PMID: 33535046; PMCID: PMC7888979.
  4. Patrick MT, Zhang H, Wasikowski R, Prens EP, Weidinger S, Gudjonsson JE, Elder JT, He K, Tsoi LC. Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies. The Journal of allergy and clinical immunology. 2021 March;147(3):857-869.e7. PubMed PMID: 33485957; PubMed Central PMCID: PMC7825803; DOI: 10.1016/j.jaci.2021.01.006
  5. Sule G, Abuaita BH, Steffes PA, Fernandes AT, Estes SK, Dobry C, Pandian D, Gudjonsson JE, Kahlenberg JM, O'Riordan MX, Knight JS. Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus. J Clin Invest. 2021 Apr 1;131(7):e137866. doi: 10.1172/JCI137866. PMID: 33561013; PMCID: PMC8011900.
  6. Patrick MT, Bardhi R, Raja K, He K, Tsoi LC. Advancement in predicting interactions between drugs used to treat psoriasis and its comorbidities by integrating molecular and clinical resources. J Am Med Inform Assoc. 2021 Jun 12;28(6):1159-1167. doi: 10.1093/jamia/ocaa335. PMID: 33544847; PMCID: PMC8200269.
  7. Turnier JL, Pachman LM, Lowe L, Tsoi LC, Elhaj S, Menon R, Amoruso MC, Morgan GA, Gudjonsson JE, Berthier CC, Kahlenberg JM. Comparison of Lesional Juvenile Myositis and Lupus Skin Reveals Overlapping Yet Unique Disease Pathophysiology. Arthritis Rheumatol. 2021 Jun;73(6):1062-1072. doi: 10.1002/art.41615. Epub 2021 May 2. PMID: 33305541; PMCID: PMC8274390.
  8. Davis FM, Tsoi LC, Melvin WJ, denDekker A, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu C, Moore BB, Kunkel SL, Daugherty A, Lu HS, Gudjonsson JE, Gallagher KA. Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms. J Exp Med. 2021 Jun 7;218(6):e20201839. doi: 10.1084/jem.20201839. PMID: 33779682; PMCID: PMC8008365
  9. Ma F, Hughes TK, Teles RMB, Andrade PR, de Andrade Silva BJ, Plazyo O, Tsoi LC, Do T, Wadsworth MH 2nd, Oulee A, Ochoa MT, Sarno EN, Iruela-Arispe ML, Klechevsky E, Bryson B, Shalek AK, Bloom BR, Gudjonsson JE, Pellegrini M, Modlin RL. The cellular architecture of the antimicrobial response network in human leprosy granulomas. Nat Immunol. 2021 Jul;22(7):839-850. doi: 10.1038/s41590-021-00956-8. Epub 2021 Jun 24. PMID: 34168371; PMCID: PMC8579511.
  10. Grachtchouk M, Liu J, Hutchin ME, Harms PW, Thomas D, Wei L, Wang A, Cummings D, Lowe L, Garlick J, Sciubba J, Chinnaiyan AM, Verhaegen ME, Dlugosz AA. Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling. Carcinogenesis. 2021 Aug 19;42(8):1100-1109. doi: 10.1093/carcin/bgab050. PMID: 34117865; PMCID: PMC8374060.
  11. Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, Wasikowski R, Smith KM, Honore P, Scott VE, Maverakis E, Kahlenberg JM, Wang G, Ward NL, Harms PW, Gudjonsson JE. Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris. JCI Insight. 2021 Oct 22;6(20):e151911. doi: 10.1172/jci.insight.151911. PMID: 34491907; PMCID: PMC8564909

Reviews

  1. Hile GA, Kahlenberg JM. Immunopathogenesis of skin injury in systemic lupus erythematosus. Current opinion in rheumatology. 2021 March 1;33(2):173-180. PubMed PMID: 33315653; DOI: 10.1097/BOR.0000000000000770.
  2. Sirobhushanam S, Lazar S, Kahlenberg JM. Interferons in Systemic Lupus Erythematosus. Rheum Dis Clin North Am. 2021 Aug;47(3):297-315. doi: 10.1016/j.rdc.2021.04.001. Epub 2021 Jun 10. PMID: 34215365; PMCID: PMC8254852.
  3. Yan D, Gudjonsson JE, Le S, Maverakis E, Plazyo O, Ritchlin C, Scher JU, Singh R, Ward NL, Bell S, Liao W. New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine. J Invest Dermatol. 2021 Sep;141(9):2112-2122.e3. doi: 10.1016/j.jid.2021.02.764. Epub 2021 Jul 22. PMID: 34303522; PMCID: PMC8384663.

2020

Research Articles

  1. Greenberg EN, Marshall ME, Jin S, Venkatesh S, Dragan M, Tsoi LC, Gudjonsson JE, Nie Q, Takahashi JS, Andersen B. Circadian control of interferon-sensitive gene expression in murine skin. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5761-5771. doi: 10.1073/pnas.1915773117. Epub 2020 Mar 4. PMID:32132203; PMCID: PMC7084068.
  2. denDekker AD, Davis FM, Joshi AD, Wolf SJ, Allen R, Lipinski J, Nguyen B, Kirma J, Nycz D, Bermick J, Moore BB, Gudjonsson JE, Kunkel SL, Gallagher KA. TNF-α regulates diabetic macrophage function through the histone acetyltransferase MOF. JCI Insight. 2020 Mar 12;5(5):e132306. doi:10.1172/jci.insight.132306. PMID: 32069267; PMCID: PMC7141388.
  3. Kwock JT, Handfield C, Suwanpradid J, Hoang P, McFadden MJ, Labagnara KF, Floyd L, Shannon J, Uppala R, Sarkar MK, Gudjonsson JE, Corcoran DL, Lazear HM, Sempowski G, Horner SM, MacLeod AS. IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection. Sci Adv. 2020 Apr 1;6(14):eaay3245. doi: 10.1126/sciadv.aay3245. PMID: 32270034; PMCID: PMC7112749.
  4. Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL. KLK6 expression in skin induces PAR1 mediated psoriasiform dermatitis and inflammatory joint disease. J Clin Invest. 2020 Jun 1;130(6):3151-3157. doi:10.1172/JCI133159. PMID: 32155135; PMCID: PMC7260032.
  5. Quan T, Xiang Y, Liu Y, Qin Z, Yang Y, Bou-Gharios G, Voorhees JJ, Dlugosz AA, Fisher GJ. Dermal Fibroblast CCN1 Expression in Mice Recapitulates Human Skin Dermal Aging. J Invest Dermatol. 2020 Aug 13;. doi: 10.1016/j.jid.2020.07.019. [Epub ahead of print] PubMed PMID: 32800875; NIHMSID:NIHMS1621326.
  6. Tsoi LC, Gharaee-Kermani M, Berthier CC, Nault T, Hile GA, Estadt SN, Patrick MT, Wasikowski R, Billi AC, Lowe L, Reed TJ, Gudjonsson JE, Kahlenberg JM. IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions. JCI Insight. 2020 Aug 20;5(16):e139558. doi: 10.1172/jci.insight.139558. PMID: 32644977; PMCID: PMC7455118.
  7. Davis FM, Tsoi LC, Wasikowski R, denDekker A, Joshi A, Wilke C, Deng H, Wolf S, Obi A, Huang S, Billi AC, Robinson S, Lipinski J, Melvin WJ, Audu CO, Weidinger S, Kunkel SL, Smith A, Gudjonsson JE, Moore BB, Gallagher KA. Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair. JCI Insight. 2020 Sep 3;5(17):e138443. doi: 10.1172/jci.insight.138443. PMID: 32879137; PMCID: PMC7526451.
  8. Richer J, Hill HL, Wang Y, Yang ML, Hunker KL, Lane J, Blackburn S, Coleman DM, Eliason J, Sillon G, D'Agostino MD, Jetty P, Mongeon FP, Laberge AM, Ryan SE, Fendrikova-Mahlay N, Coutinho T, Mathis MR, Zawistowski M, Hazen SL, Katz AE, Gornik HL, Brummett CM, Abecasis G, Bergin IL, Stanley JC, Li JZ, Ganesh SK. A Novel Recurrent COL5A1 Genetic Variant Is Associated With a Dysplasia-Associated Arterial Disease Exhibiting Dissections and Fibromuscular Dysplasia. Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):2686-2699. doi: 10.1161/ATVBAHA.119.313885. Epub 2020 Sep 17. PMID: 32938213.
  9. Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, van der Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier C, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP. Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight. 2020 Oct 2;5(19):e139930. doi: 10.1172/jci.insight.139930. PMID: 32853177; PMCID: PMC7566715.
  10. Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD. Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-a therapy. JCI insight. 2020 October 2;5(19). PubMed PMID: 32841223; PubMed Central PMCID: PMC7566733; DOI: 10.1172/jci.insight.139932.
  11. Hughes TK, Wadsworth MH 2nd, Gierahn TM, Do T, Weiss D, Andrade PR, Ma F, de Andrade Silva BJ, Shao S, Tsoi LC, Ordovas-Montanes J, Gudjonsson JE, Modlin RL, Love JC, Shalek AK. Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies. Immunity. 2020 Oct 13;53(4):878 894.e7. doi:10.1016/j.immuni.2020.09.015. PMID: 33053333; PMCID: PMC7562821.
  12. Moldovan LI, Tsoi LC, Ranjitha U, Hager H, Weidinger S, Gudjonsson JE, KjemsJ, Kristensen LS. Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles. ExpDermatol. 2020 Oct 28. doi: 10.1111/exd.14227. Epub ahead of print. PMID:33113213.
  13. Patrick MT, Stuart PE, Zhang H, Zhao Q, Yin X, He K, Zhou XJ, Mehta NN, Voorhees JJ, Boehnke M, Gudjonsson JE, Nair RP, Handelman SK, Elder JT, Liu DJ, Tsoi LC. Causal Relationship and Shared Genetic Loci between Psoriasis and Type 2 Diabetes through Trans-Disease Meta-Analysis. The Journal of investigative dermatology. 2020 December 30. PubMed PMID: 33385400; DOI: 10.1016/j.jid.2020.11.025.

Reviews

  1. Shao S, Wang G, Maverakis E, Gudjonsson JE. Targeted Treatment for Erythrodermic Psoriasis: Rationale and Recent Advances. Drugs. 2020 Apr;80(6):525-534. doi: 10.1007/s40265-020-01283-2. PMID: 32180204; PMCID:PMC7167352.
  2. Hile G, Kahlenberg JM, Gudjonsson JE. Recent genetic advances in innate immunity of psoriatic arthritis. Clin Immunol. 2020 May;214:108405. doi: 0.1016/j.clim.2020.108405. Epub 2020 Apr 2. PMID: 32247832.
  3. Shao S, Gudjonsson JE. Epigenetics of Psoriasis. Adv Exp Med Biol. 2020;1253:209-221. doi: 10.1007/978-981-15-3449-2_8. PMID: 32445097.
  4. Hile GA, Gudjonsson JE, Kahlenberg JM. The influence of interferon on healthy and diseased skin. Cytokine. 2020 Aug;132:154605. doi: 10.1016/j.cyto.2018.11.022. Epub 2018 Dec 6. PMID: 30527631; PMCID: PMC6551332.
  5. Uppala R, Tsoi LC, Harms PW, Wang B, Billi AC, Maverakis E, Michelle Kahlenberg J, Ward NL, Gudjonsson JE. "Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis. Cell Mol Immunol. 2020 Aug 19. doi: 10.1038/s41423-020-0519-3. Epub ahead of print. PMID: 32814870.
  6. Jiang Y, Tsoi LC, Billi AC, Ward NL, Harms PW, Zeng C, Maverakis E, Kahlenberg JM, Gudjonsson JE. Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin. JCI Insight. 2020 Oct 15;5(20):e142067. doi: 10.1172/jci.insight.142067. PMID: 33055429; PMCID: PMC7605526.

Commentaries

  1. Zeng C, Kahlenberg JM, Gudjonsson JE. IL-17A Softens the Skin: Antifibrotic Properties of IL-17A in Systemic Sclerosis. J Invest Dermatol. 2020 Jan;140(1):13-14. doi: 10.1016/j.jid.2019.07.678. PMID: 31864428.
  2. Billi AC, Sarkar MK, Gudjonsson JE. When bugs and drugs conspire: driving acneiform skin toxicity. J Clin Invest. 2020 Mar 2;130(3):1090-1092. doi:10.1172/JCI133787. PMID: 32015232; PMCID: PMC7269584.
  3. Kahlenberg JM. Rethinking the Pathogenesis of Cutaneous Lupus. J Invest Dermatol. 2021 Jan;141(1):32-35. doi: 10.1016/j.jid.2020.05.077. Epub 2020 Jun 27. PMID: 32605817; PMCID: PMC7752835.
  4. Maz MP, Michelle Kahlenberg J. Cutaneous and systemic connections in lupus. Curr Opin Rheumatol. 2020 Nov;32(6):583-589. doi: 10.1097/BOR.0000000000000739. PMID: 32826479.

2019

Research Articles

  1. Wolf SJ, Estadt SN, Theros J, Moore T, Ellis J, Liu J, Reed TJ, Jacob CO, Gudjonsson JE, Kahlenberg JM. Ultraviolet light induces increased T cell activation in lupus-prone mice via type I IFN-dependent inhibition of T regulatory cells. J Autoimmun. 2019 Sep;103:102291. doi: 10.1016/j.jaut.2019.06.002. Epub 2019 Jun 24. PubMed PMID: 31248690; PMCID: PMC6708464.
  2. Kimball AS, Davis FM, denDekker A, Joshi AD, Schaller MA, Bermick J, Xing X,  Burant CF, Obi AT, Nysz D, Robinson S, Allen R, Lukacs NW, Henke PK, Gudjonsson JE, Moore BB, Kunkel SL, Gallagher KA. The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair. Immunity. 2019 Aug 20;51(2):258-271.e5. doi: 10.1016/j.immuni.2019.06.015. Epub 2019 Jul 23. PubMed PMID: 31350176; PubMed Central PMCID: PMC6703945.
  3. Berthier CC, Tsoi LC, Reed TJ, Stannard JN, Myers EM, Namas R, Xing X, Lazar  S, Lowe L, Kretzler M, Gudjonsson JE, Kahlenberg JM. Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes. J Clin Med. 2019 Aug 17;8(8). pii: E1244. doi: 10.3390/jcm8081244. PubMed PMID 31426521; PMCID: PMC6723404.
  4. Shao S, Tsoi LC, Sarkar MK, Xing X, Xue K, Uppala R, Berthier CC, Zeng C, Patrick M, Billi AC, Fullmer J, Beamer MA, Perez-White B, Getsios S, Schuler A, Voorhees JJ, Choi S, Harms P, Kahlenberg JM, Gudjonsson JE. IFN-γ enhances cell mediated cytotoxicity against keratinocytes via JAK2/STAT1 in lichen planus. Sci Transl Med. 2019 Sep 25;11(511). pii: eaav7561. doi: 10.1126/scitranslmed.aav7561. PubMed PMID: 31554739.  PMCID: PMC7285657.
  5. Munger E, Choi H, Dey AK, Elnabawi YA, Groenendyk JW, Rodante J, Keel A, Aksentijevich M, Reddy AS, Khalil N, Argueta-Ameya J, Playford MP, Erb-Alvarez J, Tian X, Wu C, Gudjonsson JE, Tsoi LC, Jafri MS, Sandfort V, Chen MY, Shah SJ, Bluemke DA, Lockshin B, Hasan A, Gelfand JM, Mehta NN. Application of Machine Learning to Determine Top Predictors of Non-calcified Coronary Burden in Psoriasis: an Observational Cohort Study. J Am Acad Dermatol. 2019 Oct 30. Pii  S0190-9622(19)32983-4. doi: 10.1016/j.jaad.2019.10.060. [Epub ahead of print] PubMed PMID: 31678339.
  6. Sirobhushanam S, Parsa N, Reed TJ, Berthier CC, Sarkar MK, Hile GA, Tsoi LC, Banfield J, Dobry C, Horswill AR, Gudjonsson JE, Kahlenberg JM. Staphylococcus aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by IFN- Mediated Barrier Disruption. J Invest Dermatol. 2020 May;140(5):1066-1074.e4. doi: 10.1016/j.jid.2019.11.016. Epub 2019 Dec 23. PMID: 31877319; PMCID: PMC7183889.
  7. Tsoi LC, Rodriguez E, Stölzl D, Wehkamp U, Sun J, Gerdes S, Sarkar MK, Hübenthal M, Zeng C, Uppala R, Xing X, Thielking F, Billi AC, Swindell WR, Shefler A, Chen J, Patrick MT, Harms PW, Kahlenberg JM, Perez White BE, Maverakis E, Gudjonsson JE, Weidinger S. Progression of acute to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses. J Allergy Clin Immunol. 2020 May;145(5):1406-1415. doi: 10.1016/j.jaci.2019.11.047. Epub 2019 Dec 28. PMID: 31891686; PMCID: PMC7214216.

Reviews

  1. Billi AC, Gudjonsson JE, Voorhees JJ. Psoriasis: Past, Present, and Future. J  Invest Dermatol. 2019 Nov;139(11):e133-e142. doi: 10.1016/j.jid.2019.08.437. PubMed PMID: 31648690; PubMed Central PMCID: PMC6989032.

Letter to Editor: Case citation

  1. Park JE, Yonet-Tanyeri N, Vander Ende E, Henry AI, Perez White BE, Mrksich M, Van Duyne RP. Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS). Nano Lett. 2019 Oct 9;19(10):6862-6868. doi: 10.1021/acs.nanolett.9b02070. Epub 2019 Oct 1. PubMed PMID: 31545611; PubMed Central PMCID: PMC7398609.
  2. Toussi A, Merleev A, Barton VR, Le ST, Marusina A, Luxardi G, Kirma J, Xing X, Adamopoulos IE, Fung MA, Raychaudhuri SP, Shimoda M, Gudjonsson JE, Maverakis E. Transcriptome mining and B cell depletion support a role for B cells in psoriasis pathophysiology. J Dermatol Sci. 2019 Dec;96(3):181-184. doi:10.1016/j.jdermsci.2019.11.006. Epub 2019 Nov 19. PMID: 31780313.