Functional Analytics Core

We provide systems biology analyses, disease- and cytokine-specific gene expression profiling, and training to support skin-related research:

• Service 1: Disease case/comparison of repository genomics (Single cell RNA-seq) to aid in creating disease mouse models with bioinformatics analysis
• Service 2: Disease case/comparison of genomics in Rodent vs repository human genomics (single cell RNA-seq) to aid in creating disease mouse models with bioinformatics analysis
• Service 3: Disease case/comparison of genomics (Spatial RNA-seq) in human tissue with bioinformatics analysis
• Service 4: Disease case/comparison of genomics (Single cell RNA-seq) in human tissue and blood with bioinformatics analysis
• Service 5: Consultation with UM-SBDRC Functional Analytics Core 
• Service 6: Protocol Development UM-SBDRC Functional Analytics Core

We provide CRISPR/Cas9 genome editing services in keratinocytes for generation of both knock-out and knock-in keratinocytes, as well as functional characterization of mutant keratinocyte lines.

The U-M SBDRC Skin Genes Query supports comparison of normal and disease gene expression in human and mouse skin utilizing datasets supplied by SBDRC members. This tool is available to all UM SBDRC members and requires University of Michigan level-1 account verification. If you are unable to access this tool and are a current UM SBDRC member, please email Carmel McKeon ([email protected]) for assistance.

If you are interested in the FAC bioinformatics services, please email [email protected].
If you are interested in the FAC cell line services, please email [email protected].