Animal Modeling Core

The role of the Animal Modeling Core (AMC) is to facilitate the development and use of state-of-the-art mouse models and to provide relevant consultation, training, and troubleshooting for UM-SBDRC Center members interested in pursuing skin-related studies in mice.

We will provide hands-on assistance with the following services and training:

  • Consultation on the design and development of project-specific GEMMs, including conventional, Cre-inducible, doxycycline-inducible, and conditional mutant mice.
  • Guidance for producing and validating mouse models, including transgene construction, verification, genotyping, and GEMM production; screening; breeding, strain establishment, and validation.
  • In vivo manipulation, including transgene induction protocols, UV irradiation, induction of skin inflammation by exogenous agents, bleomycin-induced fibrosis, and orthotopic xenografts and allografts.
  • GEMM phenotyping, including proper tissue collection and processing; morphologic, biochemical, and molecular characterization; cross-species validation; and establishment of GEMM-derived primary cultures and immortalized cell lines, taking into consideration key experimental variables including body site, gender, and age.

Contact Us:

If you are interested in the Animal Modeling Core services, please email 


Dr. Anj Dlugosz

Andrzej Dlugosz, MD

Associate Director, University of Michigan Skin Biology and Diseases Resource-based Center
Associate Director, UM-SBDRC Administrative Core
Director, UM-SBDRC Animal Modeling Core

Dr. J. Michelle Kahlenberg

J. Michelle Kahlenberg, MD, PhD

Associate Director, UM-SBDRC Animal Modeling Core