April 19, 2021

Attacking aortic aneurysms before they grow

New basic science research shows what happens when you inhibit JMJD3 through both genetics and pharmacology.

A new study investigates a genetic culprit behind abdominal aortic aneurysm, a serious condition that puts people at risk of their aorta rupturing – a potentially deadly event.

Finding a viable genetic target for AAA could change the game, says senior author Katherine Gallagher, M.D., a vascular surgeon and an associate professor of surgery and microbiology and immunology at Michigan Medicine, the academic medical center of the University of Michigan. (Read more).

Paper cited: "Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms," Journal of Experimental MedicineDOI: 10.1084/jem.20201839