Research By Topic

Research and clinical faculty are actively engaged in many areas of research to continually advance the effectiveness and reach of emergency medical care, as well as prevention.  We invite you to explore our recent and current research by topic.

See all grants via Michigan Experts

Critical Care

07/01/2017 – 06/30/2021
1R01HL133129-01A1, National Heart Lung and Blood Institute (NHLBI)
Neumar, Robert W (Co-PI)
ECPR After Prolonged Cardiac Arrest: Targeting Mechanisms of the No-Reflow

9/27/2016-06/30/2021
1K12HL133304-01, Physician Scientist Award, National Heart, Lung, and Blood Institute
Neumar, Robert (PI)
Pinsky, David J (Co-PI)
K12: Career Development in Emergency Critical Care Research (website)

1/2016-12/2017
HUM00113781, Whitaker intramural grant from U of Michigan 

Cole, Michael (PI)
In-Situ Critical Care Simulation to Improve Critical Patient Care by Senior Medical Students

This project employs medical simulation to instruct senior level medical students on essential aspects in the care of the critically ill patient. This project is novel in that we utilize simulation to focus on multiple facets of care involving ICU-level patients including: therapeutics, pathophysiology, nontechnical skills and procedural competence. These are skills that contribute to competency-based learning that has become an essential component in modern medical education and this method of instruction provides students a unique method for students to experience autonomy in clinical care to aid in competency based assessment.

07/01/2015-06/30/2018
15SDG25830030, Scientist Development Grant, American Heart Association
Jinka, Tulasi (PI)
Mechanistic Strategies for Optimizing Post-Cardiac Arrest Targeted Temperature Management
The overall objective of this application is mechanistic optimization of intra- and post-cardiac arrest hypothermic targeted temperature management.
Co-Investigator: Neumar, Robert 

09/20/2013-06/30/2018
R01HL123227-03, National Heart Lung and Blood Institute (NHLBI)
Yannopolous, Demetris (PI)
Reperfusion Injury Protection Strategies during Basic Life Support
Subcontract with University of Minnesota. The goal if this study is to test novel ischemic post conditioning cardiopulmonary resuscitation (CPR) methods to mitigate cerebral and cardiac reperfusion injury after cardiac arrest.
Co-Investigator: Neumar, Robert

11/01/2007-03/31/2018
R44 HL091606-05, National Heart, Lung and Blood Institute (NHLBI)
Neumar, Robert W (Co-PI)
Commercialization of a Simple Automatic Perfusion System for ECPR
This study proposes to address the device limitations of using ECPR by developing a simple to use, highly integrated, cardio-pulmonary support device. In addition the study proposes to automate advanced resuscitation strategies of ischemic post conditioning, mild hypothermia control, normocarbia, and arterial hyperoxia prevention giving practitioners new capabilities to optimize the initial reperfusion conditions and minimize reperfusion injury to the brain. 

10/2015-11/2016
16-PAF01621, Jawbone
Tiba, Mohamad Hakam (PI)
Noninvasive evaluation and continuous measurement of arterial blood pressure during hemodialysis using a novel wearable device
Evaluation of non-invasive wearable device utilization to predict intradialytic hypotension during dialysis. 

07/01/2015-06/30/2017
15GRNT25890002, Grant-in-Aid, American Heart Association
Neumar, Robert W (PI)
Optimizing Extracorporeal Cardiopulmonary Resuscitation (ECPR) for Refractory Cardiac Arrest
This study tests the hypothesis that early administration of unfractionated heparin during prolonged cardiac arrest will mitigate intravascular coagulation and improve recovery of cardiac and neurologic function with ECPR in a large animal model. 

06/2015-12/2015
15-PAF06146, Renal Research Institute, LLC
Heung, Michael (PI)
Comparison of Respiratory Induced Limb Bioimpedance Changes with Inferior Vena Cava
Diameter Changes to Assess Intravascular Volume Status in Patients Undergoing Hemodialysis
Evaluation of novel non-invasive method (bioimpedance) utilization to predict intradialytic hypotension during dialysis.
Co-Investigator: Mohamad Hakam Tiba

05/01/2015-04/30/2016
Michigan Translational and Commercialization Fund, Michigan Economic Development Council
Ward, Kevin (Co-PI)
Microscale Whole Blood Coagulation Assay Platform
This project is creating a small mechanics platform for point of care testing of blood visco and thromboelastic properties.

05/01/2015-04/30/2016
Michigan Translational and Commercialization Fund, Michigan Economic Development Council
Ward, Kevin (Co-PI)   
Micro Gas Chromatography and Breathomics for Acute Point-of-Care Diagnostics project
The project is creating a small gas chromatography platform for bedside detection and analysis of exhaled markers of acute lung disease and systemic inflammation

04/01/2015-03/31/2016
G016079, Massey TBI Initiative
Kayvan Najarian (PI)
Computer-Aided System for Automated Analysis of CT Brain Images in Traumatic Brain Injury
The aim of this proposal is to develop a mathematical model for TBI that predicts ICP as well as the success / failure of different interventions.

02/2015-02/2016
G016123, Massey Family Foundation
Rajajee, Krishna/ Ward, Kevin (Co-PI)
Novel Noninvasive Methods of Intracranial Pressure Assessment: Seeing the Brain through the Eyes
Evaluation of two novel non-invasive methods (ultrasound and bioimpedance) to monitor and track changes in intra-cranial pressure in post TBI patients
Co-Investigator: Tiba, Mohamad Hakam

2014-2015 Massey Traumatic Brain Injury Research Initiative 2015
Belle, Ashwin/ Ward, Kevin/ Rajajee, Venkatakrishna/ Najarian, Kayvan (Co-PI)
Multi-parameter goal-directed analytics for continuous monitoring and early detection of hemodynamic instability to avoid secondary brain insults and injuries in TBI patients
This project focuses avoiding the potential for secondary brain injury in traumatic brain injury patients.  This is done by developing algorithms and machine learning models which utilize a variety of physiological data captured from the patients to predict chances of cerebral pressure fluctuations.

01/15/2015-01/15/2016
325356, Michigan Translational Research and Commercialization (MTRAC)
Belle, Ashwin/ Ward, Kevin/ Najarian, Kayvan/ Daniels Rodney (Co-PI)
Advanced Hemodynamic Assessment and Monitoring Using Computer-Aided Analysis of ECG Signals
This project proposes the development of a continuous patient monitoring system, which uses electrocardiograph signals to monitors the patients’ hemodynamic status as well as predict the potential impending hemodynamic compromise. 

01/15/2015-01/15/2016
325356, Michigan Translational Research & Commercialization (MTRAC)
Kayvan Najarian (PI)
Computer-Aided System for Automated Analysis of Coronary Angiograms
This project designs and tests algorithms for automated analysis and quantitative assessment of coronary angiogram.

2014/08/01-2015/08/01
N0191256, Michigan Center for Integrative Research in Critical Care (MCIRCC)
Najarian, Kayvan/ Belle, Ashwin/ Oldham, K. (Co-PI)
Non-Invasive Portable System for Continuous Monitoring of Sepsis
This project proposes a sensor that captures the vascular tone of the arterial system and directly reflects the mechanical pressure of pulsation caused by the flow of blood in the arteries. Advanced analytics are then developed to recognize patterns within the sensor data, which are indicative of sepsis or impending septic shock. The proposed portable technology can be used for home monitoring and prediction of sepsis among patents discharged from hospital. 

02/2014-01/2015
N017668, (MTRAC) for Life Sciences Program
Tiba, Mohamad Hakam (PI)
Dynamic Respiratory Impedance Volume Evaluation (DRIVE)
Utilization of novel non-invasive method (bioimpedance) to evaluate volume status in health subjects and mildly sick subjects in the Emergency department.

03/01/2014-03/01/2015
N018035, Michigan Translational Research and Commercialization
Kayvan Najarian (PI)
A Portable Real-time Monitoring System for Detection of Cardiovascular Events
The proposed system designs the hardware and algorithms for a peizo-electric sensing system that collects and processes a novel pressure signal to extract clinically-useful information such as HRV and PPV.

06/01/2015-06/01/2016
1542124, National Science Foundation
Kayvan Najarian (PI)
PFI: AIR:TT: Computer-Aided Decision Support System for Pelvic and Abdominal Traumatic Injuries (REU)
This Research Experience for Undergraduate (REU) Supplement allows students to participate in creating and validation of a proof-of-concept for a computer-aided trauma decision making product.

01/04/2015-07/01/2016
1500124, National Science Foundation
Kayvan Najarian (PI)
PFI:AIR:TT: Computer-Aided Decision Support System for Pelvic and Abdominal Traumatic Injuries
The aim of this proposal is to design a proof-of-concept product based on the computer-aided design system developed with prior grants from National Science Foundation.

1/30/2014-12/31/2016
14-PAF03993, William Davidson Foundation
Ward, Kevin (PI)
Fast Forward Medical Innovation
This grant provides important funding to supplement the University of Michigan’s new Fast Forward Medical Innovation initiative allowing investment in development of early stage technologies to accelerate their commercialization as well as develop important educational initiatives around entrepreneurialism. 

11/2013-12/2015
14-PAF05256, St. Michaels Hospital
Neumar, Robert/ Tiba, Mohamad Hakam (Co-PI)
Multi-laboratory Study of Epinephrine in Experimental Cardiac Arrest
To evaluate effects of continuous vs. bolus infusion of epinephrine during CPR on coronary perfusion pressure and survival post cardiac surgery.

01/2015-06/2015
15-PAF03360, Baxter Healthcare Corporation
Tiba, Mohamad Hakam (PI)
Comparison of Respiratory Induced Limb Bioimpedance Changes with Inferior Vena Cava Diameter Changes to Assess Intravascular Volume Status
Utilization of novel non-invasive method (bioimpedance) to assess volume status in critically ill patients in the ICU or in patients during hemodialysis.

1/30/2015-7/30/2015
15-PAF03360, Baxter Healthcare Corporation
Ward, Kevin (PI)
Comparison of Respiratory Induced Limb Bioimpedance with Inferior Vena Cava Diameter Changes to Assess Intravascular Volume
This grant will assess the ability of limb impedance as an accurate surrogate of functional intravascular volume in the management of dialysis and critical care patients.

1/31/2014-1/30/2015
Michigan Translational and Commercialization Fund, Michigan Economic Development Council
Ward, Kevin (Co-PI)
Dynamic Respiratory Impedance Volume Evaluation
This project is developing an impedance method to evaluated real-time changes in limb impedance as a continuous surrogate of diameter changes in the inferior vena cava.

1/31/2014-1/30/2015
Michigan Translational and Commercialization Fund, Michigan Economic Development Council
Ward, Kevin (PI)
Airway Support Device
This project is developing a device that provides noninvasive airway support during procedural sedation to reduce the incidence of airway obstruction
Role: PI

01/29/2007-01/10/2014
ONR N000140710526, Department of Defense: Office of Naval Research 
Ward, Kevin (PI)
Novel Acute Rescue Strategies using Non-pulmonary Oxygenation
This project explores the creation of special compounds and delivery methods that provide tissue oxygenation via nonpulmonary routes.

06/2008-12/2013
W81XWH09C0117, Department of Defense: U.S Army: Phase IISTTR Grant
Najarian, Kayvan/Ward, Kevin (Co-PI)
Bioinformatic Based Wearable Critical Care Monitor
The aims of this study are to develop a small wearable monitor for combat using advanced bioinformatic data analysis

04/01/2010-03/31/2013
R21 NS069951-02, National Institute of Neurological Disorders and Stroke (NINDS)
Neumar, Robert W (PI)
Inositol (1,4,5)-trisphosphate receptor proteolysis in ischemic brain injury
The goal of this study project to elucidate the functional consequences of Inositol (1,4,5)-triphosphate receptor proteolysis cause by calpains and caspases

01/10/2011-01/09/2013
W81XW H-1120089, Department of Defense: US Army Medical Research and Materiel Command
Ward, Kevin (PI)
Defining Platelet Function during Polytrauma
This project will characterize longitudinal platelet function in human victims of polytrauma.

Design of Clinical Trials

4/01/2014 –3/31/2019
R25 NS08824801, NIH/NINDS
Meurer, William (PI)  
The project supports development pre-conference webinars, a 3-day in-person conference, with post conference webinars and other activities in an integrated, longitudinal, small group experience. An advanced track in clinical trial simulation and flexible adaptive design is planned for the later years that allows investigators to evaluate progress on specific outcome measures (such as number of grants funded) and internal performance metrics (knowledge and competency in clinical trial planning and conduct within course participants.

09/2010-08/2015
5U01NS073476-03, National Institutes of Health
Barsan, William (PI)
Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design
The use of adaptive trial designs for confirmatory phase clinical trials has the prospect for accelerating the process of drug and device acceptance and regulatory approval.  Four adaptive clinical trials will be designed for potential use in the NETT.  The project will evaluate the process and potential barriers to use of adaptive designs for confirmatory phase clinical trials.
Co-Investigators: Meurer, William; Silbergleit, Robert

Global Health

11/30/2010 - 8/31/2015
1R24TW00889901, NIH Fogarty
Barsan, William/ Cunningham, Rebecca/ Donkor (Co-PI) 
Ghana Emergency Medicine Collaborative Training Program
The 5 year project will generate a cadre of well-trained EM personnel who will sustain training of EM providers in Ghana. Approximately 100 nurses, 100 residents and 40 EMS providers will undergo training over the 5 year period. 900 medical students will be educated about EM. Exposure to research methodology will produce residency graduates fluent in research methods and capable conducting locally-based research. Ultimately, the in-country program will improve retention of EM providers and decrease preventable acute injury and illness related deaths in Ghana. 
Co-Investigator: Maio, Ronald

Health Services

08/01/2015 – 07/31/2020
K08, HS024160, AHRQ/Agency for Healthcare Research and Quality
Kocher, Keith (PI)
Understanding the Causes and Consequences of National Variation in Emergency Department Hospitalization Practices
The specific aims of this project are:  1) To determine patient clinical and hospital factors associated with variability in ED hospitalizations; 2) To determine how patient non-clinical factors influence variability in ED hospitalizations; 3) To evaluate the effect of ED hospitalization patterns on outcomes and costs.

7/2015-6/2017
Emergency Medicine Foundation (EMF)
Abir, Mahshid (PI)
Investigating Patient-Centered Interventions to Reduce Asthma-Related Hospitalizations

11/2015-10/2016
Michigan Department of Health and Human Services (MDHHS)
Abir, Mahshid (PI)
A Mixed Methods Study to Inform Quality Measures for Medical Control Authority Structure and Performance

08/01/2014 – 07/31/2016
1R21AG043739-01A1, National Institutes of Health (NIH)/National Institute on Aging (NIA)
Abir, Mahshid (PI)
The Effect of High Inpatient Occupancy on Outcomes for Elderly Medicare Patients
Using administrative discharge data from the state of California for the years 1998-2012, assessing the impact of high occupancy on a number of outcomes for elderly Medicare patients including in-hospital mortality, out-of-hospital mortality, hospital length of stay, 2 and 4 week post-discharge emergency department visits, and 30-day readmissions. 

05/01/2014 – 02/29/2016
R21, 13-PAF06141, NIH/National Institute on Aging SubK-NIH-DHHS-US through a consortium with University of Iowa
Wright (PI)
Understanding Racial and Geographic Disparities in Hospital Observation Care
The specific aims of this project are:  1) To determine the extent to which disparities in observation care are driven by patient and hospital level factors; 2) To assess the association between observation care and patient-centered outcomes by race and rurality. 
Co-Investigator: Kocher, Keith

01/01/2015 – renewed annually
Value Partnership Programs, Blue Cross Blue Shield of Michigan/Blue Care Network 
Kocher, Keith (PI)
Michigan Emergency Department Improvement Collaborative (MEDIC)
The specific aims of this project are:  1) To establish and develop an emergency care collaborative of participating EDs across the state of Michigan; 2) To capture and analyze population based ED quality and efficiency metrics; 3) To drive improvements in processes of care and clinical outcomes for ED patients.  

03/01/2011 – 02/28/2015
Agency for Healthcare Research and Quality (AHRQ)
Freed (PI)
The Quality Measurement, Evaluation, Testing, Review and Implementation Consortium (Q-METRIC)
This program conducted studies on the development, assessment, refinement and testing of quality measures as directed by the Agency for Healthcare Research and Quality.
Co-Investigator: Macy, Michelle (Topic Lead for the overuse of neuroimaging for children with headache or seizure)

2014-2015  
U.S. Department of Health and Human Services, Assistant Secretary for Preparedness and Response
Development of a Peer Assessment Tool for Mass Casualty Incidents
Developed and pilot-tested a tool that can be used in the aftermath of mass casualty incidents to evaluated a community’s level of preparedness; Contributed to conceptualzing the project, project design, development of the tool and pilot-test protocols, interpreting findings, leading project focus groups, conducting one-on-one interviews with study participants.
Co-Investigator: Abir, Mahshid

2014-present
HHSO100201200075G, Department of Health and Human Services (DHHS)/Office of the Assistant Secretary for Preparedness and Response (ASPR)
Wasserman, Jeffrey/ Ringel, Jeanne (Co-PI)
National Health Security Strategy Development, Implementation, and Evaluation Support Services
Co-Investigator involved in leading the development of strategic Objective 4 of ASPR’s “Leadership Update” and part of a team of researchers developing a tool to measure the level of preparedness of health care coalitions in responding to mass casualty incidents and disasters, contribute methodological and content expertise in developing related metrics.
Co-Investigator: Abir, Mahshid

Department of Health and Human Services, Office of the Secretary-Subcontracts Contract No. 20101309, State of Michigan Department of Community Health
Wang, Stewart (PI)
State Burn Coordinating Center
Led a multi-disciplinary team of researchers at the University of Michigan in developing a computer-simulated model
of burn surge capacity at the University of Michigan Health System (UMHS), conceptualized study and model design, data collection and interpretation, manuscript preparation.
Co-Investigator: Abir, Mahshid                                                                                   

08/01/2012 – 06/30/2014
Faculty Development Award, Department of Emergency Medicine, University of Michigan
Kocher, Keith (PI) 
Factors Associated with Growth in Emergency Department Visit Volume in the United States
The specific aims of this project are:  1) To characterize national trends in ED visit volumes over time by hospital location; and 2) To determine if neighboring EDs located in similar competitive markets drive visit volume. 

09/30/2010-07/31/2013
3-R01-HS-019712, AHRQ
Marcin, J (PI)
Factors Associated with Quality of Care Delivered to Children in US ED
The purpose of the AHRQ study is to evaluate the validity of an implicit review instrument and apply the instrument to Pediatric Emergency care delivered in a variety of settings.
Site-PI and Reviewer: Rogers, Alexander

2012-2013
Emergency Medicine Action Fund (EMAF)
Kellermann, Art (PI)
Calculating the Value of Emergency Medicine
Part of a team of researchers who conducted this mixed-methods study;  Contributed both content and methodological expertise to the analyses of large administrative datasets, developing the study’s focus group and one-on-one interview guides, conducting one-on-one interviews, interpreting both qualitative and quantitative study findings, preparing final project report.
Co-Investigator: Abir, Mahshid

2011-2012
U.S. Department of Health and Human Services, Assistant Secretary for Preparedness and Response
Developing Performance Measures on Healthcare Surge Capacity
Part of a team of researchers who developed and pilot tested scalable game-based assessment of health facility surge capacity; Contributed both content and methodological expertise in developing tool metrics and exercise protocols.
Co-Investigator: Abir, Mahshid

Injury and Injury Prevention

02/2016-present
6-PAF04035, American Academy of Pediatrics Resident Community Access to Child Health (CATCH) Grant

Hashikawa, Andrew/ Alpert, Aviva (Co-PI)
Helmet Smart at Head Start - Intervention to Improve Helmet Safety at a Head Start program. 

Collaborative Project with American Academy of Pediatrics, Safe Kids, and Head Start to develop an educational program for preschool children and their caregivers that includes an interactive educational event, with each child receiving a new helmet and caregivers learning how to properly fit a helmet on their child using an educational, audiovisual podcast we designed.  Before and after watching the podcast, caregivers completed a short survey that assessed attitudes towards and practices surrounding helmet use for their preschool-aged child.  Finally, by using a database maintained by the Head Start preschool, we identified children with missing health screenings and use the event to connect these children to needed services.

08/01/2012-07/31/2017
5 R49 CE 002099 04, Centers for Disease Control & Prevention
Cunningham, Rebecca (PI and Center Director)
The University of Michigan Injury Center
The University of Michigan Injury Center is a comprehensive ICRC that integrates all phases of injury prevention and control, across the spectrum of age groups. The Center is supplemented by the vast (and unique in the Midwest) educational, research, outreach and policy resources of the University of Michigan (U-M), Wayne State University (WSU) and Michigan State University (MSU), whose injury personnel are ready to address the burden of injury in Michigan and the Great Lakes Region. The mission of the Center is to conduct high-quality injury research and training, to translate scientific discoveries into practice and policy, and to reduce injuries, violence and related disabilities.
Biostatistician: Goldstick, Jason

08/01/2013-03/31/2018
R01 DA03518302, NIDA
Cunningham, Rebecca(contact PI)/ Walton, Maureen / Buu, Anne (multiple-PI)
Measurement and Methodology for Daily Patterns of Drug Use and Related Behaviors
In this study which continues to follow the cohort recruited in FYI- 1 from the Emergency department oversampling violently injured youth. The goal is to develop cost-effective measurement and cutting-edge methodology to collect and analyze daily process data. Specific aims: 1) Develop cutting-edge statistical methodology to address the missing data issue of prospective measurements (IVR and TM) and to examine reactivity and validity based on daily patterns of health risk behaviors (drug/alcohol use, violence, and HIV risk sexual behavior). 2) Conduct an experimental study using a high risk sample from the FYI longitudinal study to evaluate compliance, reactivity and validity under different measurements and assessment schedules

9/1/2014 – 8/31/2017
CDC, Centers for Disease Control & Prevention
Zimmerman, Marc (PI)
Youth Violence Prevention through Environmental Design
This study is designed to test the effects of environmental change on youth violence.
Associate Director and Co-Investigator: Cunningham, Rebecca
Co-Investigator: Goldstick, Jason

10/01/2014 - 07/31/2017
R49 CE002099, CDC
Walton, Maureen/ Cunningham, Rebecca (Co-PI) 
Translation of an Intervention for Violence among Adolescents in Emergency Departments
This is a small project that is part of an Injury Research Center (PI: Cunningham). The proposed translation study will determine the reach, effectiveness, adoption, implementation, and maintenance of the SafERteens BI when delivered by ED social workers as part of routine clinical practice in the ED, using technology to facilitate training (YouTube videos) and structure intervention delivery (via iPads).
Co-Investigator: Carter, Patrick

08/2014 - 07/2017
U01-MH-104311-01, NIMH
King, Cheryl (PI)/ Rogers, Alexander (Site PI)
Emergency Department Screen for Teens at Risk for Suicide (ED-STARS)
The overall objective is to develop a suicide risk profile and computerized adaptive screening tool for predicting suicide attempts.  The optimal screening tool developed in this collaborative project will have the potential to be disseminated nationwide to enhance the capacity of emergency departments to identify and effectively triage youth at acute risk for suicide attempts.
Co-Investigator: Cunningham, Rebecca

02/01/2015-01/31/2017
R03 DA 039003 01, NIDA 
Goldstick, Jason/ Cunningham, Rebecca (Multiple-PI's)
Substance Use, Violence, and HIV Risk: Age-specific Risk Factors and Drivers of Comorbidity
This grant describes a secondary analysis of data from the NIDA-funded Flint Adolescent Study (PI: Zimmerman), where we proposed to use existing methods – and develop new statistical methods (and associated software) – to uncover age-specific effects and behavioral comorbidities of substance use.

05/01/2013-02/28/2017
5R01 DA 033397-03, NIDA
Ilgen, Mark (PI) 
Medical Marijuana: Longitudinal trajectories in use, pain and functioning
The proposed study will identify a cohort of 800 individuals who are seeking medical marijuana and examine their substance use, pain (functioning, and health service use over the course of two years.
Co-Investigator: Cunningham, Rebecca

02/20/2012 – 01/31/2017
K23, National Institute of Child Health and Human Development (NICHD)
Macy, Michelle (PI) 
Brief ED Intervention to Increase Size-Appropriate Child Passengers Restraint Use
This study aims to advance research training of the PI required to develop and evaluate an ED-based intervention utilizing MI techniques and patient-centered (e.g., targeted and tailored) print materials to promote the correct and consistent use of size-appropriate child passenger restraints

04/01/2015-09/30/2016
1500124, National Science Foundation
Najarian, Kayvan (PI)
PFI: AIR-TT: Prototype Scale-up for Traumatic Pelvic and Abdominal Injury Decision Support System
This project will develop a computational image analysis approach to detection of traumatic injuries coupled with clinical decision support tools.
Co-Investigator: Ward, Kevin

01/2015 – 09/30/2016
Michigan Office of Highway Safety Planning (OHSP)
Macy, Michelle (Multiple-PI)
Mapping Child Passenger Safety Needs and Resources for Michigan’s Children
This study utilizes geospatial techniques to determine the location of children at risk for suboptimal child safety seat use throughout the state of Michigan and assess the distribution of child passenger safety resources from the Michigan Office of Highway Safety Planning, the child passenger safety needs and resources throughout the state of Michigan. 

07/15/2015 – 07/15/2016
UM M-TRAC KickStart Award
Macy, Michelle (PI)
The CarSeat Compass
This pilot funding supports the development of a functional prototype of a car seat selection and installation application for use by child passenger safety technicians, healthcare providers, and parents.

06/15/2015-05/31/2016
G1501RRG, American Academy of Family Physicians Foundation
Singh, Vijay (PI)
Evaluation of Intimate Partner Violence Training with Theater Performance in Medical Education
We are conducting a cross-over randomized controlled trial of theater performance or didactic session on intimate partner violence (IPV), with health care providers receiving pre- and post-training surveys to assess IPV screening self-efficacy, importance, knowledge, intentions, and behaviors.

05/01/2015– 4/30/2016
CDC/University of Michigan Injury Center 
Firearm Violence Prevention: Smartphone Technology for Daily Data Collection and Remote Therapy among High-risk ED Youth Pilot Project Carter, Patrick (PI) 
This is a pilot project funded through the U-M Injury Center. The proposed study will enroll high-risk ED youth from the Emergency Department in Flint, Michigan with two primary aims: 1) To describe cognitive factors, motivations and substance use and their associations with high-risk firearm behaviors, collected via a two-way text messaging system on a daily basis for 3-months; and 2) To develop and pilot test an 8-session smartphone based remote therapy intervention (Motivational Interviewing + Cognitive Behavioral Therapy + Care Management) to decrease pro-violence attitudes and increase self-efficacy for avoiding violent among a sub-sample of youth who have past 6-month substance misuse and seeking ED care for assault.

10/30/2016-05/31/2017
VAW/01, World Health Organization
Singh, Vijay (PI)
Developing and pilot testing violence against women training curricula with evaluation methods for healthcare providers and students in low-to-middle income countries
We are creating an innovative, multi-disciplinary training program for healthcare providers to address intimate partner violence in low-to-middle income countries (LMIC). This program will consist of classroom material and online video modules tailored by a series of focus groups to fit the needs of LMIC settings.

01/01/2013-01/31/2016
NIJ-2012-3097, National Institute of Justice (NIJ)
Rogers, Alexander/ Jing Wen Hu (Co-PI)
Development and Validation of a New Pediatric Head Injury Assessment Tool for Possible Child Abuse Cases Considering Subject-specific Child Head Anatomy
This grant is the pilot work for part of the current application. It supports patient identification and scene investigation for pediatric falls in young children presenting to University of Michigan. Thus far approximately 100 cases have been prospectively identified at this single site. This work speaks to the feasibility of the current grant. Dr. Rogers is a Co-PI and responsible for the patient identification and accrual for the project.

01/01/2015-12/31/2015
UL1TR000433, MICHR
Buckley, Lisa (PI)
A Brief Emergency Department Intervention to Improve Transportation Safety
The overall goal of the research is to translate the social psychology theory of bystander intervention (TOBI) to encourage protecting friends in drink driving and riding with a drink driver situation. This theory is used in conjunction with cognitive behavioral techniques and a brief motivational interviewing approach to create an intervention for delivery in the ED to reduce alcohol-involved motor vehicle crashes. The research will involve: (1) Developing technology resources for the intervention (SPIY-ED), including a computer-based module that delivers a tailored intervention combined with a cell phone application for receipt of booster material and (2) Determining the acceptability, usability, and perceived utility of SPIY-ED among young alcohol users.
Co-Investigator: Carter, Patrick

05/18/2010-12/31/2016
G0903RS, American Academy of Family Physicians Foundation
Singh, Vijay (PI)
Surveying and Interviewing Male Primary Care Patients for Perpetration of Domestic Violence
This project assesses the prevalence of intimate partner violence (IPV) perpetration and victimization and correlates with demographics, mental health and substance use, gun ownership, and mindfulness among male family medicine patients. This study also uses interviews to understand intervention options through IPV perpetrator's experiences with screening and treatment.

09/30/2010-09/29/2015
1U01 CE00195705, Centers for Disease Control & Prevention
Zimmerman, Marc (PI)
Michigan Youth Violence Prevention Center
Assistant Director and Co-Investigator: Cunningham, Rebecca

08/01/2014 - 07/31/2015
CDC/University of Michigan Injury Center 
How Do Multiple Male Peer Passengers Affect Male Adolescents’ Risky Driving Behaviors: A Driving Simulator Evaluation Pradhan, Anuj (pilot study PI)
This study will examine risky driving behaviors of male teenagers driving alone as compared to when driving with multiple passengers; examine distraction and inattention behaviors of male teenagers when driving alone as compared to when driving with multiple friends as passengers; and characterize the interaction dynamics of multiple male teenage occupants of a vehicle.
Co-Investigator: Carter, Patrick

12/2013 - 05/2015

R01 AA021900 
Linakis, James (PI)/ Rogers, Alexander (Site PI)
Teen Alcohol Screening in the Pediatric Emergency Care Applied Research Network (ASSESS).  The primary objective is to validate a two-question screening tool for the early detection of alcohol use and problems.  The new screen, developed by the National Institute of Alcohol Abuse and Alcoholism (NIAAA) is an empirically based screen designed to predict current and future negative consequences of alcohol use.  The study will validate the NIAAA two-question screen with 12-17 year olds in U.S. pediatric emergency departments (PED).

06/01/2013 – 05/31/2015
University of Michigan Injury Center/Toyota Motor Engineering & Manufacturing North America
Macy, Michelle (PI)
Identifying High-Risk Areas for Child Safety Seat Misuse: A Geographic Information System Approach
This study assessed the feasibility of using participant address information collected at child safety seat inspections to identify areas with high utilization of these programs and areas with high rates of child safety seat misuse. 

05/01/2014 – 04/30/2015
University of Michigan Health System Fostering Innovations Grants
Macy, Michelle (PI)
Car Seat Compass: Which Child Safety Seat is Right for your Child?
The goal of this project is to develop an application that can guide parents toward the size-appropriate restraint for their child today and help anticipate the timing of transitions from rear-facing to forward-facing, car seat to booster seat, and booster seat to seat belt.

05/01/2014 – 04/30/2015
University of Michigan Center for Research on Learning and Teaching (CRLT) Investigating Student Learning (ISL) Grant
Cohn, Amy (PI)
Assessing the Impact of Cross-Disciplinary, Project-Focused, Action-Based Immersive Learning Experiences in Healthcare and Engineering
This project evaluated experiences of participants in an immersive summer program that brought teams of engineering and healthcare students together to work on real-world patient safety projects in clinical settings. 
Co-Investigator: Macy, Michelle

06/15/2009-09/30/2014
R01 AA01812205, NIAAA
Cunningham, Rebecca/ Walton, Maureen (Multiple-PI's)
Optimizing Brief Alcohol Intervention for Underage Drinkers in the ER Project U- Connect
The study develops, refines and conducts a RCT of tailored motivational BIs (Computer-delivered brief intervention and Therapist-delivered brief intervention) for youth with at- risk alcohol use seen in the ED compared to enhanced usual care (EUC)
Post-Doctoral Research Fellow:  Carter, Patrick

01/01/2013 - 06/30/2014
M Cubed Research Initiative
Carter, Patrick (PI) 
Improving Trauma Triage Models for Motor Vehicle Crashes
This study examines advanced automated collision notification data to understand how current EMS rapid response triage protocol may be able to integrate such data into new triage algorithms to improve patient care.               

05/01/2009-04/30/2014
R01 DA024646-05/NIDA  
Cunningham, Rebecca (PI)
Substance Use and Violent Injury among Youth in an Urban ED- Services & Outcomes
Specific aims are: (1) To describe characteristics of youth (ages 14-24) who report illicit drug use presenting to an urban ED for an acute violent injury; (2) To identify the trajectories of participants’ interactions with health services during the two years following their ED visit and the key characteristics associated with types of service use (substance use treatment; mental health; medical/ ED) and barriers to these services; (3) To measure two-year outcomes for this cohort and to identify key socio-demographic and clinical characteristics of youth with drug use, who have poor outcomes in the two years after ED visit for intentional injury and other medical care.
Post-Doctoral Research Fellow: Carter, Patrick

07/01/2013 – 04/01/2014
Insurance Institute for Highway Safety 
Bingham, Raymond (PI) 
Evaluate the Effect of Repealing Michigan Motorcycle Helmet Law on Crash-related Fatalities and Injury Outcomes
This three phase study examines state police crash data, statewide hospital trauma registry data and roadside helmet use observation data to characterize the effect of Michigan’s partial helmet law repeal on helmet use, in- and out-of hospital mortality, and head injury.
Co-Investigator: Carter, Patrick

05/18/2011-08/31/2013
UL1RR024986, Michigan Institute for Clinical and Health Research
Yoshihama, Mieko (PI)
A Community-generated, Socio-culturally Relevant Intimate Partner Violence Training: A Feasibility Study in South Asian Communities
This project created a curriculum by and for South Asian community members through training a group of Community Peer Educators, who in turn created a health care provider training curriculum for the South Asian community.
Co-Investigator: Singh, Vijay

04/01/2010-10/01/2011
IRWG, University of Michigan Institute for Research on Women and Gender
Tolman, Richard (PI)
Meaning and Impact of Prenatal Ultrasound for First-Time Fathers: Effects on Paternal-Fetal Attachment, Motivation to Parent, and Positive Support towards their Partners
This study consisted of interviews with fathers directly after attending their partner's prenatal ultrasound appointment. This study assessed men's engagement with their partner, future child, and the health system.
Co-Investigator: Singh, Vijay

09/10/2010-07/31/2011
RWJF, Robert Wood Johnson Foundation Health and Society Scholars Program at the University of Michigan
Tolman, Richard (PI)
First-time Fathers Prenatal Attachment, Motivation to Parent and Partner, and Their Pregnant Partners Perceived Support
This study surveyed nearly 140 couples across pregnancy and early post-partum to assess attachment between parents and future child, motivations for parenting and partnering, and partner support.
Co-Investigator: Singh, Vijay

02/09/2009-01/31/2010
STFM, Society of Teachers of Family Medicine Foundation
Cronholm, Peter (PI)
Current trends in medical education in identifying and treating patients exposed to domestic violence
This project consisted of family medicine residency program surveys on the extent and characteristics of domestic violence training.
Co-Investigator: Singh, Vijay

9/30/2013 – 6/30/2018
5 R01 DA035811-03, NIH - DHHS
Zimmerman, Marc (PI)
Intergenerational transmission of drug use in an urban sample
Co-Investigator: Goldstick, Jason

Medical Education

August 2016 – August 2018
CRLT – Center for Research on Learning & Teaching

Daniel, Michelle (PI)
Faculty Development in Critical Reflection

The purpose of this project is to increase faculty capacity in designing, giving feedback on, and evaluating student reflections in the health professions. The project proposes an interprofessional Train-the-Trainer Faculty Development Program that supports faculty capacity for nurturing reflective practice and critical reflection. Specifically, we aim to train faculty to:

  1. Develop quality reflective questions that generate learning by engaging higher order reasoning;
  2. Engage in didactic and interactive learning that explores the concept of fostering critical reflection in health care education and practice;
  3. Articulate the personal and professional benefits of reflective practice; and
  4. Apply formal analytic frameworks to enhance the educational value of feedback to students’ reflective submissions, that is,construct meaningful feedback that deepens learning.

Co-Investigators: House, Joseph; Santen, Sally

Pediatric Emergency Care Applied Research Network (PECARN)

01/01/2015-12/31/2020
U01-NS-088034, NIH-NINDS
Silbergleit, Robert (PI)
Established Status Epilepticus Trial (ESETT)
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years. There are three active treatment arms being compared: fosphenytoin (FOS), levetiracetam (LEV), and valproic acid (VPA).

 

08/21/2015 – 04/30/2020
1R01HD085233, NICHD

Mahajan, Prashant (PI)/ Rogers, Alexander (Site PI)
RNA Biosignatures: A Paradigm Change for the Management of Young Febrile Infants

The long-term objective of our research is to investigate whole genome RNA expression profiles to define RNA biosignatures that allow precise diagnosis of isolated bacterial infections, isolated viral infections and bacterial-viral co-infections in febrile infants 60 days of age and younger.

09/01/2015-08/31/2019
1-U03 MC 28844 01-00, HRSA/MCHB/EMSC Cooperative Agreement Network Grant
Stanley, RM (PI)/ Rogers, Alexander (HEDA-PI)/ Mahajan, Prashant (Site PI)
Great Lakes Emergency Medical Services for Children Research Network
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments. 

12/2013 - 11/2018
R01 HD07191501A1, NIH/R01
Schnadower, D (PI)/ Rogers, Alexander (Site PI)/Mahajan, Prashant (Site PI)
Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis
The overall objective of this double blind placebo RCT is to determine if LGG reduces the severity of acute gastroenteritis (AGE) episodes, compared to placebo, in children aged 3 to 48 months presenting to an emergency department (ED) with AGE. We will conduct the study in 8 US EDs, within the federally funded Pediatric Emergency Care Applied Research Network (PECARN)

08/2014 - 07/2017
U01-MH-104311-01, NIMH
King, Cheryl (PI)/ Rogers, Alexander (Site PI)
Emergency Department Screen for Teens at Risk for Suicide (ED-STARS)
The overall objective is to develop a suicide risk profile and computerized adaptive screening tool for predicting suicide attempts.  The optimal screening tool developed in this collaborative project will have the potential to be disseminated nationwide to enhance the capacity of emergency departments to identify and effectively triage youth at acute risk for suicide attempts.
Co-Investigator: Cunningham, Rebecca

01/01/2013-01/31/2016
NIJ-2012-3097, National Institute of Justice (NIJ)
Rogers, Alexander/ Jing Wen Hu (Co-PI)
Development and Validation of a New Pediatric Head Injury Assessment Tool for Possible Child Abuse Cases Considering Subject-specific Child Head Anatomy
This grant is the pilot work for part of the current application. It supports patient identification and scene investigation for pediatric falls in young children presenting to University of Michigan. Thus far approximately 100 cases have been prospectively identified at this single site. This work speaks to the feasibility of the current grant. Dr. Rogers is a Co-PI and responsible for the patient identification and accrual for the project.

12/2013 - 05/2015
R01 AA021900 
Linakis, James (PI)/ Rogers, Alexander (Site PI)
Teen Alcohol Screening in the Pediatric Emergency Care Applied Research Network (ASSESS).  The primary objective is to validate a two-question screening tool for the early detection of alcohol use and problems.  The new screen, developed by the National Institute of Alcohol Abuse and Alcoholism (NIAAA) is an empirically based screen designed to predict current and future negative consequences of alcohol use.  The study will validate the NIAAA two-question screen with 12-17 year olds in U.S. pediatric emergency departments (PED).

01/01/2013-12/31/2013
N015853-00  Venaxis, Inc. (f/k/a: AspenBio Pharma, Inc.)
Rogers, Alexander (Site PI) 
AppyScore ™ The Performance of the AppyScore ™ Test in the evaluation of possible acute appendicitis in children, adolescents and young adults presenting to the emergency department.

09/30/2010-07/31/2013
3-R01-HS-019712, AHRQ
Marcin, J (PI)/ Rogers, Alexander (Site PI and Reviewer)
Factors Associated with Quality of Care Delivered to Children in US ED
The purpose of the AHRQ study is to evaluate the validity of an implicit review instrument and apply the instrument to Pediatric Emergency care delivered in a variety of settings.

07/05/2010-05/31/2016
1-R01-HD-062477-01A1, NIH, DHHS
Mahajan, Prashant (PI)/ Rogers, Alexander (Site PI)
RNA Biosignatures in the Emergency Evaluation of Febrile Infants  
Eunice Kennedy Shriver National Institute of Child Health & Human Development

The main aim of this study is to evaluate the application of diagnostic biosignatures that will allow accurate discrimination between young febrile infants evaluated in the ED with bacterial infections and those infected with non-bacterial pathogens. The long term goal is to provide the clinician with a tool that can be used in the ED setting and reduce the need for unnecessary invasive procedures, empiric antibiotics and hospitalizations.

Sepsis and Medical Device-related Infection

09/2014-08/2018
NIGMS R01 GM08170
Solomon (PI)
Biomechanics of bloodstream infection 
Our aims are: (1) Establish for biofilms the mechanical and antibiotic response to supraphysiologic elevations in temperature. (2) Using microrheology and light scattering methods, explore the mechanical implications of interactions between biofilm and host constituents. (3) Demonstrate in a rabbit model the impact of temperature-based catheter salvage.
Co-Investigator: VanEpps, Scott

07/2013-06/2015
SAEM Fellowship
VanEpps, Scott (PI)
Exotic Engineered Surfaces for Preventing Medical Device Infection
Here we ask the specific question, can functionalized carbon nanotube surfaces reduce bacterial adhesion compared to current central venous catheter materials?  We have developed a custom flow cell apparatus with high-speed epifluorescent microvideography to evaluate two key processes in surface contamination (i.e., deposition efficiency and residence time). 

04/2014-03/2015
CVC Micro Grant
VanEpps, Scott (PI) 
Microfluidic Emulation of Perivalvular Flow Regimes
The goal of this project is to design and construct an experimental system that: (1) Reproduces the wide range of microfluidic environments found around the aortic valve; (2) Allows for real-time visualization of particle deposition (i.e. platelets, bacteria); (3)  Is capable of evaluating multiple surface materials including novel antibacterial surfaces, nitric oxide releasing surfaces, and endothelial cell monolayers.

09/2014-02/2015
MCIRCC Grand Challenge
VanEpps, Scott (Co-PI)
Chiroplasmonic Nanorod-PCR for rapid determination of bacteremia and antibiotic resistance in sepsis
Our goal is to use an ultrasensistive chiroplasmonic PCR detection based on gold nanorods (NR) to reduce the time to pathogen ID and antibiotic resistance profile to <3hrs.

07/01/2012-06/30/2013
EMF/EMRA Resident Research
VanEpps, Scott (PI)
Physics of Central Line Infection
The goal of this research effort was to provide a more detailed understanding of the initial events in the development of device-related bloodstream infections.  Specifically we explored two questions: (1) How does wall shear stress modulate bacterial adhesion?  (2) Do pathogenic strains of bacteria have enhanced adhesion when compared to commensal strains

Stroke/Neurology

09/2010-08/2015
5U01NS073476-03, National Institutes of Health
Barsan, William (PI)
Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design
The use of adaptive trial designs for confirmatory phase clinical trials has the prospect for accelerating the process of drug and device acceptance and regulatory approval.  Four adaptive clinical trials will be designed for potential use in the NETT.  The project will evaluate the process and potential barriers to use of adaptive designs for confirmatory phase clinical trials.
Co-Investigators: Meurer, William; Silbergleit, Robert

01/01/2015-12/31/2020
U01-NS-088034, NIH-NINDS
Silbergleit, Robert (PI)
Established Status Epilepticus Trial (ESETT)
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years. There are three active treatment arms being compared: fosphenytoin (FOS), levetiracetam (LEV), and valproic acid (VPA).

09/30/2014-02/29/2020
U01 NS088034-01, National Institute of Neurological Disorders and Stroke (NINDS)
Kapur, Jaideep/ Silbergleit, Robert (Co-PI)
Established Status Epilepticus Treatment Trial (ESETT)

9/16/2014-8/31/2019
1U01DC013778-01A1, NIH/NIDCD
Newman-Toker (PI)
Acute Video-oculovideography for Vertigo in Emergency Rooms for Rapid Triage (AVERT)
In this project, subjects with dizziness who present to an Emergency Department (ED) will be recruited. Data will be collected from enrolled subjects including demographics, history of present illness, past medical history, medications, social history, and bedside examination items relevant to the study objectives. In particular, subjects will undergo oculomotor data collection using a video-oculovideography (VOG) recording device.
Co-Investigator: Meurer, William

4/01/2014 –3/31/2019
R25 NS08824801, NIH/NINDS
Meurer, William (PI)  
The project supports development pre-conference webinars, a 3-day in-person conference, with post conference webinars and other activities in an integrated, longitudinal, small group experience. An advanced track in clinical trial simulation and flexible adaptive design is planned for the later years that allows investigators to evaluate progress on specific outcome measures (such as number of grants funded) and internal performance metrics (knowledge and competency in clinical trial planning and conduct within course participants.

4/01/2014-3/31/2019
R18 HS02225, NIH
Kerber (PI)
The current project aims to develop an intervention for the diagnosis and treatment of BPPV from the patient's perspective and then to demonstrate that it has appropriate discriminatory characteristics, that patient’s using the intervention can perform the positional movements accurately, and that a representative sample of the US population scores measures of behavioral intent favorable to its use. Rigorous methods, incorporating quantitative and qualitative data collection and analysis, will be used to develop the intervention and demonstrate its potential value. These are critical first steps toward our long-term goal to improve the outcomes of patients with BPPV and simultaneously reduce healthcare inefficiencies. For this project, an outstanding trans-disciplinary team has been assembled including expertise in neurology, otolaryngology, physical therapy, patient decision aids, and video production.
Co-Investigator: Meurer, William

04/01/2014-03/01/2019
1R25NS088248-01, National Institutes of Health
Meurer, William (PI)
Enhancing Scientific Inquiry in Clinical Neurosciences Through Methodology Training, Mentorship, and Trans-Institutional Cooperation
Co-Investigator: Silbergleit, Robert

09/30/2013-07/31/2018
U10 NS086526-01, National Institute of Neurological Disorders and Stroke (NINDS)
Scott, Phillip (PI)
University of Michigan Regional Coordinating Stroke Center

8/01/2013 – 7/31/2018
R01 DC012760, NIH
Kerber (PI) 
Implementation of Evidence-Based Practice for Benign Paroxysmal Positional Vertigo
Benign Paroxysmal Positional Vertigo is common and causes disabling symptoms. Guideline-supported evidence-based practices exist, but are substantially underutilized. This project aims to implement these processes in a real world care setting, which has the potential to simultaneously improve patient outcomes and healthcare efficiencies
Co-Investigator: Meurer, William

8/01/2011 – 7/31/2018
U01 NS069498, NIH/NINDS
Johnston, K. (PI)
Stroke Hyperglycemia Insulin Network Effort (SHINE)
Serve as the Clinical Coordinating Center for a multicenter, prospective, randomized, controlled trial, with blinded outcomes aims to determine the efficacy and provide further safety data on the use of insulin infusion therapy for glucose control in hyperglycemic acute ischemic stroke patients. The primary outcome to be assessed at 90 days will be the difference in favorable outcome measured by the modified Rankin Scale score in the insulin infusion group compared to the control group. 
Co-Investigators: Meurer, William; Barsan, William; Sozener, Cemal

10/2013-07/2015
1U01NS062091
Qureshi (PI)
Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH)-II: A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage.

ATACH-II is a multicenter, randomized, concurrently-controlled, parallel arms design to determine the therapeutic benefit of intensive SBP treatment (SBP<140 mmHg) compared with standard SBP treatment (SBP<180 mmHg) in reducing the proportion of patients with death and disability (mRS of 4-6) at Day 90 among subjects with ICH treated within 4.5 hours of symptom onset.  Dr. Barsan, in collaboration with Dr. Quresh, will oversee the Clinical Coordination for the US sites participating in this trial.
Co-Investigator: Barsan, William

02/2013-01/2015
U01 NS 079077
Gentile (PI)
Serve as the PI for the Clinical Coordinating Center for the multicenter Insights on Selected Procoagulation Markers and Outcomes in Stroke Trial (I-SPOT) trial.  Compare the effects of strict hyperglycemia control with standard treatment of hyperglycemia on membrane-bound TF-PCA and markers of blood coagulation in T2DM patients after AIS.
Co-Investigator: Barsan, William

09/2010-08/2015
5U01NS073476-03, National Institutes of Health
Barsan, William (PI)
Accelerating Drug and Device Evaluation through Innovative Clinical Trial Design
The use of adaptive trial designs for confirmatory phase clinical trials has the prospect for accelerating the process of drug and device acceptance and regulatory approval.  Four adaptive clinical trials will be designed for potential use in the NETT.  The project will evaluate the process and potential barriers to use of adaptive designs for confirmatory phase clinical trials.
Co-Investigators: Meurer, William; Silbergleit, Robert

09/2009-08/2015
1U01NS062835
Johnston (PI)
POINT: Platelet-Oriented Inhibition in New TIA
The Primary Specific Aim of this randomized, double-blind, multicenter clinical trial is to determine whether clopidogrel (Plavix) 75 mg/day by mouth after a loading dose of 600 mg is effective in reducing the 90-day risk of major ischemic vascular events (ischemic stroke, myocardial infarction, and ischemic vascular death) when initiated within 12 hours of TIA onset in patients receiving aspirin 50-325 mg/day.
Co-Investigator: Barsan, William

07/2009-06/2015
1U01NS062778, National Institutes of Health
Wright (PI)
Progesterone for Traumatic Brain Injury: Experimental Clinical Treatment
Progesterone is a steroid found to have neuroprotective properties in multiple different animal models of brain injury.  The ProTECT trial will determine the efficacy and confirm safety of this treatment in adults with moderate to severe TBI.
Co-Investigator: Barsan, William; Silbergleit, Robert

10/2009 – 10/2013
R01 NS050372-01A1, NIH – NINDS

Scott, Phillip (PI)
Increasing Stroke Treatment through Interventional behavior change Tactics Trial (INSTINCT)
As an investigator, I studied emergency department and hospital level barriers to acute stroke treatment and the effect of education and interventions on improving treatment of acute ischemic stroke in community hospitals. Additional areas of study within this trial included stroke economics and capturing the societal economic advantage of tPA use.

9/30/2009 – 8/31/2013
R18HS017690 
Kerber (PI)  
Solutions for Vertigo Presentations In The Emergency Department (Solve) Project
The ultimate goal of this work is to optimize value and safety in healthcare through research that will support physician decision-making. A clinical decision rule for acute dizziness presentations - developed as the result of the proposed demonstration research - could improve the quality, safety, efficiency, and effectiveness of healthcare.
Co-Investigator: Meurer, Robert

5/1/2011- 5/1/2013
UL1 RR024986, MICHR CTSA
Shanley/ Meurer, William (Co-PI)
Adrenergic Blockade after Subarachnoid Hemorrhage Trial
This is a pilot clinical trial investigating the ability of acute adrenergic blockade to protect the myocardium from injury following aneurysmal subarachnoid hemorrhage (aSAH). Planned enrollment is twenty patients. In addition, the relationship between aSAH, the heart, outcomes, and the sympathetic nervous system will be explored in greater detail in humans, expanding existing knowledge on this topic.
Role: Principal Investigator

8/1/2008-1/1/2013
P50 NS044283
Pancioli (PI)/ Meurer, William (Site-PI)
The Combined Approach to Lysis Utilizing Eptifibatide and rt-PA in Acute Ischemic Stroke–Enhanced Regimen (CLEAR-ER Trial)
The CLEAR-ER trial is an NIH funded, multicenter, randomized, double-blind trial to determine the safety of the combination of low dose rt-PA (0.6 mg/kg total) plus eptifibatide (bolus 135 mcg/kg and 2 hour infusion at 0.75 mcg/kg/min) compared to standard dose rt-PA (0.9 mg/kg) in patients with acute ischemic stroke that can have the rt-PA initiated within 3 hours of symptom onset.

08/01/2005-04/30/2012
R01 NS050372-05, National Institute of Neurological Disorders and Stroke (NINDS)
SCOTT, PHILLIP (PI)

08/2006-07/2011
1 U01 NS056975, NIH/NINDS  
Rapid Anticonvulsant Medications Prior to Arrival Trial (RAMPART)
The goal of  RAMPART is to study will determine if the anti-seizure drug midazolam given via IM stops seizures as well as the anti-seizure medicine lorazepam given IV, and if there is a difference in the rapidity and safety of these two medicines given in these different ways.
Co-Investigator: Barsan, William