June 8, 2018

NCI Statement on Cervical Cancer Prevention Draws on Leadership from Family Medicine Faculty

The nation’s top cancer organizations have issued a statement urging increased HPV vaccination and screening to reduce cervical cancer, with contributions from Diane M. Harper, professor and physician director for community outreach and engagement at the University of Michigan Rogel Cancer Center.


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Nicole Fawcett, Michigan Health, June 7, 2018

A two-step process can prevent cervical cancer and reduce the likelihood of several other HPV-associated cancers as well.

Step 1: Get screened.

Step 2: Get vaccinated.

“Screening detects early changes before cervical cancer can develop, and the HPV vaccine helps keep your screen results normal,” says Diane Harper, M.D., MPH, M.S., professor and physician director for community outreach and engagement at the University of Michigan Rogel Cancer Center. Harper has authored over 200 articles in her career as a clinical researcher of HPV-associated diseases, their prevention, early detection, and treatment for the prevention of cancer, with over 15,000 combined citations.

Harper and her peers want to share the simple two-step prevention message. This week, all 70 National Cancer Institute-designated cancer centers, along with a half-dozen cancer advocacy groups, issued a joint statement urging increased HPV vaccination and screening for HPV-related cancers, especially cervical cancer.

Cervical cancer affects 7 of 100,000 women in the United States —a modest rate compared to many cancers but still significant. About 13,250 American women will be diagnosed with cervical cancer this year, and 4,100 will die from it.

Prevention efforts pay off

Combined with regular screens for cervical cancer, the HPV vaccine may lower the incidence even more. 

HPV, or human papillomavirus, is a sexually transmitted infection that is spread by skin-to-skin contact. HPV infection causes almost all cervical cancers. It is also a major contributor to other genital cancers, anal cancer, and head and neck cancer.

HPV vaccines were introduced in 2006, but uptake has been modest. About half of girls and 38 percent of boys have completed the series of three HPV vaccine shots.

Diane Harper, MD
Diane Harper, M.D., M.P.H., M.S., Professor

“I strongly believe in cervical cancer prevention and the effects of the HPV vaccine,” Harper says. “The vaccines will give you a higher chance of a normal screening.”

But, she points out, screening is what provides the bulk of prevention over a woman’s lifetime.

Which is why Harper tells her patients that the best gift they can give their daughter for her 21st birthday is an introduction to the concept that cervical cancer screening prevents cancer. The test can detect early changes in the cervix before cancer develops, when it’s easier to treat.

When the Pap test was introduced, cervical cancer affected 50 of 100,000 women annually; over the past 70 years, rates of cervical cancer have dropped sevenfold.

A 'Gender-Neutral' Vaccine

The joint statement of NCI-designated cancer centers notes the "gender neutral" scope of HPV vaccinations, and the coalition's call to action emphasizes a goal to vaccinate more than 80 percent of males and females ages 13 to 15 by 2020. 

Studies show that young adults want their sexual partners to be vaccinated. Harper and her colleagues conducted a 2012 survey with college-aged women and found that young women strongly preferred their male partners to be vaccinated for HPV. A recent follow-up study in 2018 found that their college-aged male counterparts demonstrated an even stronger preference for HPV vaccination for their female partners. Overall, the young adults in the study who were vaccinated strongly preferred their partners to be also, compared to the preference of those who were not vaccinated. The two studies were published in the journals PLOS One and Papillomavirus Research respectively.

The two studies were conducted with data from undergraduate students at a metropolitan research university in Kentucky. "College age recruitment for vaccination may result in a higher vaccination rate," Harper suggestions.

Recommended screening and vaccine guidelines

Cervical cancer screening with a Pap test is recommended to begin at age 21 and recur every three years if no abnormalities are found. At 30, women can be screened every five years if no abnormalities are found.

The HPV vaccine is offered for girls and boys. The CDC recommends completing the vaccine series between ages 9 and 13; two or three doses are needed, depending on a child’s age. Harper notes that the doses can be spaced a year apart at this age, making it easier to complete the two or three necessary doses.

Those who miss the early window, though, can still get covered. The vaccine is approved for men and women up to age 26. After age 13, all three doses should be administered within six months.

Because HPV is sexually passed back and forth, boys and girls could both get vaccinated.

Potential for greater impact

“This vaccine provides important protection for some people,” says Harper, who was involved in much of the research on HPV vaccines over the past 15 years. But she notes that there are more opportunities to have an impact.

While cervical cancer most often occurs in women ages 35 to 44, there is another uptick of diagnoses in women over age 65. Many 40- to 50-year-old women are going through divorce and engaging in sexual activity with new partners, Harper notes.

“The #MeToo movement highlights that sexual activity occurs between males and females of all ages, willingly and unwillingly,” she says. “The HPV vaccines can potentially protect these women as well, even though it will be an off-label use for this age.”

Meanwhile, researchers are looking at ways to make cervical cancer screening easier, such as self-collection using a tampon-like kit at home. This would make screening more available to women who have religious, economic or other access barriers.

Researchers are also working to develop a therapeutic vaccine to fire up the immune system against existing HPV infection. They hope to couple it with the preventive vaccine to eliminate infection now and in the future.


Articles Cited

Harper DM, Alexander NM, Ahern DA, et al. Women Have a Preference for Their Male Partner to Be HPV Vaccinated. PLoS ONE. 2014;9(5). doi: 10.1371/journal.pone.0097119.

Lajoie AS, Kerr JC, Clover RD, Harper DM. Influencers and preference predictors of HPV Vaccine Uptake among US Male and Female Young Adult College Students. Papillomavirus Research. March 2018. doi:10.1016/j.pvr.2018.03.007 

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