AASLD 2018

A daily compilation of the main sessions during which our faculty, fellows, and researchers are presenting at The Liver Meeting® 2018, November 9–13, 2018, in San Francisco, California.

Awards

Jad Baki
AASLD Foundation Abstract Award – Student Research Award
The award is given to a graduate or undergraduate student (i.e., has not received an MD, PhD, or equivalent doctoral degree) and is the primary contributor to the research. The award is to cover expenses related to attending the conference.

Monica Konerman, MD, MSc
AASLD Foundation Research Award – Alan Hofmann Clinical and Translational Research Award in Liver Diseases
Project Title: Optimizing lifestyle interventions as curative therapy for non-alcoholic fatty liver disease
Mentor: Anna S. Lok, MD, FAASLD

Amoah Yeboah-Korang, MD, MPH
AASLD Foundation 
Career Development Award – Advanced/Transplant Hepatology Fellowship
Project Title: Identification of drug-induced liver injury from the electronic medical record using natural language processing and ICD-10 codes
Mentor: Robert J. Fontana, MD, FAASLD

Chairs, Moderators, Panelists

Friday, November 9, 2018

Clinical Research Workshop: Researching and Applying Precision Medicine in Hepatology
Moscone Center, Room 154/156
9:00 AM – 11:00 AM
Chairs: Robert Fontana, Julia Wattacheril
Panelists: Louise Bier, David Goldstein, Yujin Hoshida, Nancy Spinner, Grace Su, Julia Wattacheril

Breakout Sessions I, II, and III
11:00 AM – 12:00 PM
Chairs: Robert Fontana, Julia Wattacheril

Saturday, November 10, 2018

SIG Program: Combined Organ Transplants
Moscone Center, Room 157/160
9:00 AM – 3:30 PM
Chairs: James Trotter, John Magee, Timucin Taner

Sunday, November 11, 2018

Transplant Plenary I
Moscone Center, Hall D
8:00 AM – 9:30 AM
Moderators: Kimberly Brown, John Magee

Parallel 16: Liver Transplantation: Optimizing the Recipient
Moscone Center, Room 153/155
2:00 PM – 3:30 PM
Moderators: Edward Doo, Pratima Sharma

Parallel 17: Healthcare Delivery, Access, and Quality
Moscone Center, Room 306/308
2:00 PM - 3:30 PM
Moderators: Elliot Tapper, Fasiha Kanwal

Special Interest Groups (SIG) Programs

Friday, November 9, 2018

The Challenge of Fontan-Associated Liver Disease
Moscone Center, Room 214/216
9:20 AM
The transplant option–decision making
John Magee

Advances in Genetics and Epigenetics in NAFLD: From Pathogenesis to Personalized Medicine
Moscone Center, Room 24/25
2:05 PM
Insights into disease pathogenesis from population genetic studies
Elizabeth Speliotes

Herbal and Dietary Supplement Induced Liver Injury: Defining the Future
Moscone Center, Room 153/155
2:40 PM
Case presentation
Robert Fontana

Saturday, November 10, 2018

Combined Organ Transplants
Moscone Center, Room 157/160
10:25 AM
Indications, patient selection and allocation policy
Pratima Sharma

Sunday, November 11, 2018

HBV Flares: Distinguishing the Good From the Bad
Moscone Center, Room 157/160
9:15 AM
Reactivation flares
Anna Lok

Alcoholic Liver Disease: Policy and Practice
Moscone Center, Room 206/208
10:35 AM
Epidemiology of AUD and ALD
Jessica Mellinger

Workshops, Courses

Friday, November 9, 2018

Clinical Research Workshop: Researching and Applying Precision Medicine in Hepatology
Moscone Center, Room 154/156
9:45 am
Applying precision medicine in imaging of liver disease
Grace Su

Clinical Research Workshop: Breakout Session III
Moscone Center, Room 154/156
11:00 am
Methodological consideration in genomics
Elizabeth Speliotes, Saul Karpan

Sunday, November 11, 2018

Hepatology Associates Course
Moscone Center, Room 153/155
11:05 am
Non-conventional approaches to management of liver disease
Robert Fontana

Monday, November 12, 2018

EMW 42 – Early Morning Workshop (Clinical)
Refer to workshop ticket for room location
6:30 AM – 7:30 AM
Management pearls in acute liver failure
Robert Fontana, Norman Sussman

EMW 44 – Early Morning Workshop (Clinical)
Refer to workshop ticket for room location
6:30 AM – 7:30 AM
Managing acute and chronic liver disease during pregnancy
Monika Sarkar, Grace Su

Abstracts – Oral Presentations

Sunday, November 11, 2018

Parallel 2: Drug-induced Liver Injury
Moscone Center, Room 206/208
8:30 am
Abstract 0038
Identification of a PTPN22 missense variant as a general genetic risk factor for drug-induced liver injury
Paul Watkins, Elizabeth Cirulli, Karen Abramson, Raul Andrade, Einar Bjornsson, Naga Chalasani, Robert Fontana, Par Hallberg, Yi-Ju Li, Maribel Lucena, Nanye Long, Miriam Molokhia, Mathew Nelson, Joseph Odin, Munir Pirmohamed, Thorunn Rafnar, Jose Serrano, Karen Stefansson, Andrew Stolz, Ann Daly, Guruprasad Aithal

Parallel 9: Metabolic and Genetic Liver Disease
Moscone Center, Room 214/216
11:00 AM
Abstract 0081
Outcomes of WTX101 treatment in a phase 2 and extension study in Wilson disease: Comparison of patients with and without cirrhosis
Michael Schilsky, Frederick Askari, Anna Czlonkowska, Peter Ferenci, Aftab Ala, Danny Bega, Jeffrey Bronstein, David Nicholl, Karl Heinz Weiss

Parallel 11: Hepatobiliary Cancer Risks
Moscone Center, Room 306/308
10:45 AM
Abstract 0092
Direct-acting antiviral therapy significantly reduces early HCC recurrence: A multicenter U.S. cohort study
Amit Singal, Neil Mehta, Nicole Rich, Caitlin Murphy, Andrea Branch, Anjana Pillai, Maarouf Hoteit, Michael Volk, Mobolaji Odewole, Steven Scaglione, Jennifer Guy, Adnan Said, Jordan Feld, Binu John, Catherine Frenette, Parvez Mantry, Amol Rangnekar, Omobonike Oloruntoba, Michael Leise, Janice Jou, Kalyan Ram Bhamidimarri, Laura Kulik, Tram Tran, Hrishikesh Samant, Renumathy Dhanasekaran, Andres Duarte-Rojo, Reena Salgia, Sheila Eswaran, Apurva Modi, Avegail Flores, Sanjaya Satapathy, Robert Wong, Annsa Huang, Suresh Misra, Myron Schwartz, Robert Mitrani, Chanda Ho, Suraj Sharma, Venkata Konjeti, Alexander Dao, Kevin Nelson, Matthew Gulau, Kelly Delarosa, Usman Rahim, Meher Mavuram, Jesse Xie, Neehar Parikh

Parallel 16: Liver Transplantation: Optimizing the Recipient
Moscone Center, Room 153/155
3:00 pm
Abstract 0125
Renal-sparing immunosuppression at time of transplant does not improve post-transplant renal outcomes
Pratima Sharma, Yihan Sun, Joslyn Neal, Jennifer Erley, James Shen, Sarah Tischer, Christopher Sonnenday, Jeong Park

Parallel 18: Pediatric Cholestasis – Basic and Clinical
Moscone Center, Room 312/314
2:45 PM
Abstract 0136
Neurocognitive outcomes in older children with biliary atresia and native liver: Results from the Childhood Liver Disease Research Network (ChiLDReN) Study
James Squires, Lisa Sorensen, Emily Fredericks, Vicky Ng, Kieran Hawthorne, Lisa Henn, Karen Murray, Kathleen Loomes, Saul Karpen, Laurel Cavallo, Jean Molleston, Jorge Bezerra, Philip Rosenthal, Robert Squires, Kasper Wang, Kathleen Schwarz, Stephen Guthery, Binita Kamath, Estella Alonso, John Magee, Ronald Sokol, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 18: Pediatric Cholestasis – Basic and Clinical
Moscone Center, Room 312/314
3:00 PM
Abstract 0137
Prognostic value of serum bile acids after Kasai portoenterostomy in biliary atresia
Sanjiv Harpavat, James Heubi, Saul Karpen, Vicky Ng, Kenneth Setchell, Benjamin Shneider, Estella Alonso, Jorge Bezerra, Stephen Guthery, Kathleen Loomes, John Magee, Jean Molleston, Karen Murray, Philip Rosenthal, Averell Sherker, Robert Squires, Kasper Wang, Ronald Sokol, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 20: Ongoing Benefits of HCV Therapy
Moscone Center, Room 157/160
5:30 PM
Abstract 0149
Improvements in symptoms shortly following viral cure for chronic hepatitis C: A large multi-site clinical cohort study
Donna Evon Paul Stewart, Jipcy Amador, Nancy Reau, Souvik Sarkar, Rajender Reddy, Bryce Reeve, Anna Lok, Richard Sterling, Carol Golin, Marina Serper, Joseph Lim, Adrian Di Bisceglie, Michael Fried, David Nelson

Parallel 24: Genomics Link to Disease Phenotypes
Moscone Center, Room 22/23
5:45 pm
Abstract 0174
Plasma glycoprotein profile in liver transplant recipients reveals enrichment of inflammatory proteins with advancing chronic kidney disease
Pratima Sharma, Pradeep Kayampilly, Venkat Basrur, Raji Menon, Hellan Kwon, Subramaniam Pennathur

Parallel 25: Health Economics and Patient Centered Outcomes
Moscone Center, Room 306/308
5:00 PM
Abstract 0177 - AASLD Foundation Abstract Award - Student Research Award
Frailty and opiate use are strongly correlated with quality of life in patients with cirrhosis: A prospective study of 300 outpatients without hepatic encephalopathy
Jad Baki, Jane Wong, Neehar Parikh, Anna Lok, Elliot Tapper

Monday, November 12, 2018

Presidential Plenary – Clinical Science
Moscone Center, Hall D
8:30 AM
Abstract 0015
Predictors of outcome in children with biliary atresia surviving with native liver at two years of age
Veena Venkat, Vicky Ng, John Magee, Wen Ye, Kieran Hawthorne, Sanjiv Harpavat, Karen Murray, Kasper Wang, Jean Molleston, Henry Lin, Lee Bass, Nisreen Soufi, Cara Mack, Jorge Bezerra, Stephen Guthery, Averell Sherker, Philip Rosenthal, Ronald Sokol, Saul Karpen, Childhood Liver Disease Research Network (ChiLDReN)

Parallel 32: Complications of Cirrhosis III
Moscone Center, Room 206/208
11:15 AM
Abstract 0220
Incidence and predictors of hepatic encephalopathy in a population-based cohort of older Americans with cirrhosis: Role of opiates, benzodiazepines and proton-pump inhibitors (PPIs)
Elliot Tapper, James Henderson, Jad Baki, Neehar Parikh, Anna Lok

Parallel 33: HCV Therapy in Unique Populations
Moscone Center, Room 154/156
11:15 am
Abstract 0226
High efficacy of glecaprevir/pibrentasvir in patients with chronic HCV GT1 infection who failed prior treatment with NS5A-inhibitor plus sofosbuvir regimens
Mark Sulkowski, Anna Lok, Ira Willner, Rajender Reddy, Mitchell Shiffman, Mohamed Hassan, Brian Pearlman, Federico Hinestrosa, Ira Jacobson, Giuseppe Morelli, Joy Peter, Monika Vainorius, Larry Michael, Michael Fried, Gary Wang, Yiran Hu, Jens Kort, David Nelson

Abstracts – Poster Presentations

Moscone Center, Hall C – Poster Hall

Friday, November 9, 2018: 8:00 AM – 5:30 PM

Drug Metabolism and Toxicity
Abstract 0334
Asparaginase-induced hepatotoxicity
Natasha Kamal, Niharika Samala, Christopher Koh, Robert Fontana, Andrew Stolz, Francisco Durazo, Paul Hayashi, Jay Hoofnagle

Health Care Delivery, Access, and Quality
Abstract 0461
Women with cirrhosis are at increased risk of hospitalization compared to men
Jessica Rubin, Marie Sinclair, Robert Rahimi, Elliot Tapper, Jennifer Lai

Health Care Delivery, Access, and Quality
Abstract 0477
Advanced care planning in end stage liver disease: opportunity for improvement
Meaghan Trainor, Tammy Ellies, Pratima Sharma

Health Care Delivery, Access, and Quality
Abstract 0518
Opioid and benzodiazepine use in alcoholic cirrhosis patients is common and associated with increased hospital admissions
Jessica Mellinger, Gerald Winder, Kerby Shedden, Anne Fernandez, Allison Lin, Michael Volk, Frederic Blow, Anna Lok

Hepatitis C Therapeutics: Approved Agents
Abstract 0612
Patient-reported symptom experiences are heterogeneous during direct acting antiviral therapy for chronic hepatitis C: A prospective real-world cohort study
Souvik Sarkar, Donna Evon, Jipcy Amador, Paul Stewart, Anna Lok, Richard Sterling, Bryce Reeve, Marina Serper, Rajender Reddy, Nancy Reau, Joseph Lim, Carol Golin, David Nelson, Adrian Di Bisceglie, Michael Fried

Hepatitis C Therapeutics: Approved Agents
Abstract 0653
Efficacy and safety of 8 weeks of glecaprevir/pibrentasvir in treatment-naïve adults with HCV genotype 1–6 and aspartate aminotransferase to platelet ratio index (APRI) ≤1
Robert Fontana, Sabela Lens, Stuart McPherson, Magdy Elkhashab, Krum Katzarov, Ana Gabriela Pires, Zhenyi Xue, Roger Trinh, Lino Rodrigues Jr., Ariel Porcalla, Stefan Zeuzem

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0716
The role of HEV infection in U.S. patients with suspected drug induced liver injury
Robert Fontana, Paul Hayashi, Jay Hoofnagle, Huiman Barnhart, Ronald Engle, Patrizia Farci

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0721
Liver injury during pembrolizumab immunotherapy is associated with a lower rate of tumor remission and higher rate of mortality
Russell Dolan, Irene Tsung, Leslie Fecher, Christopher Lao, Robert Fontana

Hepatotoxicity and Drug Induced Liver Injury
Abstract 0729A
Quantitation of catechin content in herbal and dietary supplements implicated in human hepatotoxicity: A preliminary report from the Drug Induced Liver Injury Network (DILIN)
Victor Navarro, Bharathi Avula, Yanhong Wang, Huiman Barnhart, Manisha Verma, Ikhlas Khan, Jawad Ahmad, Herbert Bonkovsky, Naga Chalasani, Robert Fontana, Leonard Seeff, Jose Serrano, Andrew Stolz, Drug Induced Liver Injury Network

Patient Centered Outcomes Research
Abstract 0756
Liver disease is associated with falls and fractures: A nationally-representative cohort study
Maria Camila Perez-Matos, Gordon Jiang, Elliot Tapper

Patient Centered Outcomes Research
Abstract 0758
Use of prescription opioid and benzodiazepines is two-folds higher among patients with cirrhosis compared to other forms of chronic disease
Monica Konerman, Mary Rogers, Brooke Kenney, Brahmajee Nallamothu, Amit Singal, Pratima Sharma, Elliot Tapper, Sameer Saini, Akbar Waljee

Patient Centered Outcomes Research
Abstract 0781
Awareness and knowledge of non-alcoholic fatty liver disease among office employees in Beijing, China
Wei Zhang, Samantha Chao, Stephanie Chen, Huiying Rao,  Rui Huang,  Lai Wei, Anna Lok

Saturday, November 10, 2018: 2:00 PM – 7:30 PM

Clinical and Translational Hepatobiliary Cancer I
Abstract 0904
A high proportion of hepatocellular carcinoma have indolent growth patterns
Nicole Rich, Binu John, Neehar Parikh, Christopher Hernandez, Jorge Marrero, Mobolaji Odewole, Latha Sundaram, Venkata Konjeti, Shivangi Sharma, Amit Singal

Clinical and Translational Hepatobiliary Cancer I
Abstract 0908
Cost-effectiveness of sorafenib versus selective internal radiation therapy for patients with advanced hepatocellular carcinoma
Neehar Parikh, Amit Singal, Laura Kulik, David Hutton

Complications of Cirrhosis I
Abstract 0962
Limited progress in hepatorenal syndrome (HRS) reversal and survival 2002–2016
Mary Thomson, Arthur Taylor, Pratima Sharma, Anna Lok, Elliot Tapper

Liver Transplantation: Management and Outcomes
Abstract 1205
Prevalence and patterns of prescription opioid use before and after liver transplantation
David Cron, Monica Konerman, Ali Hammoud, Jay Lee, Akbar Waljee, Chad Brummet, Jennifer Waljee, Michael Englesbe, Christopher Sonnenday

Sunday, November 11, 2018: 8:00 AM – 5:30 PM

Alcoholic Liver Disease: Clinical and Experimental
Abstract 1400
Women with alcoholic liver disease are less likely to be listed for liver transplantation
Alisa Likhitsup, Lisa McElroy, Jessica Mellinger, Naba Saeed, Ammar Hassan, Gerald Winder, Christopher Sonnenday, Robert Fontana

Alcoholic Liver Disease: Clinical and Experimental
Abstract 1401
Alcoholic liver disease has rapidly emerged as the leading indication for liver transplant evaluation
Alisa Likhitsup, Jessica Mellinger, Lisa McElroy, Naba Saeed, Ammar Hassan, Gerald Winder, Christopher Sonnenday, Robert Fontana

Cholangiocyte Biology – Poster of Distinction
Abstract 1449
HH signaling regulates extrahepatic bile duct epithelial cell proliferation after injury
Junya Shiota, Nureen Hanisah Mohamad Zaki, Juanita Merchant, Linda Samuelson, Nataliya Razumilava

Cholangiocyte Biology
Abstract 1452
An important role for Wnt signaling in cholangiocyte regeneration in extrahepatic bile ducts
Nataliya Razumilava, Junya Shiota, Nureen Hanisah Mohamad Zaki, Juanita L Merchant, Linda Samuelson

HCV Diagnostics, Epidemiology and Natural History
Abstract 1616
Prevalence and predictors of medication non-adherence in a multi-center cohort treated with hepatitis C direct-acting antivirals: Results from the Patient-Reported Outcomes Project (PROP-UP)
Marina Serper, Donna Evon, Paul Stewart, Anna Lok, Jipcy Amador, Bryce Reeve, Carol Golin, Michael Fried, Rajender Reddy, Richard Sterling, Souvik Sarkar, Adrian Di Bisceglie, Joseph Lim, David Nelson, Nancy Reau

Monday, November 12, 2018: 8:00 AM – 5:30 PM

NAFLD and NASH: Clinical II
Abstract 2271
Fat accumulation, liver damage and metabolic abnormalities in Chinese NAFLD patients with moderate/severe hepatic steatosis
Wei Zhang, Elizabeth Ann Wu, Yi Wang, Rui Huang, Sravanthi Kaza, Anqi Li, Chao Sun, Huiying Rao, Lai Wei, Grace Su, Anna Lok

NAFLD and NASH: Clinical II
Abstract 2279
The high economic burden of non-alcoholic steatohepatitis (NASH) compared to matched controls: Results from the 2016 US National Health and Wellness Survey (NHWS)
Elliot Tapper, Maria-Magdalena Balp, Nancy Krieger, Raymond Przybysz, Nate Way, Jennifer Cai, Dion Zappe, Sarah Mckenna, Garth Wall, Nico Janssens

NAFLD and NASH: Clinical II
Abstract 2280
Lifestyle modification in patients with non-alcoholic fatty liver disease: The main barrier is motivation to change, not knowledge
Lisa Glass, Jane Wong, Robert Fontana, Elliot Tapper, Michael Volk, Anna Lok, Monica Konerman

NAFLD and NASH: Clinical II
Abstract 2335
Survey of non-alcoholic fatty liver disease knowledge and nutrition and physical activity patterns among the general public in Beijing, China
Stephanie Chen, Samantha Chao, Monica Konerman, Wei Zhang, Huiying Rao, Elizabeth Ann Wu, Andrew Lin, Lai Wei, Anna Lok