Our Researchers

Douglas Arenberg, MD

Douglas Arenberg, MD, conducts research in angiogenesis, the role of migration inhibitory factor (MIF) in cancer, tumor microenvironment and its influence on tumor biology. His research also focuses on lung cancer screening, early detection and risk biomarker studies.

Publications

View all Dr. Arenberg's publications in PubMed.

Christine Freeman Basmajian, PhD

Research Assistant Professor, Department of Internal Medicine
Deputy Associate Chief of Staff - Research, VA Ann Arbor Healthcare System

Degrees and Fellowships

  • PhD, University of Michigan, 2006
  • Pulmonary and Critical Care Research Fellow, University of Michigan, 2009 

Research Interests

The long term goal of my research is to improve understanding of how the immune system contributes to Chronic Obstructive Pulmonary Disease (COPD) progression. I am particularly interested in the role of CD8+ T cells, NK cells, and NK T cells in COPD pathogenesis and providing insight into the mechanisms by which these cells could be causing lung destruction. For these studies, we use human lung tissue from clinically-indicated surgical procedures. We have developed innovative techniques that allow us to directly study the response of cytotoxic cells in vitro and correlate this to patient data.  

Publications

View all Dr. Basmajian's publications in PubMed.

Kevin Chan, MD

Kevin Chan, MD, conducts research in clinical management and outcomes in lung transplantation, infections in lung transplantation, predictors of prognosis in patients with end stage lung disease, and pulmonary hypertension.

Publications

View all Dr. Chan's publications in PubMed.

Michael Coffey, MD

Michael Coffey, MD, conducts research in the regulation of the enzyme 5-lipoxygenase in alveolar macrophages, role of obesity in the pathogenesis of asthma, and sleep disordered breathing and asthma phenotype.

Publications

View all Dr. Coffey's publications in PubMed.

Colin Cooke, MD, MSc, MS

Colin Cooke, MD, MSc, MS, conducts research in how healthcare policy, the healthcare system, and individual patient characteristics impact the quality, efficiency and outcomes of care delivered to patients in the intensive care unit.

Publications

View all Dr. Cooke's publications in PubMed.

Jeffrey Curtis, MD

Jeffrey Curtis, MD, conducts research on the regulation of pulmonary host defense and immune responses through lymphocyte recruitment and apoptosis and macrophage phagocytosis.

Publications

View all Dr. Curtis's publications in PubMed.

Robert Dickson, MD

Robert Dickson, MD, conducts research in the area of microbial communities in the respiratory tract.

Publications

View all Dr. Dickson's publications in PubMed.

John Erb-Downward, PhD

Assistant Research Scientist, Department of Internal Medicine 

Degrees and Fellowships

  • BS, Cornell University, 1996
  • PhD, Microbiology and Immunology, University of Michigan, 2005
  • Fellowship, Pulmonary & Critical Care Medicine, University of Michigan, 2009

Research Interests

Dr. Erb-Downward's investigative career has focused on the communication between host and microbe, including the microbiome. Some of my initial publications identified the ability of a pathogenic fungus, Cryptococcus neoformans, to produce immunomodulatory prostaglandins. These investigations demonstrated that through small molecules, microbes were capable of communicating directly with mammalian host cells in the same language that the host cells use to communicate with each other. This research led me to study microbial ecology and the interactions between the host and the indigenous microbiota of the lung. Broadly, my current research involves elucidating the role of the lung microbiome in lung disease through an examination of the bacterial communities present in the lungs of healthy individuals and those with lung disease (COPD, IPF, lung cancer, ALI and after lung transplantation). To characterize these bacterial communities I use culture-independent methods such as high-throughput 454 pyrosequencing of the bacterial 16S rRNA gene along with multivariate visualization and analysis tools to identify community differences. I am working with several different investigators combining microbial community data with clinical data to determine which bacterial communities drive the differences between health and disease, and which host factors correlate with community differences. 

Dr. Erb-Downward is a member of Dr. Gary Huffnagle's lab team.

Publications

View all Dr. Erb-Downward's publications in PubMed.

Kevin Flaherty, MD, MS

Kevin Flaherty, MD, MS, conducts research in pulmonary fibrosis.

Publications

View all Dr. Flaherty's publications in PubMed.

Margaret Gyetko, MD

Margaret Gyetko, MD, conducts research on the regulation of macrophage functions, genetic regulation of protease/antiprotease systems in the lung, the role of urokinase in the modulation of pulmonary inflammation, protease/cytokine interactions, and the role of the urokinase receptor in cell movement and recruitment.

Publications

View all Dr. Gyetko's publications in PubMed.

MeiLan Han, MD, MS

MeiLan Han, MD, MS, conducts research in COPD and airways diseases.

Publications

View all Dr. Han's publications in PubMed.

Jeffrey Horowitz, MD

Jeffrey Horowitz, MD, conducts research on mechanistic regulation of fibroblast survival and apoptosis by soluble and extracellular-matrix derived signaling during lung injury, repair and resolution, with a focus on how these mechanisms contribute to the pathogenesis of fibrotic lung diseases such as idiopathic pulmonary fibrosis (IPF).

Publications

View all Dr. Horowitz's publications in PubMed.

Steven Huang, MD

Steven Huang, MD, conducts research on the biology, pathology, and treatment of pulmonary fibrosis as it relates to prostaglandin E2 and other eicosanoids.

Publications

View all Dr. Huang's publications in PubMed.

Yvonne Huang, MD

Yvonne Huang, MD, conducts research on microbiome interactions in the human host that shape the pathogenesis and phenotypes of asthma and COPD seen in adult patients.

View Dr. Huang's lab website.

Publications

View all Dr. Huang's publications in PubMed.

Gary Huffnagle, PhD

Nina and Jerry D. Luptak Research Professor
Professor, Department of Internal Medicine
Professor, Department of Microbiology and Immunology
Professor, Department of Molecular, Cellular & Developmental Biology 
Associate Program Director, T32 Multidisciplinary Training Program in Lung Disease
Research Professor, Mary H. Weiser Food Allergy Center

Degrees and Fellowships

BS, Microbiology, Pennsylvania State University
PhD, Immunology, University of Texas Southwestern Medical Center, 1990
Postdoctoral Training, Immunopathology, University of Texas Southwestern Medical Center

Research Interests

Our laboratory's research interests are focused on the interaction between the microbiome and the immune system, both in control of pulmonary and intestinal inflammation and in control of infectious diseases (bacterial and fungal). Projects include the role of immune system-microbiome interactions in respiratory disease (COPD, allergy, IPF, lung inflammation) and in Clostridium difficile infection.  We utilize an interdisciplinary approach that combines research in pathophysiology, immunology, bacterial physiology and virulence, microbial ecology and microbial bioinformatics. Our translational research includes clinical sample analysis, in vitro experiments and in vivo models.

View Dr. Huffnagle's lab website.

Publications

View all Dr. Huffnagle's publications in PubMed.

Robery Hyzy, MD

Robery Hyzy, MD, conducts research in the areas of ARDS, ventilator associated pneumonia, sepsis, and delirium.

Publications

View all Dr. Hyzy's publications in PubMed.

Theodore Iwashyna, MD, PhD

Theodore Iwashyna, MD, PhD, conducts research on the organization of critical care services to provide high quality and value, medical education, and health services.

Publications

View all Dr. Iwashyna's publications in PubMed.

Venkateshwar Keshamouni, PhD

Associate Professor, Department of Internal Medicine

Degrees and Fellowships

  • PhD, University of Hyderabad, Hyderabad India, 1996
  • Postdoctoral Research Fellow, Indiana University, 1998
  • Postdoctoral Research Fellow, Wayne State University, 2002
  • Postdoctoral Research Fellow, University of Michigan, 2003

Research Interests

The dynamic interactions between cancer cells and the tumor microenvironment (TME) foster tumor growth, metastasis and may influence the outcome of a given therapy. It is apparent that understanding the unique molecular circuitry of the TME is essential for successful control of a malignancy. In spite of being the leading cause of cancer death world-wide, the nature and the role of TME in lung tumor progression and metastasis is poorly understood. Towards this goal, our efforts are focused on delineating basic mechanisms and interactions in lung TME particularly that are mediated by the cytokine TGF-beta, and to develop therapeutic strategies to disrupt these interactions. Projects that we are currently pursuing are 1) targeting TGF-beta mediated Epithelial-mesenchymal transition for prognosis and therapy of lung cancer; 2) regulation of immune evasive mechanisms in tumor microenvironment; and 3) restoring tumor suppressive functions of TGF-b.

Publications

View all Dr. Keshamouni's publications in PubMed.

Kevin Kim, MD

Kevin Kim, MD, conducts research in tissue fibrosis and type I collagen affect on pathology in fibrosis and cancer.

Publications

View all Dr. Kim's publications in PubMed.

Vibha Lama, MD, MS

Vibha Lama, MD, MS, conducts research on the pathogenesis and treatment of bronchiolitis obliterans, role of prostaglandins in fibroproliferation, and exercise in interstitial lung disease.

Publications

View all Dr. Lama's publications in PubMed.

Fernando Martinez, MD, MS

Fernando Martinez, MD, MS, conducts research in chronic obstructive pulmonary disease (COPD), interstitial lung disease, lung transplantation, and lung volume reduction.

Publications

View all Dr. Martinez's publications in PubMed.

Bethany Moore, PhD

Galen B. Toews MD Collegiate Professor of Pulmonary and Critical Care Medicine
Professor, Department of Internal Medicine
Professor, Department of Microbiology and Immunology
Director, Doctoral Program in Immunology, Rackham Graduate School

Degrees and Fellowships

  • BA, Microbiology, University of Texas, 1986
  • PhD, University of Texas Southwestern Medical Center, 1992
  • Fellowship, Rheumatology, University of Texas Southwestern Medical Center, 1994
  • Fellowship, Biology, Stanford University School of Medicine, 1995
  • Fellowship, Immunology, Stanford University School of Medicine, 1997

Research Interests

Dr. Moore's laboratory has two basic areas of interest. The first is the pathogenesis of fibrotic lung disease. The second is pulmonary host defense following bone marrow transplantation (BMT). Specific interests in these areas are as follows:

Fibrotic Lung Disease:

  • The role of chemokines and eicosanoids in the pathogenesis of experimental fibrosis
  • The role of circulating fibrocytes in the pathogenesis of fibrosis
  • The role of viral infections in the exacerbation of experimental fibrosis
  • Epithelial/fibroblast interactions in fibrosis
  • Viral-induced fibrosis in the aged lung

View Dr. Moore's lab website.

Publications

View all Dr. Moore's publications in PubMed.

Thomas Moore, PhD

Associate Research Scientist, Department of Internal Medicine
Director, University of Michigan Flow Cytometry Core Facility

Degrees and Fellowships

  • PhD, University of Texas Southwestern Medical Center, 1993
  • Fellowship, Pathology, University of Texas Southwestern Medical Center, 1994
  • Fellowship, Immunology, DNAX Research Institute, 1997

Research Interests

  • Pulmonary innate and adaptive immune responses
  • Pulmonary fibrosis biomarkers
  • Flow cytometry

Publications

View all Dr. Moore's publications in PubMed.

Michal Olszewski, DVM, PhD

Associate Professor, Department of Internal Medicine
Research Biologist, VA Ann Arbor Healthcare System

Degrees and Fellowships

  • DVM, Warsaw University of Life Sciences, 1988
  • PhD, Michigan State University, 1997
  • Postdoctoral Research Fellow, "Multidisciplinary Research Training in Lung Diseases", Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 03/1998 - 08/1999
  • Postdoctoral Research Fellow, Investigator Training in Pulmonary Immunology. VA Career Development/Research Enhancement Award Program, VA Medical Center, Ann Arbor, MI, 08/1999 - 10/2002

Research Interests

Scientific interest of our group focuses on the host-pathogen interaction at the interface of the adaptive and innate immunity. The effects of these interactions on the development of protective responses against fungal and bacterial pathogens are a common theme of these studies. Following areas of investigation have been established: Mechanisms involved in pathogenesis of Cryptococcus neoformans infection and persistence of this microbe are main focus of our work. The interplay between the host and microbial factors especially, the role of microbial factors, urease, laccase-lac1, ena1, pyk1, rub1, vad1 and Hsp70 homologue Ssa1 on different aspects of innate and adaptive host response. Studies of macrophage M1/M2 polarization and their plasticity in the context of cryptococcal infection Alternative activation of macrophages promotes persistence of C. neoformans we look into the mechanisms that promote and or prevent the alternative activation. These mechanisms include cytokines, direct effects of cryptococcal virulence factors, and pattern recognition receptors such as TLR9. We study how these factors affect macrophage biology in context of cryptococcal infection. Studies of the role of macrophage lysosomal damage and its effects on macrophage fungicidal activities and cryptococcal antigen cross-presentation. Differential outcomes of infections are observed in various strains of mice infected with C. neoformans. We are interested in inheritance of these factors and the evaluation how genetic differences affect phenotype of the immune response to C. neoformans. Mechanisms modulating the development of the adaptive immune responses to C. neoformans, particularly the role of cytokines, chemokines and growth factors including TNF-alpha and IL-12, CCL7 (MCP-3), CCL3 (MIP-1 alpha) and GMCSF. Effects of these factors during the early responses (dendritic cells and macrophages) and their subsequent effects on T cell response polarization are studied.

Publications

View all Dr. Olszewski's publications in PubMed.

John Osterholzer, MD

John Osterholzer, MD, conducts research on lung dendritic cell recruitment and immunobiology, pulmonary host defense against fungal organisms, and mechanisms of T cell polarization in the pulmonary microenvironment.

Publications

View all Dr. Osterholzer's publications in PubMed.

Raghu Penke, PhD

Research Fellow, Department of Internal Medicine

Degrees and Fellowships

  • BS, Andhra University, Visakhapatnam, India, 2002
  • MS, University of Hyderabad, Hyderabad, India, 2004
  • PhD, University of Pune, Pune, India, 2012
  • Fellowship, Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, 2012
  • Fellowship, Pulmonary and Critical Care Medicine, University of Michigan, 2017

Research Interests

  • Molecular regulation of fibroblast activation and tissue fibrosis
  • Mechanisms of IL13 signaling
  • Role alveolar macrophages in lung inflammation

Publications

View all Dr. Penke's publications in PubMed.

Marc Peters-Golden, MD

Marc Peters-Golden, MD, conducts research on the mechanistic aspects of lung inflammation, antimicrobial defense, and fibrosis. Using tools of molecular and cell biology, cells from diseased patients, as well as animal models of disease, we focus on the functions of two key cells in the lung, macrophages and fibroblasts, and how these cells interact with each other and with neighboring epithelial cells. Ongoing current projects include: 1) the role of extracellular vesicles in cell-cell communication in lung health and disease, and 2) cellular programs dictating aberrant fibroblast activation in pulmonary fibrosis. We are currently examining disease states including asthma, cigarette smoke-induced inflammation, lung cancer, lung infection, and idiopathic pulmonary fibrosis. Our ultimate goal is to gain novel insights into lung homeostasis and disease pathogenesis, and to identify new strategies for therapeutic targeting. The laboratory consists of a highly interactive and collaborative group of students as well as M.D. and Ph.D. postdoctoral trainees from around the world.

Publications

View all Dr. Peters-Golden's publications in PubMed.

Hallie Prescott, MD, MSc

Hallie Prescott, MD, MSc, conducts research on the long-term outcomes of acute medical illnesses.

Publications

View all Dr. Prescott's publications in PubMed.

Thomas Sisson, MD

Thomas Sisson, MD, conducts research on the plasminogen system in the pathophysiology of pulmonary fibrosis and emphysema.

Publications

View all Dr. Sisson's publications in PubMed.

Michael Sjoding, MD, MSc

Michael Sjoding, MD, MSc, conducts research on pulmonary and critical care and hospital medicine, with a focus on inpatient hospital quality measures and their unintended consequences, the epidemiology of critical illness, and methods for critical care delivery. 

Publications

View all Dr. Sjoding's publications in PubMed.

Theodore Standiford, MD

Theodore Standiford, MD, conducts research on the role of specific cells, cytokines, antimicrobial peptides and pathogen recognition receptors in the generation of protective innate immune responses of the lung. The epigenetic regulation of innate immunity in sepsis and acute lung injury is an active area of both animal and human based translational research. In human trials, Dr. Standiford has investigated mechanisms of lung injury in ARDS and the effect of growth factor administration on outcome in ARDS patients and in patients at risk for the development of ARDS.

Publications

View all Dr. Standiford's publications in PubMed.

Thomas Valley, MD, MSc

Thomas Valley, MD, MSc, conducts research on decision-making in the intensive care unit for patients, families, and clinicians. 

Publications

View all Dr. Valley's publications in PubMed.

Ragini Vittal, PhD

Ragini Vittal, PhD, conducts research on IL-17A-mediated epithelial injury in lung fibrosis and chronic rejection post-transplant, and complement activation in lung fibrosis.

Publications

View all Dr. Vittal's publications in PubMed.

Eric White, MD, MS

Eric White, MD, MS, conducts research on interstitial lung diseases, biomarkers, and biorepository and registry maintenance.

Publications

View all Dr. White's publications in PubMed.

Xiaofeng Zhou, PhD

Research Investigator, Department of Internal Medicine

Degrees and Fellowships

  • BA, Entomology, Zhejiang University, Hangzhou, China, 1989
  • MSc, Ecology, Chinese Academy of Sciences, Institute of Plant Physiology and Ecology, Shanghai, China, 1995
  • PhD, Physiology, The Hebrew University of Jerusalem, Rehovot, Israel, 2001
  • Postdoctoral Fellowship: Hormonal regulation of adult development, Department of Biology, University of Washington, 2007
  • Postdoctoral Fellowship: Signal transduction in cancer, Department of Biological Sciences, University of Toledo, 2009
  • Postdoctoral Fellowship: Cell fusion in tumorigenesis, Department of Surgery, University of Michigan, 2012
  • Postdoctoral Fellowship: Impacts of stem cell transplantation in immunity, Division of Pulmonary Medicine and Critical Care, University of Michigan, 2016

Research Interests

  • Pulmonary complications post hematopoietic stem cell transplantation
  • Differentiation of helper T cells
  • Dendritic cell subsets and functions
  • Tolerance and autoimmunity

Publications

View all Dr. Zhou's publications in PubMed.