Clinical Research

"My role this year has expanded to include both clinical and health services research. There are endless opportunities to capitalize on the inherent, bidirectional synergies in these arenas and I look forward to collaborating with my clinical and health services research colleagues to take full advantage of them." - Rodica Pop-Busui, MD, PhDLearn more about Dr. Pop-Busui.

Clinical & Health Services Research Connection

Internal Medicine has a sizable and accomplished history in health services research. Researchers from our department make up the largest group within U-M’s Institute for Healthcare Policy & Innovation (IHPI). Because our health services research footprint is so vast, we have the perfect opportunity to stimulate the development of clinical research projects that address pressing topics already being investigated by our IHPI colleagues, from healthy aging to the opioid epidemic. As our clinical trialists identify effective interventions, our outcomes researchers can examine them in clinical practice. And if an intervention falls short in practice, our trialists can compare alternatives. With our health services and clinical researchers working together, we can make quicker advancements to improve patient care.

The Clinical Trials Academy, offered jointly by the Department of Internal Medicine and the Medical School, is a hands-on training program in clinical research and clinical trial design. Learn more.

Anna Mathew, MD is our latest Clinical Research Spotlight. She is active in translational research studying chronic kidney disease, diabetic kidney disease, and cardiovascular disease in chronic kidney disease using metabolomics and proteomics approaches. Learn more.

Funded by the National Institutes of Health, Michigan Medicine and five other U.S. research institutions launch the first-ever multicenter network to study diabetic foot ulcers. Learn more.

Michigan Medicine launch two new clinics aimed at treating and studying COVID-19's long-term outcomes in vulnerable adult and pediatric populations. Read more.

The Michigan Medicine/Peking University Health Science Center (PKUHSC) Joint Institute for Translational and Clinical Research funded 12 projects for 2019, 4 of which were co-led by Department of Internal Medicine researchers. Learn more.

No More Finger Pricks: A Continuous Glucose Monitor Benefits Patients with Diabetes in More Ways Than One

Rodica Busui, MD, PhD finds that pairing basal insulin with continuous glucose monitoring improved blood sugar and quality of life for adults with type 2 diabetes. Read more.

Blood Test Shows Promise for Predicting Treatment Response in Metastatic HPV-Positive Throat Cancer

Paul Swiecicki, MD and team work to develop a blood test that could signal whether treatment is working months earlier than standard imaging scans. Read more.

New Potential Therapy for Fatty Liver Disease

Elif Oral, MD, MS finds that the hormone leptin can be leveraged as a therapeutic agent to move fat out of the liver. Read more

Deep Learning Algorithm Detects Acute Respiratory Distress Syndrome (ARDS) with Expert-Level Accuracy

Michael Sjoding, MD and team develop a new artificial intelligence algorithm that analyzes chest x-rays and identifies ARDS with higher accuracy than many physicians. Read more.

What Are the Effects of Terlipressin When Treating HRS-1?

Pratima Sharma, MBBS, MD, MS discusses her clinical trial that looked into the efficacy and safety of terlipressin plus albumin in adults with type 1 hepatorenal syndrome (HRS-1).
Read more.