Clinical Research

"My role this year has expanded to include both clinical and health services research. There are endless opportunities to capitalize on the inherent, bidirectional synergies in these arenas and I look forward to collaborating with my clinical and health services research colleagues to take full advantage of them." - Rodica Pop-Busui, MD, PhDLearn more about Dr. Pop-Busui.

Clinical & Health Services Research Connection

Internal Medicine has a sizable and accomplished history in health services research. Researchers from our department make up the largest group within U-M’s Institute for Healthcare Policy & Innovation (IHPI). Because our health services research footprint is so vast, we have the perfect opportunity to stimulate the development of clinical research projects that address pressing topics already being investigated by our IHPI colleagues, from healthy aging to the opioid epidemic. As our clinical trialists identify effective interventions, our outcomes researchers can examine them in clinical practice. And if an intervention falls short in practice, our trialists can compare alternatives. With our health services and clinical researchers working together, we can make quicker advancements to improve patient care.

The Clinical Trials Academy, offered jointly by the Department of Internal Medicine and the Medical School, is a hands-on training program in clinical research and clinical trial design. Learn more.

Anna Mathew, MD is our latest Clinical Research Spotlight. She is active in translational research studying chronic kidney disease, diabetic kidney disease, and cardiovascular disease in chronic kidney disease using metabolomics and proteomics approaches. Learn more.

Funded by the National Institutes of Health, Michigan Medicine and five other U.S. research institutions launch the first-ever multicenter network to study diabetic foot ulcers. Learn more.

Michigan Medicine launch two new clinics aimed at treating and studying COVID-19's long-term outcomes in vulnerable adult and pediatric populations. Read more.

The Michigan Medicine/Peking University Health Science Center (PKUHSC) Joint Institute for Translational and Clinical Research funded 12 projects for 2019, 4 of which were co-led by Department of Internal Medicine researchers. Learn more.

Clinical Context Crucial When Treating Thyroid Cancer in Older Adults

Megan Haymart, MD and team find that providers should consider clinical context, including comorbidities, when diagnosing and managing thyroid cancer in older adults. Read more.

Suicide Among Female Nurses Is Double That of the General Female Population

Julie Bynum, MD, MPH and colleagues find that female nurses are roughly twice as likely to die by suicide than the general female population and 70% more likely than female physicians. Read more.

Does Public Policy Affect Alcohol-Related Liver Disease Deaths?

Neehar Parikh, MD, MS; Jessica Mellinger, MD, MSc; and Elliot Tapper, MD examine how statewide policies impact mortality rates among individuals with alcohol-related liver disease. Read more.

Patients with Metastatic Breast Cancer and High Mutational Burden Benefit from Pembrolizumab

Findings from a recent study led by Ajjai Alva, MBBS support the recent FDA approval of pembrolizumab for patients with metastatic breast cancer whose tumors were found to have a high number of mutations. Read more.

Repurposing Tocilizumab in Scleroderma Patients May Prevent Early Lung Disease

Dinesh Khanna, MD, MSc, David Roofeh, MD, and team find that an anti-inflammatory drug used in rheumatoid arthritis can preserve lung function in patients with systemic sclerosis. Read more.

Women Experience Faster Cognitive Decline with Age

Deborah Levine, MD, MPH leads research that finds higher baseline cognition scores for aging women, but a more rapid drop once cognitive decline begins. Read more.