AASLD 2019

The American Association for the Study of Liver Diseases (AASLD) is the leading organization of scientists and healthcare professionals committed to preventing and curing liver disease.

This year, our faculty continued to earn prestigious AASLD awards and to play key roles in the leadership of AASLD. Please see a daily compilation of the main sessions during which our faculty, fellows, and researchers are presenting at The Liver Meeting, November 8–12, 2019, in Boston, Massachusetts.

Awards

Vincent Chen, MD, MS
Clinical Lecturer
Early Career Investigator Award in Clinical/Translational Science

Mary Thomson, MD
Advanced Transplant Hepatology Fellow
Advanced/Transplant Hepatology Award

Leadership Positions

Hari Conjeevaram, MD, MS – Professor
Training and Workforce Committee

Robert Fontana, MD – Professor
Clinical Research Committee
AASLD Nominating Committee
Hepatology, Editorial Board
Hepatology Communications, Editorial Board

Anna Lok, MD – Professor
Global Outreach and Engagement Committee, Global Advisory Council Chair
Hepatology, Editorial Board

John C. Magee, MD – Professor
Scientific Program Committee
Surgery and Liver Transplantation Committee, Chair

Jessica Mellinger, MD, MS – Assistant Professor
Hepatology Communications, Editorial Board
Clinical Liver Diseases, Editorial Board

Neehar Parikh, MD, MS – Assistant Professor
Practice Metrics Committee

Pratima Sharma, MD, MS – Associate Professor
Publications Committee
Public Policy Committee
Liver Transplantation, Associate Editor

Grace Su, MD – Professor
Annual Meeting Education Committee, Chair
Scientific Program Committee
Maintenance of Certification (MOC) Committee

Andrew Tai, MD, PhD – Associate Professor
Research Awards Committee

Elliot Tapper, MD – Assistant Professor
Practice Metrics Committee, Vice Chair
Hepatology Communications, Editorial Board
Hepatology, Editorial Board

The Liver Meeting® Program - Moderators, Chairs

Sunday, November 10, 2019

Parallel 2: Hepatitis C: Long-Term Outcomes and Unique Populations
CC, Room 304/306
8:30-10:00 am
Moderators: Grace L. Su, Raymond Chung

Parallel 11: Liver Transplant: Renal and Metabolic Issues
CC, Room 304/306
2:00-3:30 pm
Moderators: Pratima Sharma, Glen Lutchman

Parallel 14: HCC Translational and Biomarkers
CC, Ballroom BC
4:30-6:00 pm
Moderators: Denise Harnois, Neehar D. Parikh

#LiverTwitter: An Emerging Tool for Liver Education and Research
CC, Room 312
2:00-3:30 pm
Chairs: Elliot B. Tapper, Rohit S. Satoskar

Postgraduate Course

Saturday, November 9, 2019

Session I – Precision Medicine in 2019
CC Auditorium
8:45–9:05 am
Precision medicine and patients at risk for drug-induced liver injury
Robert Fontana

Workshops, Courses, President's Choice Lecture, Global Forum

Friday, November 8, 2019

Career Development Workshop
CC, Room 311
2:20 pm
How to be a good mentee and identify mentors/sponsors to launch your career
Elliot B. Tapper

2:50 pm
How I make time for myself and my work
Monica Tincopa

Saturday, Nov 9, 2019

Meet-the-Professor Luncheon (MTP) 1
12:00 pm
Ask the expert on cirrhosis: What are the best strategies to avoid readmissions?
Elliot B. Tapper, Fasiha Kanwal

Transplant Surgery Workshop
CC, Room 304/306
2:50 pm
Case Presentation Stimulated Panel Discussion/Q&A
Monica Tincopa

Sunday, Nov 10, 2019

Diversity Workshop
CC, Room 311
10:35 am
Creating solutions for racial and ethnic disparities in health
John Carethers

Hepatology Associates Course
Sheraton, Constitution Ballroom
11:25 am
Hepatitis B update
Anna S. Lok

#LiverTwitter: An Emerging Tool for Liver Education and Research
CC, Room 312
2:05 pm
Setting up your Twitter, sending your first Tweet
Elliot B. Tapper

2:25 pm
Running a divisional Twitter account
Neehar Parikh

Value-Based Medicine in Hepatology
Sheraton, Republic Ballroom
3:25 pm
Telehealth for high-value liver care
Grace L. Su

President's Choice Lecture
CC, Auditorium
4:00 pm
Global Health
Tadataka Yamada

Monday, November 11, 2019

Early Morning Workshop - EMW–43
6:45 – 7:45 am
Quality and safety for hospitalized patients with cirrhosis
Elliot B. Tapper

Global Forum – Alcohol-Related Liver Disease (ALD)
CC, Room 312
3:20 PM
AASLD/U.S. Perspective
Jessica Mellinger

Abstracts – Oral Presentations

Sunday, November 10, 2019

Parallel 5: Health Service Research: Patient Centered Outcomes
CC, Room 312
10:30 am
0055
Patients with decompensated cirrhosis are not receiving the medications they need while receiving medications they do not need
Mary Thomson, Anna S. Lok, Elliot B. Tapper

11:45 am
0060
A prospective study to define the contemporary health state utilities for persons with cirrhosis
Chelsey Foster, Samantha Nikirk, Jad Baki, Neehar D. Parikh, Elliot B. Tapper        

Parallel 11: Liver Transplant: Renal and Metabolic Issues
CC, Room 304/306
3:15 pm
0096
Muscle mass measurements can be automated using deep learning
Nicholas Wang, Stewart Wang, Grace L. Su

Parallel 16: Health Services Research: Healthcare Delivery and Access
Sheraton, Republic Ballroom
4:30 pm
0121
Gastroenterology consultation improves mortality and healthcare utilization after hepatic encephalopathy: The first population-based outcomes study of Americans with cirrhosis
Elliot B. Tapper, Devin Aberasturi

5:00 pm
0123
Inpatient access to specialty care for cirrhosis-related admissions and its impact on length of stay, mortality, and 30-day readmissions in two large national cohorts
Marina Serper, David E. Kaplan, Tamar H Taddei, Elliot B. Tapper

Monday, November 11, 2019

Parallel 22: HBV Epidemiology Prevention
CC, Ballroom A
9:45 am
0162
Hepatic fat and steatohepatitis in a large multiethnic North American cohort of adults and children with chronic hepatitis B
Mandana Khalili, David Kleiner, Wendy King, Richard K. Sterling, Marc G. Ghany, Raymond T. Chung, Philip Rosenthal, Lisker-Melman, Rageshree Ramachandran, Ahul Bhan, Anna S. Lok

Parallel 29: HCC Treatment: Medical Approaches
CC, Ballroom BC
10:30
0199
Direct-acting antiviral therapy is associated with improved survival in patients with a history of hepatocellular carcinoma: A multicenter North American cohort study
Amit G. Singal, Nicole E. Rich, Neil Mehta, Andrea D. Branch, Anjana A. Pillai, Maarouf A. Hoteit, Michael Volk, Mobolaji Odewole, Steven J. Scaglione, Jennifer E. Guy, Adnan Said, Jordan J. Feld, Binu John, Catherine T. Frenette, Parvez S. Mantry, Amol S. Rangnekar, Omobonike Oloruntoba, Michael D Leise, Janice Jou, Kalyan Ram Bhamidimarri, Laura M. Kulik, George Ioannou, Annsa Huang, Tram T. Tran, Hrishikesh V. Samant, Renumathy Dhanasekaran, Andres Duarte-Rojo, Reena J. Salgia, Sheila L. Eswaran, Prasun K. Jalal, Avegail Flores, Sanjaya Kumar Satapathy, Neehar D. Parikh, Caitlin Murphy

11:00 am
0201
Financial burden is common in U.S. patients with cirrhosis and associated with lower HCC surveillance receipt
Amit G. Singal, Katharine McCallister, Cynthia Ortiz, Jennifer Kramer, Song Zhang, Aisha Khan, Yan Liu, Nicole E. Rich, Neehar D. Parikh, Jasmin Tiro, Purva Gopal, Simon Lee, Caitlin Murphy, Ruben Hernaez

Parallel 31: Hepatotoxicity
CC, Room 302
10:30 am
0211
Discovery of ERAP2 gene expression as a risk factor for drug-induced liver injury due to amoxicillin–clavulanic acid
Paola Nicoletti, Federico Innocenti, Amy Etheridge, Naga P. Chalasani, Robert J. Fontana, Yi-Ju Li, Joseph Odin, Jose Serrano, Andrew Stolz, Guruprasad Aithal, Ann K. Daly, Paul B. Watkins, DILIN Investigators

10:45 am
0212
Increasing episodes of hepatotoxicity in the Drug-Induced Liver Injury Network associated with kratom, a botanical product with opioid-like activity
Victor J. Navarro, Joseph Odin, Jawad Ahmad, Paul H. Hayashi, Robert J. Fontana, Hari S. Conjeevaram, Bharathi Avula, Ikhlas Khan, Huiman Barnhart

Parallel 35: NAFLD and NASH: Epidemiology and Outcomes
Sheraton, Constitution Ballroom
3:15 pm
0240
Incidence of achieving weight loss goals in usual clinical practice: results for the TARGET-NASH observational cohort
Miguel H. Malespin, Alfred Sidney Barritt IV, Stephanie Watkins, Cheryl Schoen, Monica A. Konerman, Karen Corbin, Huy N. Trinh, L Michael Weiss, K Rajender Reddy, Rohit Loomba, Nyingi Kemmer, Anna S. Lok

Parallel Session: Late-Breaking Abstracts Oral Session I
CC, Auditorium
3.30 PM
LO5
The CONFIRM Study: A North American randomized controlled trial (RCT) of terlipressin plus albumin for the treatment of hepatorenal syndrome type 1 (HRS-1)
Florence Wong, Michael P Curry, K. Rajender Reddy, Raymond A Rubin, Michael K Porayko, Stevan Gonzales, Khalid Mumtaz, Nicholas Lim, Douglas Simonetto, Pratima Sharma, Arun Sanyal, Marlyn Mayo, Todd Frederick, S. Chris Pappas, Khurram Jamil on behalf of the CONFIRM Study Investigators

Abstracts – Poster Presentations

Friday, November 8, 2019

0318
Prognostic nutritional index is associated with improved survival in patients with hepatocellular carcinoma

Nicole E. Rich, Aarthi Parvathaneni, Adam C Yopp, Ahana Sen, Mobolaji Odewole, Ju Dong Yang, Yujin Hoshida, Neehar D. Parikh, Jorge A. Marrero, Amit G. Singal

0320
Prospective evaluation of benefits and harms of HCC surveillance in a cirrhosis patient population

Sruthi Patibandla, Joseph Obi Jr., Hannah Fullington, Katharine McCallister, Nicole E. Rich, Neehar D. Parikh, Purva Gopal, Jorge A. Marrero, Amit G. Singal

0322
Comparison of characteristics and prognosis of U.S. – Japan hepatocellular carcinoma patients detected under surveillance
Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Atsushi Hiraoka, Neehar D. Parikh, Amit G. Singal

0335
Multicenter cohort study of thermal ablation versus stereotactic body radiation therapy for hepatocellular carcinoma
Andrew Moon, Dawn Owen, Hannah Kim, Emily Sanders, Christian Beyer, Katrina A McGinty, Lauren M Burke, Paul H. Hayashi, Joel E Tepper, Paula D Strassle, Theodore S Lawrence, Charles S Mayo, Mishal Mendiratta-Lala, Neehar D. Parikh, Amit G. Singal, Karyn A Goodman, Marina Moskalenko, Daniel R Simpson, John Do, Yuko Kono, Steven C Rose, Jona A Hattangadi-Gluth, David A. Gerber, Kyle Wang

0369
Transarterial chemoembolization versus transarterial radioembolization for patients with hepatocellular carcinoma: a meta-analysis
Andrew Brown, Ihab A Kassab, Vincent L Chen, Whitney A Townsend, Amit G. Singal, Neehar D. Parikh

0390
Cost effectiveness of hepatocellular carcinoma surveillance: An assessment of benefits and harms
Neehar D. Parikh, Amit G. Singal, David Hutton, Elliot B. Tapper

0407
Opioid prescriptions are associated with hepatic encephalopathy in a national cohort of privately-insured patients with compensated cirrhosis
Andrew Moon, Yue Jiang, Shari S Rogal, Elliot B. Tapper, Sarah Rosanna Lieber, Alfred Sidney Barritt IV

0491
Effectiveness of tenofovir alafenamide in patients with chronic hepatitis B treated in usual clinical practice: Results from the TARGET-HBV observational cohort study
David Eric Bernstein, Huy N. Trinh, Eugene R. Schiff, Coleman I Smith, Richard Zink, Anna S. Lok

0615
Diagnostic and treatment delays are common in patients with hepatocellular carcinoma

Ashwin Rao, Amit G. Singal, Neehar D. Parikh, Nicole E. Rich

0618
The impact of socioeconomic status on cirrhosis and hepatocellular carcinoma in the United States
Roselyn Nsenga, Sophia Tzavaras, Daniel Waldo, Amit G. Singal, Elliot B. Tapper, Neehar D. Parikh

0724
Patient knowledge deficits are associated with lower HCC surveillance receipt
Amit G. Singal, Katharine McCallister, Cynthia Ortiz, Jennifer Kramer, Song Zhang, Yan Liu, Aisha Khan, Nicole E. Rich, Jasmin Tiro, Neehar D. Parikh, Simon Lee, Caitlin Murphy, Ruben Hernaez

0727
Significant depression and anxiety are common in U.S. patients with cirrhosis
Amit G. Singal, Nicole E. Rich, Katharine McCallister, Cynthia Ortiz, Aisha Khan, Jennifer Kramer, Song Zhang, Elliot B. Tapper, Neehar D. Parikh, Jasmin Tiro, Simon Lee, Caitlin Murphy, Ruben Hernaez

0737
Patient-reported outcomes associated with chronic hepatitis B viral (HBV) infection in a large North American cohort: A cross-sectional analysis
Donna M. Evon, Hsing-Hua Lin, Mandana Khalili, Robert J. Fontana, Colina K. Yim, Abdus Wahed, Michael W Fried, Jay H. Hoofnagle, Hepatitis B Research Network (HBRN)

Saturday, November 9, 2019

0828
A prospective study of hepatitis E virus infection in North American patients with severe acute liver injury

Robert J. Fontana, Ronald E Engle, Michelle Gottfried, Hanje James, Bilal Hameed, Valerie L Durkalski-Mauldin, William M Lee, Patrizia Farci

0833
Does acute hepatitis C virus (HCV) infection ever lead to acute liver failure?
Jody A. Rule, Giuliana Cerro, R. Todd Stravitz, Brendan Martin McGuire, Robert J. Fontana, Dr. Jorge L. Rakela, William M Lee

0842
Growth rates of untreated hepatocellular carcinoma in patients with cirrhosis: A multicenter cohort study

Nicole E. Rich, Binu John, Neehar D. Parikh, Ian Rowe, Neil Mehta, Gaurav Khatri, Smitha Thomas, Munazza Anis, Mishal Mendiratta-Lala, Christopher Hernandez, Mobolaji Odewole, Latha T. Sundaram, Venkata R Konjeti, Shishir Shetty, Tahir Shah, Hao Zhu, Adam C Yopp, Yujin Hoshida, Jorge A. Marrero, Amit G. Singal

0881
No association between hepatocellular carcinoma surveillance and survival among patients with cirrhosis in the Optum database
Vincent L Chen, Elliot B. Tapper, Amit G. Singal, Neehar D. Parikh

0948
Low incidence of clinical outcomes in patients with chronic HBV infection in the era of nucleos(t)ide analogue (NA) therapy: Report from the Hepatitis B Research Network (HBRN) Adult Cohort Study
Anna S. Lok, Harry L. A. Janssen, Christina Lalama, Michael W Fried, Steve Belle, Robert P Perrillo, Dr. Marc G. Ghany, Mandana Khalili, Hepatitis B Research Network (HBRN)

0959
Incidence of HBsAg loss and HBeAg seroreversion among adults and children with HBeAg-negative chronic hepatitis B: Prospective analysis of a multi-ethnic North American cohort
Norah Terrault, Junyao Wang, Marc G. Ghany, Jordan J. Feld, Mandana Khalili, Philip Rosenthal, Robert J. Fontana, Mauricio Lisker-Melman, Richard K. Sterling, Raymond T. Chung, Harry L. A. Janssen

1131
The proportion of marijuana users among adult liver transplant candidates is increasing over time
Alisa Likhitsup, Gerald Winder, Ammar Hassan, Naba Saeed, Christopher J. Sonnenday, Robert J. Fontana

Sunday, November 10, 2019

1372
Bariatric surgery is associated with increased risk of alcohol-related cirrhosis and alcohol misuse
Jessica L. Mellinger, Kerby Shedden, Gerald Winder, Anne Fernandez, Brian Lee, Jennifer Waljee, Robert J. Fontana, Michael Volk, Frederic C Blow, Anna S. Lok

1738
Routinely available noninvasive tests perform well in identifying patients with advanced fibrosis due to NASH: Data from the TARGET-NASH observational cohort
Alfred Sidney Barritt IV, Anna S. Lok, K Rajender Reddy, L Michael Weiss, Roberto J. Firpi, Paul J. Thuluvath, Huy N. Trinh, Stephen Djedjos, Richard Haubrich, Andrew Billin, Bruce Koch II, Richard Zink, Arun J Sanyal, Kenneth Cusi, Brent A Neuschwander-Tetri

Monday, November 11, 2019

1855
Dependence of extrahepatic cholangiocyte proliferation on WNT signaling in in vivo murine and in vitro organoid co-culture models
Junya Shiota, Nureen Hanisah Mohamad Zaki, Linda Samuelson, Nataliya Razumilava

1892
Genome-wide association study of alanine transaminase and aspartate transaminase identifies diverse disease pathologies and effects on metabolic traits
Vincent L Chen, Xiaomeng Du, Yanhua Chen, Samuel Handelman, Elizabeth K. Speliotes

1905
Genetic variants that associate with liver cirrhosis have pleiotropic effects on human traits
Vincent L Chen, Yanhua Chen, Xiaomeng Du, Samuel Handelman, Elizabeth K. Speliotes

1906
Genome-wide association study for serum alkaline phosphatase identifies novel associations that affect liver and metabolic disease
Vincent L Chen, Xiaomeng Du, Yanhua Chen, Samuel Handelman, Elizabeth K. Speliotes

1910
GWAS of alcohol consumption in the UK biobank identifies variants that associate with metabolic and tissue-specific alcohol disease
Daniel Seung Kim, Xiaomeng Du, Yanhua Chen, Yatong K Li, Samuel Handelman, Jessica L. Mellinger, Elizabeth K. Speliotes

1911
Genetic variation in genes in the FXR/RXR pathways underlies effects on serum lipids and NAFLD
Samuel Handelman, Xiaomeng Du, Yanhua Chen, Elizabeth K. Speliotes

2036
A fucosylated kininogen-based biomarker panel is highly accurate for early detection hepatocellular carcinoma in patients with cirrhosis: A phase III biomarker evaluation
Anand Mehta, Mengjun Wang, Neehar D. Parikh, Nabihah Tayob, Jorge A. Marrero, Amit G. Singal

2044
Validation of GALAD for early detection of hepatocellular carcinoma in patients with cirrhosis
Neehar D. Parikh, Nabihah Tayob, Joy Lau, Cristian Saenz De Viteri, Jorge A. Marrero, Amit G. Singal

2232
Sex-specific reduction in liver damage and fat accumulation in a murine model of Lyplal1 KO
Rishel Vohnoutka, Yash Hegde, Yue Chen, Brian D. Halligan, Elizabeth K. Speliotes

2344
Upregulation of hedgehog signaling and inflammatory cytokines in the injury-induced proliferative response of extrahepatic bile duct cells
Nureen Hanisah Mohamad Zaki, Junya Shiota, Linda Samuelson, Nataliya Razumilava