Research

Division of Pulmonary & Critical Care Medicine Researchers

Research performed within the Division of Pulmonary & Critical Care Medicine has greatly impacted our understanding of basic lung biology, disease pathogenesis, and targeted therapeutics. NIH grant funding for research within the Division exceeds 13 million dollars annually. Our investigative portfolio is comprehensive, with specific areas of emphasis including pulmonary inflammation, lung injury and repair, fibrotic lung disorders, host defense, lung transplantation, and lung cancer. 

New major areas of modern biology have emerged, including genetics/genomics, metagenomics, proteomics, metabolomics, stem cell biology, computational biology, and the microbiome. Researchers in the division participate in large multidisciplinary and multicenter disease-specific programs and networks in interstitial lung disease (IPFnet, COMET, LTRC), COPD (SPIROMICS, COPD gene, LTRC), and Acute Lung Injury (SCOR, SCCOR, ARDSnet). 

Emerging fields of patient-oriented research have been added or expanded, including health services research and sleep. Active areas of health services research include long-term functional outcomes in survivors of critical illness, nosocomial infection, delirium in the ICU, health care utilization, and health care policy.

Research Highlights

Study Hints At Why Older People Are More Susceptible to the Flu

U-M researchers investigate why cells called alveolar macrophages, the first line of defense in the lungs, appear to be compromised with age.

Anti-Anaerobic Antibiotics Associated with Increased Risk of Mortality in Critically Ill Patients

Robert Dickson, MD; Rishi Chanderraj, MD; and team find that early treatment with specific antibiotics depletes the body of gut anaerobes that protect against pneumonia, organ failure and mortality.

Bronchodilators Don’t Improve Smoking-Related Respiratory Symptoms in People Without COPD

A study led by MeiLan Han, MD, MS shows the importance of finding new, effective therapies for patients without COPD.