Research Professor, Department of Internal Medicine
Medical Science Research Building II
1150 West Medical Center Drive, Room 2570
Ann Arbor, MI 41809
- PhD, University of Texas Health Science Center at Houston, 1984
Applications of transgenic technology to genome engineering. As the Director of the University of Michigan Transgenic Animal Model Core I am focused on generating new mouse and rat models with genetic modifications that can serve as models of human genetic disease. The methodology to manipulate the genome in mice and rats is constantly evolving and changing. The application of cutting edge approaches to genome engineering can accelerate the pace of delivering useful transgenic mice, transgenic rats, gene-targeted mice produced by genetically engineered mouse embryonic stem cells, and gene knockout rats to improve our understanding gene function. These animal models are important for preclinical translational studies of therapies designed to improve the health of human patients.