Research

Vivian Cheung, M.D.

vgcheung@umich.edu
In the Cheung lab, we combine computational and experimental methods to study normal variation in human traits and genetics of complex diseases. We assess the extent of individual differences in cellular phenotypes such as gene expression and organelle function. Then, we treat the variable phenotypes as quantitative traits to map and characterize molecularly their regulators. We are particularly interested in regulators that affect transcription and RNA processing. Our studies focus on normal human cells at baseline homeostatic states; however, we are also interested in cellular responses to stress including DNA damage, protein load and metabolic perturbations. By studying regulation in normal cells, we gain insights into how dysregulations lead to diseases. While our interest is in human biology, recently, we have taken advantage of yeast genetics to complement our studies.

Louis Dang, M.D., Ph.D.

louisdan@med.umich.edu

Dr. Dang studies genetic mechanisms of epilepsy in the laboratory of Dr. Jack Parent. He is interested in how variants in sodium channel genes cause epilepsy and is developing novel therapies for these diseases. He also studies how variants in genes in the mammalian target of rapamycin (mTOR) pathway result in cortical malformations and epilepsy. Dr. Dang employs human induced pluripotent stem cells derived into two-dimensional and three-dimensional neural cultures to model genetic epilepsies.

Timothy Hoban, M.D.

thoban@med.umich.edu
Dr. Hoban is a pediatric neurologist, sleep specialist, and epileptologist whose research interests focus primarily on identifying the causes of sleep disorders in children, and on improving their treatment.

Sucheta Joshi, M.D.

suchetaj@med.umich.edu
Dr. Joshi is a pediatric epileptologist. Her research focuses on understanding the impact of epilepsy on quality of life in adolescents.

Steven Leber, M.D., Ph.D.

leber@med.umich.edu

Dr. Leber is interested the best clinical management of children with conversion disorders, in the application of the internet in medicine, and in pediatric headache, including evaluation of referral patterns from primary physicians and in headache treatment.

Patricia Robertson, M.D.

prob@med.umich.edu
Dr. Robertson's research interests focus on development of more effective therapies for pediatric brain tumors. Related research focuses on refining clinical methods for the evaluation of response to treatment, for the assessment of outcomes, and for analyzing late effects of therapy on children with these tumors.

Erin Fedak Romanowksi, D.O. 

fedake@med.umich.edu
Dr. Fedak is a pediatric epileptologist with an interest in global health.  She is working on global health program development in collaboration with other faculty in the Department of Pediatrics.

Renée Shellhaas, M.D.

shellhaa@med.umich.edu

Dr. Shellhaas’ multidisciplinary research program is focused on clinical neurophysiology for newborns who require intensive care. Her research team has developed novel analytic approaches for multimodality neuromonitoring with electroencephalography (EEG), amplitude-integrated EEG, near infrared spectroscopy, and polysomnography. Her work on early-life seizures and epilepsies includes leadership for multicenter studies of the impact of treatment strategies for neonatal seizures on neurodevelopment, epilepsy, and family well-being, as well as on optimizing clinical care for children with early-life epilepsy through collaborative research on the comparative effectiveness of treatments for infantile spasms and development of a learning healthcare system for pediatric epilepsy.

Faye Silverstein, M.D.

fsilvers@med.umich.edu

Dr. Silverstein’s research interests focus on neonatal brain injury and neuroprotection. Her clinical research focuses on neurocritical care. She has been the lead neurology Co-Investigator on the pediatric intensivist led multi-center clinical trial to evaluate Therapeutic Hypothermia after Resuscitation from Pediatric Cardiac Arrest.  Her laboratory research focus is on the delineation of mechanisms of neurodegeneration, and the development of novel neuroprotection strategies (in particular, combination therapies that incorporate hypothermia) in neonatal rodent brain injury models. 

Rachel Gottlieb-Smith, M.D.

smithgot@med.umich.edu

Dr. Gottlieb-Smith’s research interests are in medical education.  Through qualitative research, she explores how medical students decide on a career path, particularly with respect to neurology.
Dr. Smith applies quantitative methods, machine learning algorithms, and data driven analysis to the study of EEG signal with the goals of improving the way that human EEG is described and analyzed and improving the clinical utility of quantitatively derived biomarkers. He works in the lab of Dr. Bill Stacey. 

Garnett Smith, M.D.

smgarnet@med.umich.edu

Dr. Smith applies quantitative methods, machine learning algorithms, and data driven analysis to the study of EEG signal with the goals of improving the way that human EEG is described and analyzed and improving the clinical utility of quantitatively derived biomarkers. He works in the lab of Dr. Bill Stacey. 

Julie Ziobro, M.D.

ziobroj@med.umich.edu

Dr. Ziobro’s research involves studying basic mechanisms and novel-therapeutic targets of genetic epilepsies utilizing rodent and stem cell cultures. She is working in the lab of Dr. Jack Parent and funded by the Department of Pediatrics Child Health Research K12 award.