Presentations & Posters

2019 American College of Rheumatology (ACR) Annual Meeting

Below are the Michigan Medicine physicians and researchers who are participating in the 2019 American College of Rheumatology (ACR) Annual Meeting taking place November 8 - 13, 2019 in Atlanta, GA. The Michigan Medicine Alumni Reception is is taking place on Monday, November 11, from 6:00 to 8: 30, at The Park Bar.

Saturday, November 9

1:30 pm | B312-B314
Session: 2S003 BRC: Mucosal Immunity in Rheumatologic Disease Pathogenesis
Title: Innate Immunity of the Skin in the Development of SLE
Speaker: J. Michelle Kahlenberg, MD, PhD

4:30 - 8:00
Opening Lecture, Awards and Reception

Sunday, November 10

9:00 am | Hall B5
Session: T Cell Biology & Targets in Autoimmune & Inflammatory Disease
Title: Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
Presenting Author: Jeff Ruth, PhD

9:00 am | Hall B5
Session: SLE – Animal Models Poster
Title: Ultraviolet Light Induces Increased T Cell Activation in Lupus-Prone Mice via Type I Interferon-Dependent Inhibition of T Regulatory Cells
Presenting Author: J. Michelle Kahlenberg, MD, PhD

9:00 am | Hall B5
Session: SLE – Animal Models
Title: Potent Anti-Neutrophil Properties of the Natural Compound 6-Gingerol in Models of Lupus and Antiphospholipid Syndrome
Presenting Author: Ramadan Ali, PhD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Clinical Poster I
Title: Relationship Between High-Resolution Computer Tomography and FVC% Predicted for Classification of Pulmonary Hypertension in Systemic Sclerosis
Presenting Author: Sara Jaafar, MD

9:00 am | Hall B5
Session: Cytokines & Cell Trafficking
Title: Citrullination of Interleukin 6 Augments Its Proinflammatory Capacity and Signaling Potency Through Interleukin-6 Receptor in Rheumatoid Arthritis
Presenting Author: M. Asif Amin, FSc, MBBS

9:00 am | Hall B5
Session: RA – Treatments I: Novel Treatments
Title: Evidence to Guide Glucocorticoid Tapering Is Lacking in RA
Presenting Author: Beth Wallace, MD, MS

9:00 am | Hall B5
Session: Innate Immunity
Title: Beta-2 Glycoprotein I as a DNA- and NET-binding Protein
Presenting Author: Kelsey Gockman, BS

9:00 am | Hall B5
Session: Antiphospholipid Syndrome
Title: Antiphospholipid Syndrome-Associated Preeclampsia Is Defined by a Distinct Clinical Phenotype
Presenting Author: Shashank Cheemalavagu

9:00 am | Hall B5
Session: Antiphospholipid Syndrome
Title: Elevated Levels of the Neutrophil Extracellular Trap-binding Protein LILRA3 in Primary Antiphospholipid Syndrome
Presenting Author: Hui Shi, MD, PhD

9:00 am | Hall B5
Session: Antiphospholipid Syndrome
Title: Metabolomics Analysis Identifies Biomarkers for APS and Suggests a Potential New Pathway Related to APS Pathogenesis
Presenting Author: Yu Zuo, MD

9:00 am | Hall B5
Session: Pediatric Rheumatology – ePoster I: Basic Science, Biomarkers, & Sclerodermic Fever
Title:  Cutaneous Gene Expression Signatures in Juvenile Myositis Reveal a Prominent IFN Signature in Lesional Skin
Presenting Author: Jessica Turnier

9:00 am | Hall B5
Session: Vasculitis – Non-ANCA-Associated & Related Disorders Poster I: Takayasu's Arteritis & Polymyalgia Rheumatica
Title: Dynamic Distribution and Phenotype Shift from M1 to M2 of Macrophages in Vascular Lesions of Naïve and Treated Patients with Takayasu Arteritis
Presenting Author: Xuifang Kong

9:00 am | B302-B303
ARP Session: Clinical and Translational Research
Title: 3S021 ARP Keynote Address: Paying it Forward: Reciprocal Learning and Sustainable Leadership
Moderator: Susan Murphy, OT, ScD

12:45 pm | A403
Meet the Professor: Clinical Practice: Pain Management
Title: 3S042 MTP: 012 - Fibromyalgia 2019: Update on Management
Speaker: Dan Clauw, MD

1:00 pm | B304/B305
Basic Science: Patient Safety
Title: 3S050 Gout: Pathogenesis and Therapeutic Targets
Moderator: Adam Killian, MD

2:30 pm | B312/B314
Session: 3S084 Systemic Sclerosis & Related Disorder – Clinical I: Therapeutics & Outcomes
Title: Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis— Results of Phase I/II Investigator-Initiated, Double-Blind Randomized Placebo-Controlled Trial
Presenting Author: Dinesh Khanna, MD, MSc

4:30 pm | A404
Meet the Professor: Clinical Practice
Title: 3S121 MTP: 022 - Pulmonary Hypertension in Rheumatic Diseases
Speaker: Dinesh Khanna, MD, MSc

Monday, November 11

7:30 am | B405-B407
ARP Session: Clinical Practice
Title: 4M010 Immunology Boot Camp I: Basis of Targeted Therapy
Moderator: Debra Rizzo, MSN, FNP-BC

8:00 am | B308
Session: 4M004 Genetics & Epigenetics of Scleroderma
Title: Novel Therapies in Development for Scleroderma
Speaker: Dinesh Khanna, MD, MSc

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Basic Science
Title: Effects of Abatacept on T Regulatory Cells in Early Diffuse Systemic Sclerosis
Presenting Author: David A. Fox, MD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Basic Science
Title: Lymphocyte Subset Abnormalities in Early Diffuse Cutaneous Systemic Sclerosis
Presenting Author: David A. Fox, MD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Basic Science
Title: Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma
Presenting Author: Eliza Pei-Suen Tsou, PhD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Basic Science
Title: Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis
Presenting Author: Sirapa Vichaikul

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Clinical II
Title: Multicenter Double-Blind, Proof-of-Concept, Randomized Placebo-Controlled Trial of Riociguat in Systemic Sclerosis-associated Digital Ulcers
Presenting Author: Vivek Nagaraja, MD

9:00 am |Hall B5
Session: Cytokines & Cell Trafficking
Title: Interferon Kappa Promotes the Development of Psoriasis
Presenting Author: Mehrnaz Gharaee-Kermani PhD, MPH, DVM

9:00 am | B213-B214
ACR/ARP Session: Clinical Practice
Title: 4M031 Make Rehab Fun: Virtual Reality & Therapeutic Gaming
Moderator: Susan Murphy, OT, ScD
Speaker: Robert Ferguson, OT

9:00 am | Hall B5
Session: Imaging Of Rheumatic Diseases Poster II
Title: Utility of Coronary Calcium Scoring (CCS) in the Spectrum of Connective Tissue Disorders (CTDs) for the Evaluation of Subclinical Coronary Atherosclerosis – a Systematic Review
Presenting Author: Sohail Farshad, DO (Beaumont)

9:00 am | Hall B5
Session: Vasculitis – ANCA-Associated Poster II
Title: Evaluation of Subclinical Coronary Atherosclerosis in ANCA-associated Small Vessel Vasculitides (AAVs) Compared to Matched Controls Through Visual Assessment of Coronary Arterial Calcium (CAC) Score Using Non-Gated Chest Computed Tomography (CT)
Presenting Author: Sohail Farshad, DO (Beaumont)

11:00 am | B302-B303
ARP Session: Clinical and Translational Research: Pain Management
Title: 4M045 ARP Distinguished Lecturer - A Public Health Approach to Arthritis & Other Rheumatic Conditions: How Growing Attention to Pain Helps
Moderator: Susan Murphy, OT, ScD

1:15 pm | A301
Workshop: Business Administration
Title: 4M081 Workshop: 218 - How to Archive, Share & Access Data for Secondary Analysis
Speaker: Shane Redman, MA

2:30 pm | B405-B407
ARP Session: Clinical Practice
Title: 4M103 Immunology Boot Camp II: Basic Mechanisms of Autoimmunity
Moderator: Debra Rizzo, MSN, FNP-BC

2:30 pm | B306
ARP Session: Clinical and Translational Research
Title: 4M102 ARP-EULAR HP Collaborative Session: Exercise, the "Wonder Drug"
Moderator: Afton Hassett, Psy.D

2:30 am | A302
Session: 4M087 Antiphospholipid Syndrome
Title: Anti-neutrophil Extracellular Trap (NET) Autoantibodies in Primary Antiphospholipid Syndrome
Presenting Author: Yu Zuo, MD

2:45 pm | A302
Session: 4M087 Antiphospholipid Syndrome
Title: Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Presenting Author: Ramadan Ali, PhD

3:45 pm | B309
4M090 Infection-Related Rheumatic Disease
Title: Perioperative Anti-Rheumatic Medications Are Not Associated with 30-day Odds of Infection in Rheumatoid Arthritis Patients Undergoing Surgery: A Retrospective Cohort Study
Presenting Author: Marianne Kerski, MD

4:30 pm | B204
ACR/ARP Session: Clinical and Translational Research
Title: 4M126 Gut Check: Microbiome in SLE, RA & OA
Moderator: Catherine Christen, PharmD

4:45 pm | A311
Session: 4M110 Healthcare Disparities in Rheumatology
Title: Cost-related Prescription Non-adherence Is Associated with Patient-reported Outcomes of Systemic Lupus Erythematosus Activity and Damage: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Presenting Author: Deeba Minhas, MD

Time TBA
Facebook Live Interview - Vision for Lupus Report
Patricia Cagnoli, MD with Lupus Foundation of America and World Lupus Federation

Tuesday, November 12

7:30 am | B405-B407
ARP Session: Clinical Practice
Title: T006 Immunology Boot Camp III: Applying Principles of Immunology to Treatment Decisions
Moderator: Debra Rizzo, MSN, FNP-BC

7:45 am | A314
Title: 5T020 Workshop: 225 - Hands-On Approach to Perform Minor Salivary Gland (Lip) Biopsy
Speakers: Robert Ike, MD and Sara McCoy, MD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Clinical Poster III
Title: Subsets in Systemic Sclerosis-ILD: Working Towards Consensus-Based Definitions
Presenting Author: David Roofeh, MD

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Clinical Poster III
Responsiveness to Change of the Modified Rodnan Skin Score in a Phase I/II Double-Blind Randomized Placebo-Controlled Trial
Presenting Author: Dinesh Khanna, MD, MSc

9:00 am | Hall B5
Session: Systemic Sclerosis & Related Disorders – Clinical Poster III
Title: Forced Vital Capacity Trajectories for Systemic Sclerosis-associated Interstitial Lung Disease - Analysis from the University of Michigan Scleroderma Cohort
Presenting Author: Mirette Habib

9:00 am | B204
ACR/ARP Session: Clinical and Translational Research: Pediatrics
Title: 5T035 Engage Pediatric Patients in Research
Moderator: Carol Dodge, OT, CHT

9:00 am | Hall B5
Session: RA – Treatments Poster III: Safety and Outcomes
Title: Patient Characteristics Associated with Long Term Glucocorticoid Use in a Commercially Insured Incident RA Cohort
Presenting Author: Beth Wallace, MD, MS

9:00 am | Hall B5
Session: SLE – Clinical III: Treatment
Title: Prescription Opioid Use and Osteoporotic Fractures in Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Presenting Author: Emily Somers, PhD, ScM

9:00 am | B308
Session: 5T031 Doctors’ Toolbox: Learning to Communicate and Teach
Title: What Great Attendings Do
Speaker: Nathan Houchens, MD

9:00 am | Hall B5
Session: SLE – Etiology & Pathogenesis II
Title: Interferon Alpha Promotes Caspase-Dependent Apoptosis Independently of Reactive Oxygen Species in Ultraviolet B-Exposed Keratinocytes
Presenting Author: Shannon Estadt, BS

9:00 am | Hall B5
Session: SLE – Etiology & Pathogenesis II
Title: Staphylococcus Aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by Interferon-Mediated Barrier Disruption
Presenting Author: Sirisha Sirobhushanam, PhD

9:00 am | Hall B5
Session: SLE – Etiology & Pathogenesis II
Title: BATF2 Contributes to Interferon Dysregulation in SLE Keratinocytes
Presenting Author: Jessica Turnier

9:00 am | Hall B5
Late Breaking Abstracts: Clinical and Translational Research
Title: NYX-2925 Impacts Functional and Chemical Neuroimaging Biomarkers and Patient-reported Outcomes of Pain in Patients with Fibromyalgia
Presenting Author: Richard Harris

11:30 pm | B218
ARP Session: Clinical Practice: 5T046 Scleroderma Made Simple: What Is It & How Do We Manage It?
Title: Scleroderma: Self Management and Prevention of Contractures
Speaker: Carol Dodge, OT, CHT

2:30 pm | A302
5T087 Edmond L. Dubois, MD Memorial Lecture: SLE – Basic Science
Title: Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus
Speaker: Jason Knight, MD, PhD

2:30 pm | B204
ACR/ARP Session: Clinical Practice: Pain Management
Title: 5T100 No More Counting Sheep: Evidence-Based Sleep Management
Moderator: Afton Hassett, Psy.D

2:30 pm | B204
ACR/ARP Session: Clinical Practice: Pain Management
Title: Sleep and Rheumatic Diseases: The Patient Perspective
Speaker: Anna Katz, PhD

3:30 pm | B204
ACR/ARP Session: Clinical Practice: Pain Management
Title: Sleep & Symptoms of Rheumatic Disease: The Evidence
Speaker: Anna Katz, PhD

4:45 pm | B309
Session: 5T115 SLE – Etiology & Pathogenesis I: Signaling Pathways
Title: The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Presenting Author: Gautam Sule, PhD

5:30 pm | A302
ARP Session: Clinical Practice: 5T120 Mechanisms & Mediators of Psychiatric Comorbidity in Rheumatology
Title: Mental Health Is More Than Psychopathology
Speaker: Afton Hassett, PsyD

5:45 pm | B211-B212
Session: 5T113 Muscle Biology, Myositis & Myopathies II
Title: Pain Patterns in Idiopathic Inflammatory Myopathy (IIM): Associations with Disease Activity Measures (Muscle Enzymes, Manual Muscle Testing 8), Patient-Reported Quality of Life (HAQ) and Pain Scales (Widespread Pain Index (WPI), Symptom Severity Index (SSI) and Visual Analogue Scale)
Presenting Author: Elena Schiopu, MD

Wednesday, November 13

7:45 am | A411-A412
ACR/ARP Session: Clinical Practice: Pain Mangement, Patient Safety: 6W002 Non-Drug Interventions for Hip, Knee & Hand OA: 2019 Guideline Update
Title: Presentation of Case to Illustrate Use of Recommendations for Hand OA
Speaker: Carol Dodge, OT, CHT

9:00 am | B304-B305
Session: 6W012 RA – Etiology & Pathogenesis II
Title: The Role of Bradykinin Receptor B1 and Its New Ligand Soluble CD13 in Rheumatoid Arthritis and Inflammatory Arthritis Mouse Model
Presenting Author: David Fox, MD

10:00 am | A311
Session: 6W013 SLE – Clinical VI:Epidemiology, Diagnosis, & Outcomes
Title: Prevalence of Systemic Lupus Erythematosus in the United States: Preliminary Estimates from a Meta-Analysis of the Centers for Disease Control and Prevention Lupus Registries
Presenting Author: Emily Somers, PhD, ScM

Abstracts

5 | Interferon Kappa Promotes the Development of Psoriasis
Authors: Mehrnaz Gharaee-Kermani, Shannon Estadt, Sonya Wolf-Fortune, Johann Gudjonsson and J. Michelle Kahlenberg

7 | Citrullination of Interleukin 6 Augments Its Pro-inflammatory Capacity and Signaling Potency Through Interleukin-6 Receptor in Rheumatoid Arthritis
Authors: Chenyang Lu, Ray Ohara, Phillip Campbell, Yuxuan Du, Alexander Stinson, Jonatan Hervoso, Ellen Cealey, David Fox and Asif Amin

15 | CYR61/TGF-β Axis Promotes Adventitial Fibrosis of Takayasu Arteritis in the IL-17 Mediated Inflammatory Microenvironment
Authors: Lili Ma, Xiufang Kong, Xiaomeng Cui, Sifan Wu, Yujiao Wang and Lindi Jiang

22 | Beta-2 Glycoprotein I as a DNA- and NET-binding Protein
Authors: Kelsey Gockman, Srilakshmi Yalavarthi, Gautam Sule, Alexandra Morris, Yu Zuo and Jason Knight

73 | Potent Anti-neutrophil Properties of the Natural Compound 6-Gingerol in Models of Lupus and Antiphospholipid Syndrome
Authors: Ramadan Ali, Julia Weiner, Alex Gandhi, Shanea Estes and Jason Knight

78 | Ultraviolet Light Induces Increased T Cell Activation in Lupus-Prone Mice via Type I Interferon-Dependent Inhibition of T Regulatory Cells
Authors: Sonya Wolf-Fortune, Shannon Estadt, Jonathan Theros, Tyson Moore, Jason Ellis, Jianhua Liu, Tamra Reed, Chaim Jacob, Johann Gudjonsson and J Michelle Kahlenberg

109 | Targeting CD6 Expression Attenuates T Cell Activity in Murine Collagen Induced Arthritis
Authors: Yan Li, Jeffrey H. Ruth, Stephanie Rasmussen, Kalana S. Athukorala, Daniel P. Weber, M. Asif Amin, Phillip Campbell, Nora Singer, David Fox and Feng Lin

127 | Elevated Levels of the Neutrophil Extracellular Trap-binding Protein LILRA3 in Primary Antiphospholipid Syndrome
Authors: Hui Shi, Srilakshmi Yalavarthi, Jianping Guo and Jason Knight

128 | Metabolomics Analysis Identifies Biomarkers for APS and Suggests a Potential New Pathway Related to APS Pathogenesis
Authors: Chun Li, Yu Zuo, Jason Knight, Juan Feng, Xian Wang, David Karp and Zhanguo Li

134 | Non-criteria’ Antiphospholipid Antibodies Add Value to Antiphospholipid Syndrome Diagnoses in a Large Chinese Cohort
Authors: Jieyu Gu, Tingting Liu, Liyan Wan, Gary L. Norman, Chengde Yang and Hui Shi

0137 | The Clinical and Laboratory Characteristics of Antiphospholipid Antibody Positive Patients Included in the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ("Registry")
Authors: Ecem Sevim, Diane Zisa, Danieli Andrade, Vittorio Pengo, Savino Sciascia, Maria Tektonidou, Amaia Ugarte, Maria Gerosa, H Michael Belmont, Rosario Lopez Pedrera0, Lanlan Ji1, Paul Fortin2, Maria Efthymiou, Guilherme De Jesus, David Branch, Laura Andreoli, Michelle Petri, Ricard Cervera, Esther Rodriguez, Jason Knight, Tatsuya Atsumi, Rohan Willis, Maria Laura Bertolaccini, Hannah Cohen, Robert Roubey, Doruk Erkan, Medha Barbhaiya and on Behalf of APS ACTION

144 | Antiphospholipid Syndrome-Associated Preeclampsia Is Defined by a Distinct Clinical Phenotype
Authors: Shashank Cheemalavagu, Beth Wallace, Wendy Marder, Jason Knight and Andrew Vreede

185 | Accrual of Multimorbidity After Incident Rheumatoid Arthritis and Matched Comparators Using a Large Prospective Cohort with 30 Years of Follow-up
Authors: Kazuki Yoshida, Tzu-Chieh Lin, Melissa Y Wei, Susan Malspeis, Su H. Chu, Carlos Camargo, Benjamin A. Raby, Hyon K. Choi, Sara K. Tedeschi, Medha Barbhaiya, Bing Lu, Karen Costenbader, Elizabeth Karlson and Jeffrey Sparks

374 | The INBUILD Trial of Nintedanib in Patients with Progressive Fibrosing Interstitial Lung Diseases: Subgroup with Autoimmune Diseases
Authors: Eric Matteson, Clive Kelly, Jörg Distler, Anna Maria Hoffmann-Vold, James Seibold, Shikha Mittoo, Oliver Distler, Rainer-Georg Goeldner, Rozsa Schlenker-Herceg, Susanne Stowasser, Manuel Quaresma and Kevin Flaherty

554 | Evidence to Guide Glucocorticoid Tapering Is Lacking in RA
Authors: Beth Wallace, David Wallace, Akbar Waljee and Daniel Clauw

678 | Performance of the EULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus in Men, Diverse Ethnicities, and Early Disease
Authors: Martin Aringer, Ralph Brinks, Karen Costenbader, David Daikh, Dimitrios Boumpas, David Jayne, Diane Kamen, Marta Mosca, Rosalind Ramsey-Goldman, Josef Smolen, David Wofsy, Betty Diamond, Søren Jacobsen, W Joseph McCune, Guillermo Ruiz-Irastorza, Matthias Schneider, Murray Urowitz, George Bertsias, Bimba Hoyer, Nicolai Leuchten, Chiara Tani, Sara K. Tedeschi, Zahi Touma, Branimir Anic, Florence Assan, Daniel TM Chan, Ann E Clarke, Mary Crow, László Czirják, Andrea Doria, Winfried Graninger, Bernadette Halda-Kiss, Sarfaraz Hasni, Peter Izmirly, Michelle Jung, Gabor Kumanovics, Xavier Mariette, Ivan Padjen, Jose Maria Pego-Reigosa, Juanita Romero-Diaz, Iñigo Rua Figueroa, Raphaèle Seror, Georg Stummvoll, Yoshiya Tanaka, Maria Tektonidou, Carlos Vasconcelos, Edward Vital, Daniel Wallace, Sule Yavuz, Raymond Naden, Thomas Dörner and Sindhu R. Johnson

708 | Improvement and Stabilization of Lung Function in Patients with SSc-ILD Treated with Nintedanib vs Placebo in a Randomized, Placebo-Controlled Phase III Trial: Proportions of Patients with FVC Changes Using Cutoffs Previously Proposed to Define Minimally Clinically Important Differences
Authors: Yannick Allanore, Dinesh Khanna, Elizabeth Volkmann, Christian Stock, Martina Gahlemann, Nils Schoof, Oliver Distler and Toby Maher

710 | Relationship Between High-Resolution Computer Tomography and FVC% Predicted for Classification of Pulmonary Hypertension in Systemic Sclerosis
Authors: Sara Jaafar, Paul Cronin, Dharshan Vummidi, Scott Visovatti, Amber Young, Suiyuan Huang, Vallerie McLaughlin and Dinesh Khanna

737 | The MUC5B Promoter Variant Does Not Predict Outcomes in Systemic Sclerosisrelated Interstitial Lung Disease
Authors: Elizabeth Volkmann, Donald Tashkin, Michael Roth, Ning Li, Grace Kim, Jonathan Goldin, Maureen Mayes, Julio Charles, Philip Clements, Daniel Furst, Dinesh Khanna, Robert Elashoff and Shervin Assassi

754 | Dynamic Distribution and Phenotype Shift from M1 to M2 of Macrophages in Vascular Lesions of Naïve and Treated Patients with Takayasu Arteritis
Authors: Xiufang Kong, Ming Xu, Xiaomeng Cui, Lingying Ma, Huiyong Chen, Lili Ma and Lindi Jiang 

763 | Treatment Efficacy Evaluation of Leflunomide by Regulating Macrophages in Takayasu Arteritis
Authors: Xiaomeng Cui, Xiaomin Dai, Xiufang Kong, Rongyi Chen, Lili Ma, Ying Sun and Lindi Jiang

775 | Cutaneous Gene Expression Signatures in Juvenile Myositis Reveal a Prominent IFN Signature in Lesional Skin
Authors: Jessica Afton, Celine Berthier, Lam Tsoi, Lori Lowe, Gabrielle Morgan, Johann Gudjonsson, Lauren Pachman and J. Michelle Kahlenberg

801 | Preliminary Analysis of Hearing Loss in a Neonatal-Onset Multisystem Inflammatory Disease (NOMID) Cohort Followed over a Mean of 10 Years: Normal Hearing at Baseline and Early Treatment with Anakinra Area Associated with Maintenance of Normal Hearing
Authors: Sara Alehashemi, Megha Garg, Kelly King, Chris Zalewski, Adriana de Jesus, John Butman, Jonah Eisenberg, Carmen Brewer, Jeffrey Kim and Raphaela Goldbach-Mansky

863 | Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis— Results of Phase I/II Investigator-Initiated, Double-Blind Randomized Placebo-Controlled Trial
Authors: Dinesh Khanna, Erica Bush, Vivek Nagaraja, Andrew Koenig, Puja Khanna, Amber Young, Jeffrey Moore, David Fox and Robert Lafyatis

867 | Safety and Efficacy of B-cell Depletion with Rituximab for the Treatment of Systemic Sclerosis-associated Pulmonary Arterial Hypertension in a Multi-center NIH Clinical Trial
Authors: Mark Nicolls, David Badesch, Lorinda Chung, Robyn Domsic, Thomas Medsger, Ashley Pinckney, Lynette Keyes-Elstein, Carla D'Aveta, Meagan Spychala, R James White, Paul Hassoun, Fernando Torres, Jerry Molitor0, Dinesh Khanna1, Holden Maeker, Beverly Welch,
Ellen Goldmuntz, Roham Zamanian and -- On Behalf of ASC01 Investigators

882 | Serum Anti-Vimentin Autoantibodies May Uniquely Predict Response to Therapy in Lupus Nephritis
Authors: Andrew Kinloch, Matthew Cascino, Jian Dai, Rene Bermea, Kichul Ko, Margaret Vesselits, Maureen Legendre, Michael Okoreeh, David Markovitz, Leonard Dragone, Michael Townsend and Marcus Clark

959 | A Novel Image Analysis Program, “CytoSkaler”, Demonstrates That Anti-Vimentin Antibody Affinity Maturation in Lupus Tubulointerstitial Nephritis Also Results in More Selective Antigen Targeting
Authors: Andrew Kinloch, Aazam Mohsin, Yuta Asano, Carole Henry, Nirit Mor Vaknin, Maureen Legendre, Patrick Wilson, David Markovitz and Marcus Clark

1018 | Renal Single Cell Genomics Links Type II Interferon and Lupus Nephritis in African-Americans
Authors: Andrea Fava, Yuji Zhang, Jill Buyon, Chaim Putterman, Nir Hacohen, Arnon Arazi, Celine Berthier, Deepak Rao, Michael Brenner, David Wofsy, Anne Davidson, Mathias Kretzler, David Hildeman, E. Steve Woodle, Betty Diamond, Thomas Tuschl, Evan Der, Hemant Suryawanshi, H. Michael Belmont, Peter Izmirly, Robert Clancy, The Accelerating Medicines Partnership and Michelle Petri

1048 | Clonally Expanded CD4+ Cytotoxic T Cells, Endothelial Cell Apoptosis and the Pathogenesis of Early Systemic Sclerosis
Authors: Takashi Maehara, Cory Perugino, Naoki Kaneko, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay Mahajan, Hang Liu, Samuel Murphy, Musie Ghebremichael, Yesim Tuncay, Emanuel Della Torre, Lloyd Liang, Sydney Montesi, Zachary Wallace, David Fox, Robert Lafyatis, John Stone, Dinesh Khanna and Shiv Pillai

1057 | Dissecting the Cellular Mechanism of Prostacyclin Analog Iloprost in Reversing Vascular Dysfunction in Scleroderma
Authors: Pei-Suen Tsou, Nicholas Flavahan and Dinesh Khanna

1058 | Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis
Authors: Sirapa Vichaikul, Phillip Campbell, M. Asif Amin, Jeffrey H. Ruth, Dallas Rohraff, David Fox, Dinesh Khanna, Amr Sawalha and Pei-Suen Tsou

1062 | Lymphocyte Subset Abnormalities in Early Diffuse Cutaneous Systemic Sclerosis
Authors: David Fox, Steven Lundy, Michael Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Evan Wiewiora, Cathie Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna

1063 | Effects of Abatacept on T Regulatory Cells in Early Diffuse Systemic Sclerosis
Authors: David Fox, Michael Whitfield, Veronica Berrocal, Steven K. Lundy, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Evan Wiewiora, Cathie Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna

1071 | A Common Transcriptional Signature Is Present in Circulating Classical Monocytes and Skin Macrophages in Systemic Sclerosis
Authors: Hadijat Makinde, Salina Dominguez, Gaurav Gadhvi, Kathleen Aren, Chang Zeng, Garrett Eickelberg, Dinesh Khanna, Shervin Assassi, Tracy Frech, Monique Hinchcliff, Carla Cuda, Deborah Winter and Harris Perlman

1165 | Utility of Coronary Calcium Scoring (CCS) in the Spectrum of Connective Tissue Disorders (CTDs) for the Evaluation of Subclinical Coronary Atherosclerosis – a Systematic Review
Authors: Sohail Farshad, Alexandra Halalau, Whitney Townsend and Elena Schiopu

1240 | A Randomized, Phase 2 Study Evaluating the Efficacy and Safety of Anakinra in Difficult-To-Treat Acute Gouty Arthritis: The anaGO Study
Authors: Kenneth Saag, Alexander So, Puja Khanna, Robert Keenan, Sven Ohlman, Torbjörn Kullenberg, Lisa Osterling Koskinen, Michael Pillinger and Robert Terkeltaub

1308 | Subject Enrichment Criteria for Phase 3 Studies of Lorecivivint (SM04690), a Potential Disease-Modifying Knee Osteoarthritis Drug: A Post Hoc Study on the Effects of Baseline Comorbid Pain and Joint Space Width on Patient-Reported Outcomes
Authors: Sarah Kennedy, Chris Swearingen, Jeyanesh Tambiah, Daniel Clauw and Philip G Conaghan

1628 | Lung Function Decline in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease in the SENSCIS Trial: Subgroup Analysis by Time Since First Non-Raynaud Symptom
Authors: Aryeh Fischer, Oliver Distler, Dinesh Khanna, Yannick Allanore, Anna Maria Hoffmann-Vold, Gabriele Valentini, Toby Maher, Martin Aringer, Leslie Meng, Margarida Alves, Martina Gahlemann, Manuel Quaresma and Masataka Kuwana

1644 | Effects of Nintedanib in Patients with Diffuse and Limited Cutaneous Systemic Sclerosis and Interstitial Lung Disease: Subgroup Analysis of the SENSCIS Trial
Authors: Masataka Kuwana, Kristin Highland, Martina Gahlemann, Christopher Denton, Aryeh Fischer, Maureen Mayes, Virginia Steen, Dinesh Khanna, Yannick Allanore, Mannaig Girard, Margarida Alves, Susanne Stowasser and Oliver Distler

1647 | The Collaborative National Quality and Efficacy Registry for Scleroderma: Data Completion Outcomes from a Multicenter United States Cohort Using Guideline-Based Registry Practices
Authors: Victoria Shanmugam, Tracy Frech, Virginia Steen, Laura Hummers, Ami Shah, Elana Bernstein, Dinesh Khanna, Jessica Gordon, Flavia Castelino, Lorinda Chung, Faye Hant, Emily Startup, John VanBuren, Luke Evnin and Shervin Assassi

1649 | Mycophenolate Mofetil and Cyclophosphamide Improve Health-Related Quality of Life in Patients with Systemic Sclerosis Who Participated in SLS II
Authors: Elizabeth Volkmann, Donald Tashkin, Michael Roth, Holly LeClair, Philip Clements, Daniel Furst, Robert Elashoff, Dinesh Khanna

1651 | Multicenter Double-Blind, Proof-of-Concept, Randomized Placebo-Controlled Trial of Riociguat in Systemic Sclerosis-associated Digital Ulcers
Authors: Vivek Nagaraja, Cathie Spino, Pei-Suen Tsou, Robyn Domsic, Robert Lafyatis, Tracy Frech, Jessica Gordon, Virginia Steen and Dinesh Khanna

1653 | Efficacy and Safety of Romilkimab in Diffuse Cutaneous Systemic Sclerosis (dcSSc):A Randomized, Double-Blind, Placebo-Controlled, 24-week, Proof of Concept Study
Authors: Yannick Allanore, Christopher Denton, Dinesh Khanna, Christina Soubrane, Corinne Esperet, Frederic Marrache, Raphael Bejuit, Amel Lahmar and Peter Wung

1670 | Evaluation of Subclinical Coronary Atherosclerosis in ANCA-associated Small Vessel Vasculitides (AAVs) Compared to Matched Controls Through Visual Assessment of Coronary Arterial Calcium (CAC) Score Using Non-Gated Chest Computed Tomography (CT)
Authors: Sohail Farshad, Alexandra Halalau, Sayf Al-Katib, Julie George and Elena Schiopu

1707 | IL-6 Promotes IgG4-related Disease by Inducing Fibroblast-dependent Tfh Cell and B Cell Differentiation Factors
Authors: Zongfei Ji, Rongyi Chen, Xiaomeng Cui, Lili Ma, Xiufang Kong, Lingying Ma, Ying Sun, Xiaomin Dai, Zhuojun Zhang, Huiyong Chen and Lindi Jiang

1764 | CCL25, a Novel Fibroblast and Macrophage Chemoattractant That Potentiates RA Bone Erosion
Authors: Sadiq Umar, Katrien Raemdonck, Karol Palasiewicz, Michael Volin, Shiva Arami, Suncica Volkov, Nadera Sweiss, Asif Amin and Shiva Shahrara

1783 | Reversible Dysregulation of Renal Circadian Rhythm in Lupus Nephritis
Authors: Rakesh Mishra, Ramalingam Bethunaickan, Celine Berthier, Zhengzi Yi, Joshua Strohl, Patricio Huerta, Weijia Zhang and Anne Davidson

1784 | Single Cell Analysis of Renal Myeloid Cells from NZB/WF1 Mice with Lupus Nephritis Reveals Multiple Subsets with Altered Functions
Authors: Rakesh Mishra, Celine Berthier, Heather Geiger, Weijia Zhang and Anne Davidson

1788 | Anti-neutrophil Extracellular Trap (NET) Autoantibodies in Primary Antiphospholipid Syndrome
Authors: Yu Zuo, Srilakshmi Yalavarthi, Kelsey Gockman, David Karp, Quan-Zhen Li and Jason Knight

1789 | Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Authors: Ramadan Ali, Hui Shi, Srilakshmi Yalavarthi and Jason Knight

1791 | Antiphospholipid Antibody Profile Stability over Time: Prospective Results from AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ("Registry")
Authors: Elena Gkrouzman, Ecem Sevim, Jackie Finik, Danieli Andrade, Vittorio Pengo, Savino Sciascia, Maria Tektonidou, Amaia Ugarte, Cecilia Chighizola, H Michael Belmont, Laura Pérez Sánchez, Lanlan Ji, Paul Fortin, Maria Efthymiou, Guilherme De Jesus, David Branch, Cecilia Nalli, Michelle Petri, Ricard Cervera, Esther Rodriguez, Jason Knight, Tatsuya Atsumi, Rohan Willis, Maria Laura Bertolaccini, Hannah Cohen, Jacob Rand, Doruk Erkan and On Behalf Of APS ACTION

1793 | Descriptive Analysis of Biopsy-proven Antiphospholipid Antibody-associated Nephropathy Patients Included in the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository (“Registry”)
Authors: Maxime Taghavi, Medha Barbhaiya, Maria Tektonidou, Paul Fortin, Danieli Andrade, Jason Knight, Bahar Artim-Esen, Tatsuya Atsumi, Hannah Cohen, Lanlan Ji, Savino Sciascia, Surya Seshan, Doruk Erkan3 and on Behalf of APS ACTION

1805 | Perioperative Anti-Rheumatic Medications Are Not Associated with 30-day Odds of Infection in Rheumatoid Arthritis Patients Undergoing Surgery: A Retrospective Cohort Study
Authors: Marianne Kerski, Peter Boersma, Eric Miller, Ashley Brenner, Genevieve Melton and Anna Shmagel

1807 | Teprotumumab, a Novel Biologic for Active Thyroid Eye Disease
Authors: George J. Kahaly, Saba Sile, Elizabeth H.Z. Thompson, Thomas Vescio, Renee Perdok, Jeffrey W. Sherman, Terry J. Smith and Raymond S. Douglas

1830 | Short- and Long-term Morbidity and Mortality Outcomes of African American Patients with Systemic Sclerosis-Related Interstitial Lung Disease
Authors: Elizabeth Volkmann, Virginia Steen, Ning Li, Michael Roth, Philip Clements, Dinesh Khanna, Daniel Furst, Shervin Assassi, Grace Kim, Jonathan Goldin, Robert Elashoff and Donald Tashkin

1833 | Efficacy and Safety of Nintedanib in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease by Use of Mycophenolate at Baseline: Subgroup Analysis of the SENSCIS Trial
Authors: Kristin Highland, Oliver Distler, Masataka Kuwana, Yannick Allanore, Shervin Assassi, Arata Azuma, Arnaud Bourdin, Christopher Denton, Jörg Distler, Anna Maria Hoffmann-Vold, Dinesh Khanna, Maureen Mayes, Ganesh Raghu, Madelon Vonk, Martina Gahlemann, Mannaig Girard, Susanne Stowasser, Donald Zoz, Aryeh Fischer and Toby Mahe

1834 | Serum Interferon Chemokine Score Predicts Better Response to Immunosuppression in Systemic Sclerosis Related Interstitial Lung Disease
Authors: Shervin Assassi, Ning Li, Elizabeth Volkmann, Maureen Mayes, Jun Ying, Michael Roth, Philip Clements, Daniel Furst, Dinesh Khanna, Jonathan Goldin, Robert Elashoff and Donald Tashkin

1849 | Cost-related Prescription Non-adherence Is Associated with Patient-reported Outcomes of Systemic Lupus Erythematosus Activity and Damage: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Deeba Minhas, Wendy Marder, Sioban Harlow, Hanna Saltzman, Afton Hassett, Suzanna Zick, Lu Wang, Kamil Barbour, Charles Helmick, Caroline Gordon, W. Joseph McCune and Emily Somers

1881 | Association of Pain Centralization with DMARD Response in Active RA
Authors: Andrew Heisler, Jing Song, Dorothy Dunlop, Alyssa Wohlfahrt, Marcy Bolster, Wendy Marder, Clifton Bingham, Daniel Clauw, Tuhina Neogi and Yvonne Lee

1882 | Anti-CCP Antibody and Pain Sensitization in Rheumatoid Arthritis
Authors: Yoon Mun, Tuhina Neogi, Jing Song, Dorothy Dunlop, Andrew Heisler, Marcy Bolster, Clifton Bingham, Wendy Marder, Alyssa Wohlfahrt and Yvonne Lee

1957 | Aggregation of Functional Variants in NOTCH4 Gene Increases SSc Risk
Authors: Pravitt Gourh, Sarah Safran, Theresa Alexander, Steven Boyden, Ami Shah, Maureen Mayes, Ayo Doumatey, Amy Bentley, Daniel Shriner, Robyn Domsic, Thomas Medsger Jr, Paula Ramos, Richard Silver, Virginia Steen, John Varga, Vivien Hsu, Lesley Saketkoo, Elena Schiopu, Dinesh Khanna, Jessica Gordon, Brynn Kron, Lindsey Criswell, Heather Gladue, Chris Derk, Elana Bernstein, S Louis Bridges, Victoria Shanmugam, Kathleen Kolstad, Lorinda Chung, Suzanne Kafaja, Reem Jan, Marcin Trojanowski, Avram Goldberg, Benjamin Korman, Peter Steinbach, Settara Chandrasekharappa, James Mullikin, Adebowale Adeyemo, Charles Rotimi, Frederick Wigley, Daniel Kastner, Francesco Boin and Elaine Remmers

2030 | Staphylococcus Aureus Colonization Is Increased on Lupus Skin Lesions and Is Promoted by Interferon-Mediated Barrier Disruption
Authors: Sirisha Sirobhushanam, Navya Parsa, Tamra Reed, Celine Berthier, Mrinal Sarkar, Grace Hile, Lam Tsoi, Alexander Horswill, Johann Gudjonsson and J Michelle Kahlenberg

2031 | Interferon Alpha Promotes Caspase-Dependent Apoptosis Independently of Reactive Oxygen Species in Ultraviolet B-Exposed Keratinocytes
Authors: Shannon Estadt and J. Michelle Kahlenberg

2040 | BATF2 Contributes to Interferon Dysregulation in SLE Keratinocytes
Authors: Jessica Turnier Celine Berthier, Lam Tsoi, Danielle Barnes, Grace Hile, Tamra Reed, Jianhua Liu, Johann Gudjonsson and J. Michelle Kahlenberg

2106 |Features of Pneumocystis Jirovecii Pneumonia in Juvenile Idiopathic Inflammatory Myopathy
Authors: Sara Sabbagh, Jessica Neely, Jamie Lai, Anjali Sura, Kelly Rouster-Stevens, Svetlana Lvovich, Tara McGrath, Lori Tucker, Heinrike Schmeling, Jordan Roberts, Lisa G. Rider and Susan Kim

2267 | The Association Between Non-restorative Sleep and Diurnal Patterns of Cognitive Function and Fatigue in People with Fibromyalgia and Matched Controls
Authors: Daniel Whibley, David Williams, Daniel Clauw and Anna Kratz

2388 | Patient Characteristics Associated with Long Term Glucocorticoid Use in a Commercially Insured Incident RA Cohort
Authors: Beth Wallace, Yuqing Gao, Paul Lin, Neil Kamdar, Jeffrey Curtis, Kenneth Saag, Daniel Clauw and Akbar Waljee

2553 | Prescription Opioid Use and Osteoporotic Fractures in Systemic Lupus Erythematosus: The Michigan Lupus Epidemiology & Surveillance (MILES) Cohort
Authors: Emily Somers, Sioban Harlow, Nina Zhou, Lu Wang, Kamil Barbour, Charles Helmick, Caroline Gordon, Deeba Minhas, Beth Wallace, Afton Hassett, Suzanna Zick, W. Joseph McCune and Wendy Marder

2608 | Subsets in Systemic Sclerosis-ILD: Working Towards Consensus-Based Definitions
Authors: David Roofeh, Kevin Brown, Donald Tashkin, Shervin Assassi, Shaney Barratt, Elana Bernstein, Nitin Bhatt, Lorinda Chung, Harold Collard, Richard Conway, Paul Dellaripa, Christopher Denton, Oliver Distler, Robyn Domsic, Tracy J. Doyle, Puneet Garcha, Nishant Gupta, Anna Maria Hoffmann-Vold, Vivien Hsu, Francesca Ingegnoli, Kerri Johannson, Bashar Kahaleh, Leticia Kawano-Dourado, Ella Kazerooni, Surabhi Khanna, Peter Korsten, Celia JF Lin, Toby Maher, Stephen Mathai, Fernando Martinez, Eric Matteson, Vivek Nagaraja, Chester Oddis, Juan Ovalles-Bonilla, John Pauling, Ganesh Raghu, Ignasi Rodriguez-Pinto, Ivan Rosas, James Seibold, Virginia Steen, Vibeke Strand, Elizabeth Volkmann, Dharshan Vummidi, Simon Walsh, Donald Zoz, Athol Wells and Dinesh Khanna

2616 | Forced Vital Capacity Trajectories for Systemic Sclerosis-associated Interstitial Lung Disease - Analysis from the University of Michigan Scleroderma Cohort
Authors: Mirette Habib, Sara Jaafar, Annie Park, Suiyuan Huang, Wen Ye, Vivek Nagaraja, Eric White, Kevin Flaherty and Dinesh Khanna

2617 | Responsiveness to Change of the Modified Rodnan Skin Score in a Phase I/II Double-Blind Randomized Placebo-Controlled Trial
Authors: Erica Bush, Vivek Nagaraja, Robert Lafyatis and Dinesh Khanna

2626 | Cell-free Mitochondrial DNA Levels in Granulomatosis with Polyangiitis
Authors: Lindsay Lally, Sebastian E. Sattui, Jackie Finik, Augustine Choi, Rennie Rhee, Peter Merkel, W. Joseph McCune, E William St. Clair, Ulrich Specks, John Stone and Robert Spiera

2717 | Long-term Outcome of Juvenile-onset Psoriatic Arthritis
Authors: Devy Zisman, Tal Gazitt, Amir Haddad, Idit Lavi, Snezana Barac, Vinod Chandran, Jan Dutz, Lihi Eder, James T Elder, Richard Hayday, Proton Rahman, Christopher Ritchlin, Sherry Rohekar, Cheryl F. Rosen and Dafna Gladman

2733 | Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus
Authors: Gautam Sule, Kristen Gilley, Andrew Fernandes, Srilakshmi Yalavarthi and Jason Knight

2740 | Takayasu Arteritis Associated Risk Locus in IL6 Represses the Anti-inflammatory Gene GPNMB Through Chromatin Looping and Recruiting MEF2-HDAC Complex
Authors: Xiufang Kong and Amr Sawalha

2811 | The IRE1α Pathway Mediates Neutrophil Stress and NETosis in Lupus
Authors: Gautam Sule, Basel Abuaita, Paul Steffes, Kristen Gilley, Andrew Fernandes, Mary O’Riordan and Jason Knight

2841 | A Double-Blind, Placebo-Controlled, Phase 2 Trial of a Novel Toll-Like Receptor 7/8/9 Antagonist (IMO-8400) in Dermatomyositis
Authors: Yoo Jung Kim, Elena Schiopu, Katalin Dankó, Tahseen Mozaffar, Srinivas Chunduru, Kirstin Lees, Namita Goyal, David Fiorentino and Kavita Sarin

2845 | Pain Patterns in Idiopathic Inflammatory Myopathy (IIM): Associations with Disease Activity Measures (Muscle Enzymes, Manual Muscle Testing 8), Patient-Reported Quality of Life (HAQ) and Pain Scales (Widespread Pain Index (WPI), Symptom Severity Index (SSI) and Visual Analogue Scale)
Authors: Elena Schiopu, Sohail Farshad, Nada Abdulaziz, Stacey Anderson and Ann Impens

2858 | The Role of Bradykinin Receptor B1 and Its New Ligand Soluble CD13 in Rheumatoid Arthritis and Inflammatory Arthritis Mouse Model
Authors: Chenyang Lu, Phillip Campbell, Jonatan Hervoso, Stephanie Rasmussen, Wenyi Fu, Jeffrey Ruth, David Fox and Asif Amin

2886 | Prevalence of Systemic Lupus Erythematosus in the United States: Preliminary Estimates from a Meta-Analysis of the Centers for Disease Control and Prevention Lupus Registries
Authors: Emily Somers, Lu Wang, W Joseph McCune, S Sam Lim, Cristina Drenkard, Elizabeth Ferucci, Maria Dall'Era, Caroline Gordon, Charles Helmick, Hilary Parton and Peter Izmirly

2915 | Machine-learning Classification Identifies a Subset of Patients That Improve on Abatacept via Modulation of a CD28-Related Pathway 
Authors: Bhaven Mehta, Jennifer Franks, Yiwei Yuan, Yue Wang, Veronica Berrocal, Tammara Wood, Cathie Spino, David Fox, Dinesh Khanna and Michael Whitfield

2916 | Ancestry-Specific Classical HLA Alleles Define Phenotypic Subsets in the African American Scleroderma Population
Authors: Pravitt Gourh, Sarah Safran, Steven Boyden, Ami Shah, Maureen Mayes, Ayo Doumatey, Amy Bentley, Daniel Shriner, Robyn Domsic, Thomas Medsger Jr, Paula Ramos, Richard Silver, Virginia Steen, John Varga, Vivien Hsu, Lesley Saketkoo, Elena Schiopu, Dinesh Khanna, Jessica Gordon, Brynn Kron, Lindsey Criswell, Heather Gladue, Chris Derk, Elana Bernstein, S Louis Bridges, Victoria Shanmugam, Kathleen Kolstad, Lorinda Chung, Suzanne Kafaja, Reem Jan, Marcin Trojanowski, Avram Goldberg, Benjamin Korman, Peter Steinbach, Settara Chandrasekharappa, James Mullikin, Adebowale Adeyemo, Charles Rotimi, Frederick Wigley, Daniel Kastner, Francesco Boin, Elaine Remmers and Theresa Alexander

L03 NYX-2925 | Impacts Functional and Chemical Neuroimaging Biomarkers and Patientreported Outcomes of Pain in Patients with Fibromyalgia
Authors: Steven Harte, Leslie Arnold, Eric Ichesco, Christopher Crumb, Mary Suh, Laurel Sindelar, Chelsea Kaplan, Tony Larkin, Andrew Schrepf, Daniel Clauw, Stephen Sainati and Richard Harris